Results 61 to 70 of about 49,008 (223)

Identification of Hot and Cold Regions for Mutagenesis in the Escherichia coli tdk Gene: A Catalog of Mutational Sites

Environmental and Molecular Mutagenesis, EarlyView.
ABSTRACT We constructed a catalog of mutational sites in the tdk gene of Escherichia coli that consists of 378 different base pair substitutions at 245 different sites (base pairs). This allows us to examine the tendency of different sub‐regions of the gene to be more or less prone to mutations when compared with other sub‐regions.
Katherine Douglas, Dana Sorensen, Arnav Saud, Ananya Sridharan, Mallika Mathew, Jyotsna Hiranandani, Ava Gonick, Courtney Young, Kelly Nguyen, Nhu Phi, Jeffrey H. Miller   +10 more
wiley   +1 more source

Gender-related differences in response to mutagens and carcinogens.

Mutagenesis, 2010
The incidences of many cancers can be very different in men and women. Besides differences in exposures to putative causative agents, it is plausible that both genetic and epigenetic effects play roles in these differences.
Micheline Kirsch-Volders, Stefano Bonassi, Z. Herceg, Ari Hirvonen, Lennart Möller, David H. Phillips   +5 more
semanticscholar   +1 more source

Food Toxicology and Safety: Evaluating Dietary Risks and Functional Ingredients

Food Bioengineering, EarlyView.
The pyramid's foundation reminds us that true health begins with daily habits—engage in 30–60 min of physical activity, nurture social connections and secure 7–9 h of restorative sleep each night to support metabolism, mood regulation, and hormonal balance—while continuously hydrating with 8–12 glasses of water and unsweetened herbal infusions (green ...
Sujaritha Jayaraj, Lavanya Kothandan, Vijay Babu Murugan, Saravana Kumar Prakash, Vandhana Vijayakumar, Elizabeth Rani   +5 more
wiley   +1 more source

Evaluation of the Sedative Activity of Naringenin: In Vivo Study with Pharmacokinetics and Molecular Docking Insights

ChemistryOpen, EarlyView.
The study investigates the sedative potential of naringenin (NAR) through in vivo and in silico approaches. NAR significantly enhances sleep duration and reduces latency in mice, especially when combined with diazepam. Molecular docking shows strong binding to GABAA receptors, suggesting a GABAergic mechanism.
Dipu Bishwas, Md. Shimul Bhuia, Salehin Sheikh, Mohammed Alfaifi, Abdul Malik, Nikhat J. Siddiqui, Divya Jain, Mehedi Hasan Bappi, Muhammad Torequl Islam   +8 more
wiley   +1 more source

Induced floral heteromorphism in Petunia hybrida

Acta Societatis Botanicorum Poloniae, 2014
Floral heteromorphism induced in Petunia hybrida with several chemical mutagens and gamma-radiation is discussed. Potentials of these mutagens in inducing various forms are described.
S. G. Kashikar, A. S. Khalatkar
doaj   +1 more source

A WHO 2021‐based comprehensive scheme outlining sperm parameters’ associations with IVF outcomes in PGT‐A cycles

Andrology, EarlyView.
Abstract Objective To examine the association between semen parameters, assessed according to World Health Organization (WHO)‐2021 criteria, and paternal body mass index (BMI) and age, with embryological and clinical outcomes in ICSI cycles involving preimplantation genetic testing for aneuploidy (PGT‐A).
Rossella Mazzilli, Danilo Cimadomo, Federica Innocenti, Marilena Taggi, Greta Chiara Cermisoni, Sara Ginesi, Lisa Dovere, Laura Albricci, Maurizio Guido, Maria Rosaria Campitiello, Susanna Ferrero, Antonio Capalbo, Alberto Vaiarelli, Filippo Maria Ubaldi, Alberto Ferlin, Laura Rienzi, Gianluca Gennarelli   +16 more
wiley   +1 more source

Antimutagenic effect of genistein

Czech Journal of Food Sciences, 2006
A great variety of health benefits including the protection against breast and prostate cancers has been attributed to the soya consumption, because of the presence of soy beans isoflavones, genistein, and others. We investigated the antigenotoxic effect
Zdeňka Polívková, Martina Langová, Petr Šmerák, Jiřina Bártová, Ivo Bárta   +4 more
doaj   +1 more source

What spatial omics is teaching us about field cancerisation in prostate and bladder cancer

BJU International, EarlyView.
Background and Objectives Field cancerisation is the process that results in a group of cells acquiring some of the phenotypic changes of cancer prior to transformation into cancer. Clinically, an important challenge remains the ability to distinguish clonal lineages and microenvironments within cancerised fields that will remain indolent from those ...
Matthew H. V. Byrne, Thineskrishna Anbarasan, Lisa Browning, Dan J. Woodcock   +3 more
wiley   +1 more source

Transcription‐coupled repair: tangled up in convoluted repair

The FEBS Journal, EarlyView.
In this review, we discuss recent findings derived from diverse genomic, biochemical and structural, imaging, and functional studies (B–E) that culminated in deep mechanistic insight (A) into the vital cellular process of transcription‐coupled nucleotide excision repair (TC‐NER).
Diana A. Llerena Schiffmacher, Yun Jin Pai, Alex Pines, Wim Vermeulen   +3 more
wiley   +1 more source

Study of the antimutagenic effects of plant polyphenols under the action of genotoxicants

Journal of Education, Health and Sport, 2019
In the test of dominant lethal germ cell mutations in male rats, the effect of phenobarbital and fluorouracil genotoxicants and their combined administration with the biotrit-C preparation, obtained from wheat seedlings and containing plant polyphenols ...
V. S. Ivanov
doaj