Results 31 to 40 of about 2,692,923 (420)

NHEJ protects mycobacteria in stationary phase against the harmful effects of desiccation [PDF]

, 2007
The physiological role of the non-homologous end-joining (NHEJ) pathway in the repair of DNA double-strand breaks (DSBs) was examined in Mycobacterium smegmatis using DNA repair mutants (DeltarecA, Deltaku, DeltaligD, Deltaku/ligD, DeltarecA/ku/ligD ...
Brzostek, A., Doherty, Aidan, Dziadek, J., Green, A. J., Korycka-Machala, M., Pitcher, R. S.   +5 more
core   +1 more source

Parthenocarpic tomato mutants, iaa9-3 and iaa9-5, show plant adaptability and fruiting ability under heat-stress conditions

Frontiers in Plant Science, 2023
Fruit set is one of the main problems that arise in tomato plants under heat-stress conditions, which disrupt pollen development, resulting in decreased pollen fertility.
Syariful Mubarok, Nurul Jadid, Ani Widiastuti, Deden Derajat Matra, Rahmat Budiarto, Fitrianti Widya Lestari, Anne Nuraini, Erni Suminar, Bayu Pradana Nur Rahmat, Hiroshi Ezura, Hiroshi Ezura   +10 more
doaj   +1 more source

Somatic mutant clones colonize the human esophagus with age

Science, 2018
The mutational burden of aging As people age, they accumulate somatic mutations in healthy cells. About 25% of cells in normal, sun-exposed skin harbor cancer driver mutations.
I. Martincorena, J. Fowler, Agnieszka Wabik, A. Lawson, F. Abascal, M. Hall, A. Cagan, K. Murai, Krishnaa T. Mahbubani, M. Stratton, R. Fitzgerald, P. Handford, P. Campbell, K. Saeb‐Parsy, P. Jones   +14 more
semanticscholar   +1 more source

Mutant ADA2 in Vasculopathies [PDF]

New England Journal of Medicine, 2014
n engl j med 371;5 nejm.org july 31, 2014 478 CRT-D between patients with ischemic cardiomyopathy with NYHA class I or class II and patients with nonischemic cardiomyopathy. Hazard ratios were similar in these groups (0.66, 0.65, and 0.57, respectively), which denoted a similar effect size.
Van Eyck, Lien, Liston, Adrian, Wouters, Carine   +2 more
openaire   +10 more sources

IKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome [PDF]

, 2009
Expansion of the polyglutamine repeat within the protein Huntingtin (Htt) causes Huntington's disease, a neurodegenerative disease associated with aging and the accumulation of mutant Htt in diseased neurons.
Aiken, Ali Khoshnan, Alice L. Lau, Ana Maria Cuervo, Anne, Apostol, Arrasate, Arrasate, Ashish Massey, Atwal, Atwal, Björkqvist, Brown, Charity T. Aiken, Chen, Chondrogianni, Cornett, Cuervo, Cuervo, Cuervo, D'Orazi, Dan, Donald C. Lo, Fang, Finkbeiner, Frank M. LaFerla, Gillian Bates, Graham, Grossman, Gu, Guerrero, Gutekunst, Hasan Khashwji, Henn, Hernandez-Hernandez, Hietakangas, Hofmann, Hu, Huang, Humbert, Hunter, J. Lawrence Marsh, Jacqueline Gire O'Rourke, Jeong, Jiang, Joan S. Steffan, Karin, Karin, Katalin Illes, Kaushik, Kazantsev, Khoshnan, Khoshnan, Kim N. Green, Komatsu, Lan Huang, Leslie Michels Thompson, Linda S. Kaltenbach, Liu, Lo, Luo, Mangiarini, Marta Martinez-Vincente, Martinez-Vicente, Massey, Massey, Michael R. Hayden, Michels, Mizushima, Montserrat Arrasate, Namita Agrawal, Orr, Paul H. Patterson, Peters-Libeu, Rockabrand, Saudou, Schilling, Scott O. Zeitlin, Shao, Southwell, Steffan, Steffan, Steffan, Steven Finkbeiner, Tagwerker, Tamas Lukacsovich, Tonoki, Verma, Walker, Warby, Warby, Warby, Wu, Xia, Ya-Zhen Zhu, Yanai, Zhang, Zuccato   +97 more
core   +3 more sources

Functional loss of Ccdc151 leads to hydrocephalus in a mouse model of primary ciliary dyskinesia

Disease Models & Mechanisms, 2019
Primary ciliary dyskinesia (PCD) is a genetically heterogeneous disorder affecting normal structure and function of motile cilia, phenotypically manifested as chronic respiratory infections, laterality defects and infertility.
Francesco Chiani, Tiziana Orsini, Alessia Gambadoro, Miriam Pasquini, Sabrina Putti, Maurizio Cirilli, Olga Ermakova, Glauco P. Tocchini-Valentini   +7 more
doaj   +1 more source

Identification by enzyme immunoassay of escape mutants S143L and G145R of hepatitis B virus (Hepadnaviridae: Orthohepadnavirus: Hepatitis B virus)

Вопросы вирусологии, 2022
Introduction. The achievement of the goal of the World Health Organization to eliminate viral hepatitis B by 2030 seems to be problematic partly due to the presence of escape mutants of its etiological agent, hepatitis B virus (HBV) (iHepadnaviridae ...
M. V. Konopleva, A. A. Feldsherova, D. A. Elgort, T. A. Tupoleva, N. A. Kokhanovskaya, V. N. Pankratova, T. A. Semenenko, A. P. Suslov   +7 more
doaj   +1 more source

Genetic Analysis and Fine Mapping of a Spontaneously Mutated Male Sterility Gene in Brassica rapa ssp. chinensis

G3: Genes, Genomes, Genetics, 2020
Male sterility has been widely used in hybrid seed production in Brassica, but not in B. rapa ssp. chinensis, and genetic models of male sterility for this subspecies are unclear. We discovered a spontaneous mutant in B. rapa ssp. chinensis.
Tzu-Kai Lin, Ya-Ping Lin, Shun-Fu Lin
doaj   +1 more source

HER kinase inhibition in patients with HER2- and HER3-mutant cancers

Nature, 2018
Somatic mutations of ERBB2 and ERBB3 (which encode HER2 and HER3, respectively) are found in a wide range of cancers. Preclinical modelling suggests that a subset of these mutations lead to constitutive HER2 activation, but most remain biologically ...
David M. Hyman, S. Piha-Paul, H. Won, J. Rodón, C. Saura, Geoffrey I. Shapiro, D. Juric, David I. Quinn, V. Moreno, B. Doger, I. Mayer, V. Boni, E. Calvo, S. Loi, A. C. Lockhart, J. Erinjeri, M. Scaltriti, G. Ulaner, J. Patel, Jiabin Tang, H. Beer, S. D. Selcuklu, Aphrothiti J. Hanrahan, N. Bouvier, Myra Melcer, R. Murali, A. Schram, L. Smyth, K. Jhaveri, Bob T. Li, A. Drilon, J. Harding, G. Iyer, Barry S. Taylor, Michael F. Berger, R. Cutler, Feng Xu, A. Butturini, L. Eli, G. Mann, C. Farrell, A. Lalani, R. Bryce, Carlos L. Arteaga, F. Meric-Bernstam, J. Baselga, D. Solit   +46 more
semanticscholar   +1 more source

Mutant p53 as a guardian of the cancer cell

Cell Death and Differentiation, 2018
Forty years of research have established that the p53 tumor suppressor provides a major barrier to neoplastic transformation and tumor progression by its unique ability to act as an extremely sensitive collector of stress inputs, and to coordinate a ...
F. Mantovani, Licio Collavin, G. Del Sal
semanticscholar   +1 more source