Results 221 to 230 of about 2,913,254 (384)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Analysis of the catalyic mechanism of a fungal lipase using computer-aided design and structural mutants [PDF]

, 1996
H. de Beer, Gerd Wohlfahrt, John E.G. McCarthy, Dietmar Schomburg, Rolf D. Schmid   +4 more
openalex   +1 more source

Thermostability engineering of microbial transglutaminase using artificial intelligence and investigation of its underlying mechanisms. [PDF]

Bioresour Bioprocess
Song X, Han K, Xu P, Zheng J, Cai J.
europepmc   +1 more source

MUTANT FUZZY SETS

, 2019
WOS ...
openaire   +3 more sources

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

OA 12.01 The Preclinical and Clinical Activity of Poziotinib, a Potent, Selective Inhibitor of EGFR Exon 20 Mutant NSCLC [PDF]

, 2017
Yasir Y. Elamin, Jacqulyne Robichaux, Vincent K. Lam, Anne S. Tsao, Chien‐Hsing Lu, George Blumenschein, Jonathan M. Kurie, Julie R. Brahmer, S. Li, Ting Chen, Adriana Estrada‐Bernal, Anna Truini, Monique B. Nilsson, Anh T. Le, Zhi Tan, Shaozeng Zhang, Robert C. Doebele, Katerina Politi, Zane Yang, S. Liu, Kah Keng Wong, John V. Heymach   +21 more
openalex   +1 more source

Extracellular vesicles from stem cells rescue cellular phenotypes and behavioral deficits in SHANK3-associated ASD neuronal and mouse models. [PDF]

Cell Death Dis
Choudhary A, Rosh I, Hussein Y, Netser S, Shemen A, Suliman T, Rike WA, Simchi L, Shklyar B, Abu-Akel A, Zinger A, Offen D, Wagner S, Stern S.   +13 more
europepmc   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Etude de l'ATPase CA + du reticulum sarco/endoplasmique (mise au point d'une nouvelle méthode de purification de SERCA1A de lapin exprimée chez S. cerevisiae permettant sa cristallisation et applications au mutant E309Q. Etude d'une autre isoforme SERCA3A )

, 2005
Marie Habets Jidenko, LE MAIRE, Marc
openalex   +1 more source

BRAF inhibitor resistance in melanoma: from resistance mechanisms to therapeutic innovations. [PDF]

Mol Biomed
Shang Y, Cao T, Li J, Li J, Zhang L, Ma Q, Feng L, Zhao H.   +7 more
europepmc   +1 more source