Results 1 to 10 of about 2,654,030 (335)
On the establishment of a mutant [PDF]
Journal of Mathematical Biology, 2020 AbstractHow long does it take for an initially advantageous mutant to establish itself in a resident population, and what does the population composition look like then? We approach these questions in the framework of the so called Bare Bones evolution model (Klebaner et al. in J Biol Dyn 5(2):147–162, 2011.https://doi.org/10.1080/17513758.2010.506041)
Jeremy Baker +3 more
openaire +5 more sources
Vorasidenib in IDH1- or IDH2-Mutant Low-Grade Glioma.
New England Journal of Medicine, 2023 BACKGROUND Isocitrate dehydrogenase (IDH)-mutant grade 2 gliomas are malignant brain tumors that cause considerable disability and premature death.
I. Mellinghoff +29 more
semanticscholar +1 more source
Blood, 2022 Substantial heterogeneity within mutant TP53 acute myeloid leukemia (AML) and myelodysplastic syndrome with excess of blast (MDS-EB) precludes the exact assessment of prognostic impact for individual patients. We performed in-depth clinical and molecular
T. Grob +19 more
semanticscholar +1 more source
Pharmacological Research, 2023 Specific medications to combat cerebellar ataxias, a group of debilitating movement disorders characterized by difficulty with walking, balance and coordination, are still lacking.
Shu-Tao Xie +18 more
doaj +1 more source
Brain Sciences, 2021 Acquisition of detailed anatomical and molecular knowledge from intact biological samples while preserving their native three-dimensional structure is still a challenging issue for imaging studies aiming to unravel a system’s functions. Three-dimensional
Olga Ermakova +12 more
doaj +1 more source
Targeting mutant p53 for cancer therapy: direct and indirect strategies
Journal of Hematology & Oncology, 2021 TP53 is a critical tumor-suppressor gene that is mutated in more than half of all human cancers. Mutations in TP53 not only impair its antitumor activity, but also confer mutant p53 protein oncogenic properties.
Jiahao Hu +9 more
semanticscholar +1 more source
An entropy-based method to measure phase-locking between LFP and spikes
AIP Advances, 2023 Phase-locking between local field potential and spikes has been widely investigated through neurophysiological analysis. Two indices most frequently adopted traditionally include the mean resultant length and p of the Rayleigh test.
Xing-Yan Dang +6 more
doaj +1 more source
Cell, 2017 The development of CRISPR/Cas9-mediated gene knockout in two ant species opens a new window into exploring how social insects use olfactory cues to organize their collective behavior.
Daniel A. Friedman +3 more
openaire +3 more sources
The contribution of maternal oral, vaginal, and gut microbiota to the developing offspring gut
Scientific Reports, 2023 There is limited understanding of how the microbiota colonizing various maternal tissues contribute to the development of the neonatal gut microbiota (GM). To determine the contribution of various maternal microbiotic sites to the offspring microbiota in
Amber L. Russell +6 more
doaj +1 more source
Cell Discovery, 2022 Neonatal heart undergoes metabolic conversion and cell cycle arrest preparing for the increased workload during adulthood. Herein, we report that neonatal ketone body elevation is a critical regulatory factor for postnatal heart development.
Danyang Chong +16 more
doaj +1 more source