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Distinguishing Mutant knots [PDF]

open access: yesJournal of Geometry and Physics, 2021
Knot theory is actively studied both by physicists and mathematicians as it provides a connecting centerpiece for many physical and mathematical theories. One of the challenging problems in knot theory is distinguishing mutant knots. Mutant knots are not distinguished by colored HOMFLY-PT polynomials for knots colored by either symmetric and or ...
L. Bishler   +8 more
openaire   +3 more sources

Proinflammatory activation of microglia in the cerebellum hyperexcites Purkinje cells to trigger ataxia

open access: yesPharmacological Research, 2023
Specific medications to combat cerebellar ataxias, a group of debilitating movement disorders characterized by difficulty with walking, balance and coordination, are still lacking.
Shu-Tao Xie   +18 more
doaj   +1 more source

Three-Dimensional X-ray Imaging of β-Galactosidase Reporter Activity by Micro-CT: Implication for Quantitative Analysis of Gene Expression

open access: yesBrain Sciences, 2021
Acquisition of detailed anatomical and molecular knowledge from intact biological samples while preserving their native three-dimensional structure is still a challenging issue for imaging studies aiming to unravel a system’s functions. Three-dimensional
Olga Ermakova   +12 more
doaj   +1 more source

An entropy-based method to measure phase-locking between LFP and spikes

open access: yesAIP Advances, 2023
Phase-locking between local field potential and spikes has been widely investigated through neurophysiological analysis. Two indices most frequently adopted traditionally include the mean resultant length and p of the Rayleigh test.
Xing-Yan Dang   +6 more
doaj   +1 more source

The contribution of maternal oral, vaginal, and gut microbiota to the developing offspring gut

open access: yesScientific Reports, 2023
There is limited understanding of how the microbiota colonizing various maternal tissues contribute to the development of the neonatal gut microbiota (GM). To determine the contribution of various maternal microbiotic sites to the offspring microbiota in
Amber L. Russell   +6 more
doaj   +1 more source

Neonatal ketone body elevation regulates postnatal heart development by promoting cardiomyocyte mitochondrial maturation and metabolic reprogramming

open access: yesCell Discovery, 2022
Neonatal heart undergoes metabolic conversion and cell cycle arrest preparing for the increased workload during adulthood. Herein, we report that neonatal ketone body elevation is a critical regulatory factor for postnatal heart development.
Danyang Chong   +16 more
doaj   +1 more source

Functional loss of Ccdc151 leads to hydrocephalus in a mouse model of primary ciliary dyskinesia

open access: yesDisease Models & Mechanisms, 2019
Primary ciliary dyskinesia (PCD) is a genetically heterogeneous disorder affecting normal structure and function of motile cilia, phenotypically manifested as chronic respiratory infections, laterality defects and infertility.
Francesco Chiani   +7 more
doaj   +1 more source

Isolation of segmented filamentous bacteria from complex gut microbiota

open access: yesBioTechniques, 2015
Segmented filamentous bacteria (SFB) modulate the ontogeny of the immune system, and their presence can significantly affect mouse models of disease. Until recently, the inability to successfully culture SFB has made controlled studies on the mechanisms ...
Aaron C. Ericsson   +7 more
doaj   +1 more source

Mutant Insulin Syndromes [PDF]

open access: yesHormone and Metabolic Research, 1988
Highly sensitive procedures for the characterization of molecular species of insulin in the circulation and for the isolation of the gene encoding human insulin have recently been developed. Nine subjects with abnormal forms of insulin or proinsulin have been reported.
A, Vinik, G, Bell
openaire   +2 more sources

Effect of Shipping on the Microbiome of Donor Mice Used to Reconstitute Germ-Free Recipients

open access: yesGut Microbes Reports
The gut microbiome (GM) influences multiple processes during host development and maintenance. To study these events, fecal microbiota transfer (FMT) to germ-free (GF) recipients is often performed.
Zachary L. McAdams   +7 more
doaj   +1 more source

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