Results 161 to 170 of about 2,977,347 (217)
Some of the next articles are maybe not open access.
Small numbers in mutagenicity tests
Archives of Toxicology, 1977Experimental control material for statistical analysis of the results of the micronuclei test in the mouse (NMRI strain) and the Chinese hamster and for the host-mediated assay in the mouse (NMRI strain) using auxotrophic bacterial strains are presented. The binomial distribution of the micronuclei makes it possible to analyse the sample size according
A, Grafe, J, Vollmar
openaire +2 more sources
Mutagenicity testing with Drosophila
Archives of Toxicology, 1980The fruit fly, Drosophila melanogaster with its well known genetics is used to detect newly induced mutations in germ cells. Assay systems are available to determine point mutations, chromosome aberrations and nondisjunction. The sex-linked recessive lethal test is of primary practical importance, because it can detect mutagens with and without ...
openaire +2 more sources
A test for mutagenicity of caffeine in mice
Zeitschrift für Vererbungslehre, 19621. The results are given of an experiment comparing the specific locus mutation-rates in male and in female mice having 0.1% caffeine dissolved in their drinking-water up to the age of ten weeks. Their parents had the same treatment from the time of mating, so that the tested germ-cells might be exposed to caffeine during embryonic development.
Lyon, M F, Phillips, R J, Searle, A G
openaire +2 more sources
Assessment of Mutagenicity Tests
1980Using the short term tests it is possible to evaluate whether or not chemicals are potential mutagens. The mutagenic hazards for man, however, have to be established by tests on mammals in vivo. Where reproducible mutagenicity findings exist with conclusive tests, consideration of the possible threshold doses, together with benefit/risk equations ...
openaire +2 more sources
Journal of Toxicology and Environmental Health, 1980
The universality of the genetic system in living organisms and the high experimental correlation between mutagenicity and carcinogenicity provide the rational basis for the use of mutagenicity in screening of possible carcinogens. The present genetic methodologies using microorganisms, cell cultures, Drosophila, and rodents are evaluated.
C, Ramel, U, Rannug
openaire +2 more sources
The universality of the genetic system in living organisms and the high experimental correlation between mutagenicity and carcinogenicity provide the rational basis for the use of mutagenicity in screening of possible carcinogens. The present genetic methodologies using microorganisms, cell cultures, Drosophila, and rodents are evaluated.
C, Ramel, U, Rannug
openaire +2 more sources
Mutagenicity tests with cadmium in the mouse
Toxicology, 1975The testicle is known to be the critical organ in acute exposure of experimental mammals to cadmium. Such treatment results in temporary sterility and, very often, in the appearance of testicular interstitial cell tumors. The present experiments were performed to determine whether such deleterious effects on the male reproductive organs involved any ...
Gilliavod, N, Leonard, A
openaire +2 more sources
1985
The wx locus assay in maize pollen grains may be conducted using one of two chronic treatment regimens and under in situ conditions. Solutions of a test chemical can be applied to the soil of plants grown in pots or to the nutrient medium of plants grown under hydroponic culture. Under in situ conditions, test plots may be constructed in the field, and
openaire +2 more sources
The wx locus assay in maize pollen grains may be conducted using one of two chronic treatment regimens and under in situ conditions. Solutions of a test chemical can be applied to the soil of plants grown in pots or to the nutrient medium of plants grown under hydroponic culture. Under in situ conditions, test plots may be constructed in the field, and
openaire +2 more sources
Mutagenicity Testing with Drosophila Melanogaster
1985The fruit fly, Drosophila melanogaster, is the eukaryote most often used to detect mutations in germ cells. There are several facts which make this insect an attractive test system for screening chemical compounds for mutagenic activity. The short generation time of only 10 days, low cost of culture media, easy breeding of large numbers of animals with
F E, Würgler, U, Graf
openaire +2 more sources
Microorganisms as test systems for mutagenicity
Archiv f�r Toxikologie, 1971The mutagenic activity of different compounds in bacterial mutagenicity test systems has been investigated. The systems used include back-mutations to prototrophy in auxotrophic strains of Serratia marcescens and forward mutations to galactose prototrophy in a phenotypic galactose negative strain of Escherichia coli.
openaire +2 more sources
Mutagenicity testing with eukaryotic microorganisms
Archives of Toxicology, 1980The different genetic end-points which can be tested to detect genotoxicity of chemicals in fungi and especially in the yeast Saccharomyces cerevisiae are described. They include reversion and forward mutation, mitochondrial deletions and point mutations, mitotic or meiotic intra- and intergenic recombination, chromosomal non-disjunction and aneuploidy.
openaire +2 more sources