Results 51 to 60 of about 2,088,899 (353)
Mutant loxP vectors for selectable marker recycle and conditional knock-outs [PDF]
, 2001 BACKGROUND: Gene disruption by targeted integration of transfected constructs becomes increasingly popular for studies of gene function. The chicken B cell line DT40 has been widely used as a model for gene knock-outs due to its high targeted integration
Arakawa, Hiroshi +2 more
core +3 more sources
Isolation and pathogenic characterization of duck adenovirus 3 mutant circulating in China
Poultry Science, 2022 : Duck adenoviruses (DAdVs) include serotype 1 (DAdV-1) in the genus Atadenovirus and serotypes 2-4 (DAdV-2, 3, and 4) in the genus Aviadenovirus. DAdV-3 was initially isolated from Chinese Muscovy ducks in 2014, whereby the infected ducks exhibited ...
Xinjin Shi +8 more
doaj
Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
FEBS Letters, EarlyView.This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source
Mutant Insulin Syndromes [PDF]
Hormone and Metabolic Research, 1988 Highly sensitive procedures for the characterization of molecular species of insulin in the circulation and for the isolation of the gene encoding human insulin have recently been developed. Nine subjects with abnormal forms of insulin or proinsulin have been reported.
G Bell, Aaron I. Vinik
openaire +2 more sources
Making tau amyloid models in vitro: a crucial and underestimated challenge
FEBS Letters, EarlyView.This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley +1 more source
Familial ALS-superoxide dismutases associate with mitochondria and shift their redox potentials [PDF]
, 2006 Recent studies suggest that the toxicity of familial amyotrophic lateral sclerosis mutant Cu, Zn superoxide dismutase (SOD1) arises from its selective recruitment to mitochondria. Here we demonstrate that each of 12 different familial ALS-mutant SOD1s
Butler Gralla, Edith +8 more
core +2 more sources
Cell Death and DiseaseOverexpression of mitotic arrest deficiency 2 (MAD2/MAD2L1), a pivotal component of the spindle assembly checkpoint (SAC), resulted in many types of cancer.
Yao Xi +14 more
doaj +1 more source
Pathogenicity of FtsK mutant of avian pathogenic Escherichia coli
Journal of Veterinary Research, 2016 Introduction: Avian pathogenic Escherichia coli (APEC) is a leading cause of extraintestinal infection and heavy economic losses. Imparting immunity after vaccination with live attenuated strain vaccination is an ideal strategy for infection control ...
Xu Xiaojing +3 more
doaj +1 more source
Brazilian Archives of Biology and Technology, 2018 Screening promising L. thermophiles with high productivity, high efficiency and strong adaptability are very important in lactic acid industry. For this purpose, 80MeV/u carbon ions were applied to irradiate L. thermophiles.
Wei Hu +6 more
doaj +1 more source
Primary root growth, tissue expression and co-expression analysis of a receptor kinase mutant in Arabidopsis [PDF]
Journal of Plant Molecular Breeding, 2014 There is no functional annotation for the majority of the several hundreds of receptor-like kinases in plants. A direct way of inferring the function of these proteins is to study the phenotype that results from loss of function mutants such as T-DNA ...
Hamid Najafi zarrini +1 more
doaj +1 more source