Molecular Oncology, EarlyView.Human cytomegalovirus infection is common in normal prostate epithelium, prostate tumor tissue, and prostate cancer cell lines. CMV promotes cell survival, proliferation, and androgen receptor signaling. Anti‐CMV pharmaceutical compounds in clinical use inhibited cell expansion in prostate cancer models in vitro and in vivo, motivating investigation ...
Johanna Classon +13 more
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Three positively charged binding sites on the eastern equine encephalitis virus E2 glycoprotein coordinate heparan sulfate- and protein receptor-dependent infection. [PDF]
Nat CommunAlcorn MDH +8 more
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Molecular Oncology, EarlyView.In luminal (ER+) breast carcinoma (BC), miRNA profiling identified miR‐195‐5p as a key regulator of proliferation that targets CHEK1, CDC25A, and CCNE1. High CHEK1 expression correlates with worse relapse‐free survival after chemotherapy, especially in patients with luminal A subtype.
Veronika Boušková +14 more
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THE INHERITANCE OF THE MUTANT CHARACTER "VORTEX" [PDF]
, 1919 Calvin B. Bridges, Otto L. Mohr
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Histone acetylation readers Bdf1 and Yaf9 direct SWR1 remodeler to +1 nucleosome. [PDF]
Sci AdvRanjan A +11 more
europepmc +1 more source
Molecular Oncology, EarlyView.In thyroid cancer patients, high‐dose (≥7.4 GBq) radioactive iodine therapy (RAIT) was associated with a higher prevalence of clonal hematopoiesis (variant allele frequency >2%) in individuals aged ≥50 years (OR = 2.44). In silico analyses showed that truncating PPM1D mutations conferred a selective advantage under these conditions.
Jaeryuk Kim +11 more
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ISOLATION AND STUDY OF MUTANTS FROM MAMMALIAN CELLS IN CULTURE [PDF]
, 1959 Irving Lieberman, Peter Ove
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Functional divergence of conserved developmental plasticity genes between two distantly related nematodes. [PDF]
Sci RepWighard S, Witte H, Sommer RJ.
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ITGAV and SMAD4 influence the progression and clinical outcome of pancreatic ductal adenocarcinoma
Molecular Oncology, EarlyView.In SMAD4‐positive pancreatic ductal adenocarcinoma (PDAC), integrin subunit alpha V (ITGAV) activates latent TGF‐β, which binds to the TGF‐β receptor and phosphorylates SMAD2/3. The activated SMAD2/3 forms a complex with SMAD4, and together they translocate to the nucleus, modulating gene expression to promote proliferation, migration, and invasion. In
Daniel K. C. Lee +9 more
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A DEVELOPMENTAL ANALYSIS OF THE LETHAL MUTANT L(2)GL OF DROSOPHILA MELANOGASTER BASED ON CYTOPHOTOMETRIC DETERMINATION OF NUCLEAR DESOXYRIBONUCLEIC ACID (DNA) CONTENT [PDF]
, 1957 Robert M. Welch
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