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Evaluating Random Mutant Selection at Class-Level in Projects with Non-Adequate Test Suites [PDF]
Proceedings of the 20th International Conference on Evaluation and
Assessment in Software Engineering (EASE '16). ACM, New York, NY, USA, 2016, 2016 Mutation testing is a standard technique to evaluate the quality of a test suite. Due to its computationally intensive nature, many approaches have been proposed to make this technique feasible in real case scenarios. Among these approaches, uniform random mutant selection has been demonstrated to be simple and promising.
Demeyer, Serge +2 more
arxiv +3 more sources
Invariants of genus 2 mutants [PDF]
J.Knot Theor.Ramifications 18:1423-1438,2009, 2007 Pairs of genus 2 mutant knots can have different Homfly polynomials, for example some 3-string satellites of Conway mutant pairs. We give examples which have different Kauffman 3-variable polynomials, answering a question raised by Dunfield et al in their study of genus 2 mutants.
H. R. MORTON +2 more
arxiv +5 more sources
The gut microbiome switches mutant p53 from tumour-suppressive to oncogenic
Nature, 2020 Somatic mutations in p53, which inactivate the tumour-suppressor function of p53 and often confer oncogenic gain-of-function properties, are very common in cancer 1 , 2 .
Eli Pikarsky +2 more
exaly +2 more sources
Genetic compensation triggered by mutant mRNA degradation
Nature, 2019 Genetic robustness, or the ability of an organism to maintain fitness in the presence of harmful mutations, can be achieved via protein feedback loops. Previous work has suggested that organisms may also respond to mutations by transcriptional adaptation,
Mohamed A El-brolosy +2 more
exaly +2 more sources
Mutant knots with symmetry [PDF]
Mathematical Proceedings of the Cambridge Philosophical Society, 2009 AbstractMutant knots, in the sense of Conway, are known to share the same Homfly polynomial. Their 2-string satellites also share the same Homfly polynomial, but in general theirm-string satellites can have different Homfly polynomials form> 2.
Morton, H. R.
openaire +6 more sources
Phenotypic mixing and hiding may contribute to memory in viral quasispecies [PDF]
BMC Microbiology 3:11 (2003), 2003 Background. In a number of recent experiments with food-and-mouth disease virus, a deleterious mutant, was found to avoid extinction and remain in the population for long periods of time. This observation was called quasispecies memory. The origin of quasispecies memory is not fully understood. Results.
Novella, Isabel S., Wilke, Claus O.
arxiv +7 more sources
A combinatorial strategy for treating KRAS-mutant lung cancer
Nature, 2016 Therapeutic targeting of KRAS-mutant lung adenocarcinoma represents a major goal of clinical oncology. KRAS itself has proved difficult to inhibit, and the effectiveness of agents that target key KRAS effectors has been thwarted by activation of ...
Chi-chao Chen +2 more
exaly +2 more sources
Mutant Kras copy number defines metabolic reprogramming and therapeutic susceptibilities
Nature, 2016 The RAS/MAPK (mitogen-activated protein kinase) signalling pathway is frequently deregulated in non-small-cell lung cancer, often through KRAS activating mutations.
Emma M Kerr +2 more
exaly +2 more sources
A dominant-negative FGF1 mutant (the R50E mutant) suppresses tumorigenesis and angiogenesis. [PDF]
, 2013 Fibroblast growth factor-1 (FGF1) and FGF2 play a critical role in angiogenesis, a formation of new blood vessels from existing blood vessels. Integrins are critically involved in FGF signaling through crosstalk. We previously reported that FGF1 directly
Fujita, Masaaki +11 more
core +20 more sources