Results 161 to 170 of about 11,554 (309)

Expanding the substrate scope of a bacterial monoterpene synthase for the production of sesquiterpenoid and diterpenoid products

The FEBS Journal, EarlyView.
We have converted the only known true bacterial monoterpene synthase, cineole synthase from Streptomyces clavuligerus (bCinS, C10 substrate), to a highly competent sesquiterpene synthase (C15) with a minimum number of rational mutations. By comparison with diterpene synthases (C20), we were then able to bestow diterpene synthase activity on bCinS. This
Nicole G. H. Leferink, Joshua N. Whitehead, Linus O. Johannissen, Nigel S. Scrutton   +3 more
wiley   +1 more source

<i>N</i>,<i>N'</i>,<i>N''</i>-Tris(β-hydroxyethyl)hexahydro-1,3,5-triazine: MAK Value Documentation, addendum - Translation of the German version from 2023. [PDF]

MAK Collect Occup Health Saf
Hartwig A, MAK Commission https://www.dfg.de/de/ueber-uns/gremien/senat/arbeitsstoffe/mitglieder.   +1 more
europepmc   +1 more source

A novel approach to target skin photodamage: Topical application of salt inducible kinase inhibitors

International Journal of Cosmetic Science, EarlyView.
UV‐induced photodamage leads to increased DNA damage and elevated MMP levels, which degrade collagen and contribute to wrinkle formation. SLT‐001 and SLT‐008, novel cosmetic ingredients that target salt‐inducible kinase, help reverse this effect by enhancing DNA repair, reducing MMP expression and decreasing erythema, thereby mitigating photodamage ...
Inbal Rachmin, Béatrice Le Varlet, Claire Regazzetti, Thierry Passeron, Jinhua Wang, David E. Fisher, Philippe Schaison, Braham Shroot   +7 more
wiley   +1 more source

Biosafety and Protective Effects of Tyrosol from Olea europaea L. in Gingivitis: In Vitro and in Vivo Studies

Pesquisa Brasileira em Odontopediatria e Clínica Integrada
Objective: To evaluate tyrosol's biosafety in cytotoxicity, genotoxicity, mutagenicity, and acute toxicity studies in an experimental gingivitis model. Material and Methods: Tyrosol was extracted from a freeze-dried and ultra-processed extract of olive ...
Adriano Costa Ramos, Maria Cecília Freire de Melo, Amanda Ketelly Melo de Lima, Talita Giselly Souza, Andressa Kelly Alves Ferreira, Thuanny Silva de Macêdo, Arnaldo de França Caldas Júnior, Adriana Maria da Silva Telles, Gustavo Pina Godoy   +8 more
doaj  

A perspective review on factors that influence mutagenicity in medicinal plants and their health implications. [PDF]

Toxicol Sci
Fasiku V, Kyagaba D, Hlalele A, Adegoke A, Erukainure OL, Sekhoacha M.   +5 more
europepmc   +1 more source

New alternatives in photoprotection: Preparation and evaluation of lamellar silicate derivatives and their use as sunscreens

International Journal of Cosmetic Science, EarlyView.
The use of nanotechnology in sunscreens has increased, with various filters and organoclays tested for new intercalated formulations. As animal toxicity tests decrease, New Approach Methodologies are favoured. The S4 + OMC‐NC improved cell survival under SSL and showed antimutagenic properties, making it a promising candidate for safe photoprotection ...
Daniel Mabundu Kibwila, Alice Simon, Letícia Coli Louvisse de Abreu, Carlos Rangel Rodrigues, Valeria Pereira de Sousa, Marcelo de Pádula, Lucio Mendes Cabral   +6 more
wiley   +1 more source

Bacillus subtilis RNase HII Is Inefficient at Processing Guanosine Monophosphate and Damaged Ribonucleotides

Molecular Microbiology, EarlyView.
Bacillus subtilis RNase HII corrects ribonucleotide errors and mismatched ribonucleotides, but not damaged ribonucleotides. Mismatched ribonucleotides would also serve as substrates for mismatch repair while damaged ribonucleotides would be addressed through base excision repair.
Julianna R. Cresti, Lyle A. Simmons
wiley   +1 more source

Error-corrected next-generation sequencing mutagenicity assays in human HepaRG cells as human-relevant genetic toxicology new approach methodology. [PDF]

Front Toxicol
Barutcu AR, Bhattarai N, Samuel R, Scaglione J, Recio L.   +4 more
europepmc   +1 more source

Estimation of Mutagenicity Caused by Environmental Pollutants Using Chemical Analysis and Ames Test (Proceedings of the 22nd Symposium on Toxicology and Environmental Health)

, 1997
Noriko Terai, Kazuichi Hayakawa
openalex   +2 more sources

Bacterial Involvement in Oral Squamous Cell Carcinoma and Potentially Malignant Oral Disorders

Oral Diseases, EarlyView.
ABSTRACT Objective To clarify the relationship between oral squamous cell carcinoma (OSCC), potentially malignant oral disease (OPMD), and bacterial flora using metagenomic analysis. Methods This cross‐sectional observational study included 50 patients in the control group and 77 patients with OPMDs, 41 with early OSCCs, and 20 with advanced OSCCs ...
Atsumu Koketsu, Satoshi Fukase, Toru Tamahara, Tatsuru Saito, Akiko Ito, Yutaro Higashi, Tomonari Kajita, Tsuyoshi Kurobane, Masaaki Miyakoshi, Masahiro Iikubo, Kazuki Kumada, Bin Li, Muneaki Shimada, Ritsuko Shimizu, Tetsu Takahashi, Kensuke Yamauchi, Tsuyoshi Sugiura   +16 more
wiley   +1 more source