Results 1 to 10 of about 1,959,597 (133)

A dominant-negative FGF1 mutant (the R50E mutant) suppresses tumorigenesis and angiogenesis. [PDF]

open access: yes, 2013
Fibroblast growth factor-1 (FGF1) and FGF2 play a critical role in angiogenesis, a formation of new blood vessels from existing blood vessels. Integrins are critically involved in FGF signaling through crosstalk. We previously reported that FGF1 directly
Fujita, Masaaki   +11 more
core   +24 more sources

Proinflammatory activation of microglia in the cerebellum hyperexcites Purkinje cells to trigger ataxia

open access: yesPharmacological Research, 2023
Specific medications to combat cerebellar ataxias, a group of debilitating movement disorders characterized by difficulty with walking, balance and coordination, are still lacking.
Shu-Tao Xie   +18 more
doaj   +1 more source

Three-Dimensional X-ray Imaging of β-Galactosidase Reporter Activity by Micro-CT: Implication for Quantitative Analysis of Gene Expression

open access: yesBrain Sciences, 2021
Acquisition of detailed anatomical and molecular knowledge from intact biological samples while preserving their native three-dimensional structure is still a challenging issue for imaging studies aiming to unravel a system’s functions. Three-dimensional
Olga Ermakova   +12 more
doaj   +1 more source

An entropy-based method to measure phase-locking between LFP and spikes

open access: yesAIP Advances, 2023
Phase-locking between local field potential and spikes has been widely investigated through neurophysiological analysis. Two indices most frequently adopted traditionally include the mean resultant length and p of the Rayleigh test.
Xing-Yan Dang   +6 more
doaj   +1 more source

The contribution of maternal oral, vaginal, and gut microbiota to the developing offspring gut

open access: yesScientific Reports, 2023
There is limited understanding of how the microbiota colonizing various maternal tissues contribute to the development of the neonatal gut microbiota (GM). To determine the contribution of various maternal microbiotic sites to the offspring microbiota in
Amber L. Russell   +6 more
doaj   +1 more source

HOE DOORDACHT OM TE GAAN MET ETHISCHE VRAAGSTUKKEN?

open access: yesJournal of Social Intervention, 2020
“Als sociaal werker word je, bij de uitoefening van je vak, onvermijdelijk geconfronteerd met te nemen beslissingen. Beslissingen die niet enkel gestoeld zijn op theoretische inzichten, methodische ervaringen, correcte toepassingen van regels en codes ...
Fuusje de Graaff
doaj   +1 more source

BOEKBESPREKING DE ONGEKENDE MOGELIJKHEID VAN HET ALLEDAAGSE

open access: yesJournal of Social Intervention, 2019
Als docent van een HBO sociaal werk beoordeel ik veel eindstukken van studenten die van hun opdrachtgever de vraag kregen te onderzoeken hoe zij de sociale participatie van ouderen, jongeren, laaggeletterden, migranten of mensen met een beperking konden ...
Fuusje de Graaff
doaj   +1 more source

Mutant UBQLN2P497H in motor neurons leads to ALS-like phenotypes and defective autophagy in rats [PDF]

open access: yes, 2018
Mutations in ubiquilin2 (UBQLN2) have been linked to abnormal protein aggregation in amyotrophic lateral sclerosis (ALS). The mechanisms underlying UBQLN2-related neurodegenerative diseases remain unclear.
Chen, Tianhong   +4 more
core   +2 more sources

Mutant knots with symmetry [PDF]

open access: yes, 2007
Mutant knots, in the sense of Conway, are known to share the same Homfly polynomial. Their 2-string satellites also share the same Homfly polynomial, but in general their m-string satellites can have different Homfly polynomials for m>2.
Morton, H. R.
core   +2 more sources

Invariants of genus 2 mutants [PDF]

open access: yes, 2007
Pairs of genus 2 mutant knots can have different Homfly polynomials, for example some 3-string satellites of Conway mutant pairs. We give examples which have different Kauffman 3-variable polynomials, answering a question raised by Dunfield et al in ...
H. R. MORTON   +2 more
core   +3 more sources

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