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Inactivation and inducible oncogenic mutation of p53 in gene targeted pigs. [PDF]
Mutation of the tumor suppressor p53 plays a major role in human carcinogenesis. Here we describe gene-targeted porcine mesenchymal stem cells (MSCs) and live pigs carrying a latent TP53(R167H) mutant allele, orthologous to oncogenic human mutant TP53 ...
Durkovic, Marina +13 more
core +24 more sources
Distinguishing Mutant knots [PDF]
Knot theory is actively studied both by physicists and mathematicians as it provides a connecting centerpiece for many physical and mathematical theories. One of the challenging problems in knot theory is distinguishing mutant knots. Mutant knots are not distinguished by colored HOMFLY-PT polynomials for knots colored by either symmetric and or ...
L. Bishler +8 more
openaire +3 more sources
Specific medications to combat cerebellar ataxias, a group of debilitating movement disorders characterized by difficulty with walking, balance and coordination, are still lacking.
Shu-Tao Xie +18 more
doaj +1 more source
Acquisition of detailed anatomical and molecular knowledge from intact biological samples while preserving their native three-dimensional structure is still a challenging issue for imaging studies aiming to unravel a system’s functions. Three-dimensional
Olga Ermakova +12 more
doaj +1 more source
An entropy-based method to measure phase-locking between LFP and spikes
Phase-locking between local field potential and spikes has been widely investigated through neurophysiological analysis. Two indices most frequently adopted traditionally include the mean resultant length and p of the Rayleigh test.
Xing-Yan Dang +6 more
doaj +1 more source
The contribution of maternal oral, vaginal, and gut microbiota to the developing offspring gut
There is limited understanding of how the microbiota colonizing various maternal tissues contribute to the development of the neonatal gut microbiota (GM). To determine the contribution of various maternal microbiotic sites to the offspring microbiota in
Amber L. Russell +6 more
doaj +1 more source
HOE DOORDACHT OM TE GAAN MET ETHISCHE VRAAGSTUKKEN?
“Als sociaal werker word je, bij de uitoefening van je vak, onvermijdelijk geconfronteerd met te nemen beslissingen. Beslissingen die niet enkel gestoeld zijn op theoretische inzichten, methodische ervaringen, correcte toepassingen van regels en codes ...
Fuusje de Graaff
doaj +1 more source
BOEKBESPREKING DE ONGEKENDE MOGELIJKHEID VAN HET ALLEDAAGSE
Als docent van een HBO sociaal werk beoordeel ik veel eindstukken van studenten die van hun opdrachtgever de vraag kregen te onderzoeken hoe zij de sociale participatie van ouderen, jongeren, laaggeletterden, migranten of mensen met een beperking konden ...
Fuusje de Graaff
doaj +1 more source
Invariants of genus 2 mutants [PDF]
Pairs of genus 2 mutant knots can have different Homfly polynomials, for example some 3-string satellites of Conway mutant pairs. We give examples which have different Kauffman 3-variable polynomials, answering a question raised by Dunfield et al in ...
H. R. MORTON +2 more
core +3 more sources
Mutant knots with symmetry [PDF]
Mutant knots, in the sense of Conway, are known to share the same Homfly polynomial. Their 2-string satellites also share the same Homfly polynomial, but in general their m-string satellites can have different Homfly polynomials for m>2.
Morton, H. R.
core +2 more sources

