Results 221 to 230 of about 1,179,318 (342)

Ubiquitination of transcription factors in cancer: unveiling therapeutic potential

Molecular Oncology, EarlyView.
In cancer, dysregulated ubiquitination of transcription factors contributes to the uncontrolled growth and survival characteristics of tumors. Tumor suppressors are degraded by aberrant ubiquitination, or oncogenic transcription factors gain stability through ubiquitination, thereby promoting tumorigenesis.
Dongha Kim, Hye Jin Nam, Sung Hee Baek
wiley   +1 more source

A zinc finger protein shapes the temperature adaptability of a cosmopolitan pest. [PDF]

Open Biol
Miao X, Cao F, Yu XF, Li TP, Su HY, Guo J, Hu GL, Chen BW, You MS, Liu YY, Lei GK, You S.   +11 more
europepmc   +1 more source

The Development of a Pupal Lethal Mutant inDrosophila [PDF]

, 1959
H. H. El Shatoury
openalex   +1 more source

CD44v, S1PR1, HER3, MET and cancer‐associated amino acid transporters are promising targets for the pancreatic cancers characterized using mAb

FEBS Open Bio, EarlyView.
Novel mAbs could detect cancer‐associated membrane proteins on various type of pancreatic ductal adenocarcinomas (PDAC) by flow cytometry with viable PDAC cells and by immunohistochemistry with PDAC tissues. Results of protein expression were substantiated by mRNA expression by The Cancer Genome Atlas.
Takashi Nakano, Kouki Okita, Shogo Okazaki, Soshi Yoshimoto, Sachiko Masuko, Hideki Yagi, Kazunori Kato, Yoshihisa Tomioka, Kenichi Imai, Yoichi Hamada, Kazue Masuko, Kayoko Shimada‐Takaura, Noriaki Nagai, Hideyuki Saya, Tomio Arai, Toshiyuki Ishiwata, Takashi Masuko   +16 more
wiley   +1 more source

Neuroprotective role of Hippo signaling by microtubule stability control in <i>Caenorhabditis elegans</i>. [PDF]

Elife
Lee H, Kang J, Lee SH, Lee D, Chung CH, Lee J.   +5 more
europepmc   +1 more source

Gene Interactions: the Mode of Action of the Suppressor of Acetate-requiring Mutants of Neurospora crassa

, 1954
Bernard S. Strauss, Steffen Pierog
openalex   +1 more source

Evaluation of synaptotagmin‐1 action models by all‐atom molecular dynamics simulations

FEBS Open Bio, EarlyView.
We used molecular dynamics simulations to test models proposing that synaptotagmin‐1 facilitates membrane fusion by perturbing lipid bilayers, inducing membrane curvature and/or bridging membranes. The simulations show that synaptotagmin‐1 C2‐domains placed near the site of fusion hinder the ability of SNARE complexes to bring the membranes together ...
Josep Rizo, Klaudia Jaczynska, Christian Rosenmund   +2 more
wiley   +1 more source

Temporal transcriptome analysis reveals the two-phase action of florigens in rice flowering. [PDF]

Theor Appl Genet
Sun R, Ding Y, Mimura M, Nishide N, Izawa T.   +4 more
europepmc   +1 more source

BIOCHEMICAL CHARACTERISTICS OF ALDEHYDE AND LUCIFERASE MUTANTS OF LUMINOUS BACTERIA

, 1955
Palmer Rogers, W. D. McElroy
openalex   +1 more source

Pharmacological effects of osimertinib on a chicken chorioallantoic membrane xenograft model with the EGFR exon‐19‐deleted advanced NSCLC mutation

FEBS Open Bio, EarlyView.
Osimertinib reduces angiogenesis and PDL1 expression in in ovo tumors, transforming them into ‘cold tumors’ with lower immune activity. Anatomopathological and transcriptomic analyses highlight its therapeutic impact on tumor biology. This study underscores osimertinib's potential to reshape the tumor microenvironment and provides insights into its ...
David Barthélémy, Arnaud Vigneron, Xavier Rousset, Jérome Guitton, Emmanuel Grolleau, Margaux Raffin, Julie Balandier, Gaëlle Lescuyer, Mathilde Bardou, Florence Geiguer, Sébastien Couraud, Claire Bardel, Jean Viallet, Nazim Benzerdjeb, Léa Payen   +14 more
wiley   +1 more source