Results 1 to 10 of about 1,217,641 (150)

Proinflammatory activation of microglia in the cerebellum hyperexcites Purkinje cells to trigger ataxia

open access: yesPharmacological Research, 2023
Specific medications to combat cerebellar ataxias, a group of debilitating movement disorders characterized by difficulty with walking, balance and coordination, are still lacking.
Shu-Tao Xie   +18 more
doaj   +1 more source

Three-Dimensional X-ray Imaging of β-Galactosidase Reporter Activity by Micro-CT: Implication for Quantitative Analysis of Gene Expression

open access: yesBrain Sciences, 2021
Acquisition of detailed anatomical and molecular knowledge from intact biological samples while preserving their native three-dimensional structure is still a challenging issue for imaging studies aiming to unravel a system’s functions. Three-dimensional
Olga Ermakova   +12 more
doaj   +1 more source

An entropy-based method to measure phase-locking between LFP and spikes

open access: yesAIP Advances, 2023
Phase-locking between local field potential and spikes has been widely investigated through neurophysiological analysis. Two indices most frequently adopted traditionally include the mean resultant length and p of the Rayleigh test.
Xing-Yan Dang   +6 more
doaj   +1 more source

The contribution of maternal oral, vaginal, and gut microbiota to the developing offspring gut

open access: yesScientific Reports, 2023
There is limited understanding of how the microbiota colonizing various maternal tissues contribute to the development of the neonatal gut microbiota (GM). To determine the contribution of various maternal microbiotic sites to the offspring microbiota in
Amber L. Russell   +6 more
doaj   +1 more source

Studies on mutagenic effect of phosphemide in barley

open access: yesТруды по прикладной ботанике, генетике и селекции, 2022
Background. The method of induced mutagenesis is used to temporarily increase the frequency of mutations, allowing a higher probability of obtaining plants with new alleles and traits valuable for breeding.
N. V. Tetyannikov, N. A. Bome
doaj   +1 more source

Neonatal ketone body elevation regulates postnatal heart development by promoting cardiomyocyte mitochondrial maturation and metabolic reprogramming

open access: yesCell Discovery, 2022
Neonatal heart undergoes metabolic conversion and cell cycle arrest preparing for the increased workload during adulthood. Herein, we report that neonatal ketone body elevation is a critical regulatory factor for postnatal heart development.
Danyang Chong   +16 more
doaj   +1 more source

Functional loss of Ccdc151 leads to hydrocephalus in a mouse model of primary ciliary dyskinesia

open access: yesDisease Models & Mechanisms, 2019
Primary ciliary dyskinesia (PCD) is a genetically heterogeneous disorder affecting normal structure and function of motile cilia, phenotypically manifested as chronic respiratory infections, laterality defects and infertility.
Francesco Chiani   +7 more
doaj   +1 more source

Influence of UV light exposure on mineral composition and biomass production of mycomeat produced from different agricultural substrates [PDF]

open access: yesJournal of Agricultural Sciences (Belgrade), 2017
The wild and mutant strain of Pleurotus sajor caju was cultured on different agricultural substrates. Treatment 1 contained agricultural substrates alone. Treatment 2 contained the mutant strain of the mushroom plus agricultural waste. Treatment
Adejumo Isaac Oluseun   +2 more
doaj   +1 more source

Callus Irradiation Is an Effective Tool for Creating New Seashore Paspalum Germplasm for Stress Tolerance

open access: yesAgronomy, 2022
Seashore paspalum (Paspalum vaginatum Swartz) is a perennial warm-season turfgrass which is known for its superb salinity tolerance. Compared to bermudagrass, seashore paspalum exhibited the adverse character of faster vertical growth, wider leaf, weak ...
Zhuyi Bai   +7 more
doaj   +1 more source

Comparative Analysis of Volatile Compounds of Gamma-Irradiated Mutants of Rose (Rosa hybrida)

open access: yesPlants, 2020
Roses are one of the most important floricultural crops, and their essential oils have long been used for cosmetics and aromatherapy. We investigated the volatile compound compositions of 12 flower-color mutant variants and their original cultivars ...
Jaihyunk Ryu   +8 more
doaj   +1 more source

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