Results 1 to 10 of about 2,116,851 (188)

Inactivation and inducible oncogenic mutation of p53 in gene targeted pigs. [PDF]

, 2012
Mutation of the tumor suppressor p53 plays a major role in human carcinogenesis. Here we describe gene-targeted porcine mesenchymal stem cells (MSCs) and live pigs carrying a latent TP53(R167H) mutant allele, orthologous to oncogenic human mutant TP53 ...
Durkovic, Marina, Edlinger, Marlene, Flisikowska, Tatiana, Flisikowski, Krzysztof, Kessler, Barbara, Kind, Alexander, Kurome, Mayuko, Leuchs, Simon, Merkl, Claudia, Rezaei, Nousin, Saalfrank, Anja, Schnieke, Angelika, Wolf, Eckhard, Zakhartchenko, Valeri   +13 more
core   +14 more sources

Proinflammatory activation of microglia in the cerebellum hyperexcites Purkinje cells to trigger ataxia

Pharmacological Research, 2023
Specific medications to combat cerebellar ataxias, a group of debilitating movement disorders characterized by difficulty with walking, balance and coordination, are still lacking.
Shu-Tao Xie, Wen-Chu Fan, Xian-Sen Zhao, Xiao-Yang Ma, Ze-Lin Li, Yan-Ran Zhao, Fa Yang, Ying Shi, Hui Rong, Zhi-San Cui, Jun-Yi Chen, Hong-Zhao Li, Chao Yan, Qipeng Zhang, Jian-Jun Wang, Xiao-Yang Zhang, Xiao-Ping Gu, Zheng-Liang Ma, Jing-Ning Zhu   +18 more
doaj   +1 more source

Three-Dimensional X-ray Imaging of β-Galactosidase Reporter Activity by Micro-CT: Implication for Quantitative Analysis of Gene Expression

Brain Sciences, 2021
Acquisition of detailed anatomical and molecular knowledge from intact biological samples while preserving their native three-dimensional structure is still a challenging issue for imaging studies aiming to unravel a system’s functions. Three-dimensional
Olga Ermakova, Tiziana Orsini, Paolo Fruscoloni, Francesco Chiani, Alessia Gambadoro, Sabrina Putti, Maurizio Cirilli, Alessio Mezzi, Saulius Kaciulis, Miriam Pasquini, Marcello Raspa, Ferdinando Scavizzi, Glauco P. Tocchini-Valentini   +12 more
doaj   +1 more source

An entropy-based method to measure phase-locking between LFP and spikes

AIP Advances, 2023
Phase-locking between local field potential and spikes has been widely investigated through neurophysiological analysis. Two indices most frequently adopted traditionally include the mean resultant length and p of the Rayleigh test.
Xing-Yan Dang, Han-Ting Xu, Xin-Yu Bao, Yun-Yong Xie, Jing-Ning Zhu, Xiao-Yang Zhang, Xiao-Lin Huang   +6 more
doaj   +1 more source

The contribution of maternal oral, vaginal, and gut microbiota to the developing offspring gut

Scientific Reports, 2023
There is limited understanding of how the microbiota colonizing various maternal tissues contribute to the development of the neonatal gut microbiota (GM). To determine the contribution of various maternal microbiotic sites to the offspring microbiota in
Amber L. Russell, Zachary L. McAdams, Erin Donovan, Nicole Seilhamer, Melissa Siegrist, Craig L. Franklin, Aaron C. Ericsson   +6 more
doaj   +1 more source

HOE DOORDACHT OM TE GAAN MET ETHISCHE VRAAGSTUKKEN?

Journal of Social Intervention, 2020
“Als sociaal werker word je, bij de uitoefening van je vak, onvermijdelijk geconfronteerd met te nemen beslissingen. Beslissingen die niet enkel gestoeld zijn op theoretische inzichten, methodische ervaringen, correcte toepassingen van regels en codes ...
Fuusje de Graaff
doaj   +1 more source

BOEKBESPREKING DE ONGEKENDE MOGELIJKHEID VAN HET ALLEDAAGSE

Journal of Social Intervention, 2019
Als docent van een HBO sociaal werk beoordeel ik veel eindstukken van studenten die van hun opdrachtgever de vraag kregen te onderzoeken hoe zij de sociale participatie van ouderen, jongeren, laaggeletterden, migranten of mensen met een beperking konden ...
Fuusje de Graaff
doaj   +1 more source

Characterisation of a pucBA deletion mutant from Rhodopseudomonas palustris lacking all but the pucBAd genes [PDF]

, 2017
Rhodopseudomonas palustris is a species of purple photosynthetic bacteria that has a multigene family of puc genes that encode the alpha and beta apoproteins, which form the LH2 complexes.
Carey, Anne-Marie, Cogdell, Richard J., de Percin Northumberland, Claire Ortmann, Gardiner, Alastair T., Henry, Sarah L., Kelly, Sharon M., Mullen, William, Roszak, Aleksander W., Southall, June   +8 more
core   +1 more source

IKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome [PDF]

, 2009
Expansion of the polyglutamine repeat within the protein Huntingtin (Htt) causes Huntington's disease, a neurodegenerative disease associated with aging and the accumulation of mutant Htt in diseased neurons.
Aiken, Ali Khoshnan, Alice L. Lau, Ana Maria Cuervo, Anne, Apostol, Arrasate, Arrasate, Ashish Massey, Atwal, Atwal, Björkqvist, Brown, Charity T. Aiken, Chen, Chondrogianni, Cornett, Cuervo, Cuervo, Cuervo, D'Orazi, Dan, Donald C. Lo, Fang, Finkbeiner, Frank M. LaFerla, Gillian Bates, Graham, Grossman, Gu, Guerrero, Gutekunst, Hasan Khashwji, Henn, Hernandez-Hernandez, Hietakangas, Hofmann, Hu, Huang, Humbert, Hunter, J. Lawrence Marsh, Jacqueline Gire O'Rourke, Jeong, Jiang, Joan S. Steffan, Karin, Karin, Katalin Illes, Kaushik, Kazantsev, Khoshnan, Khoshnan, Kim N. Green, Komatsu, Lan Huang, Leslie Michels Thompson, Linda S. Kaltenbach, Liu, Lo, Luo, Mangiarini, Marta Martinez-Vincente, Martinez-Vicente, Massey, Massey, Michael R. Hayden, Michels, Mizushima, Montserrat Arrasate, Namita Agrawal, Orr, Paul H. Patterson, Peters-Libeu, Rockabrand, Saudou, Schilling, Scott O. Zeitlin, Shao, Southwell, Steffan, Steffan, Steffan, Steven Finkbeiner, Tagwerker, Tamas Lukacsovich, Tonoki, Verma, Walker, Warby, Warby, Warby, Wu, Xia, Ya-Zhen Zhu, Yanai, Zhang, Zuccato   +97 more
core   +3 more sources

Functional loss of Ccdc151 leads to hydrocephalus in a mouse model of primary ciliary dyskinesia

Disease Models & Mechanisms, 2019
Primary ciliary dyskinesia (PCD) is a genetically heterogeneous disorder affecting normal structure and function of motile cilia, phenotypically manifested as chronic respiratory infections, laterality defects and infertility.
Francesco Chiani, Tiziana Orsini, Alessia Gambadoro, Miriam Pasquini, Sabrina Putti, Maurizio Cirilli, Olga Ermakova, Glauco P. Tocchini-Valentini   +7 more
doaj   +1 more source