Results 51 to 60 of about 2,913,254 (384)

Concurrent RB1 and TP53 alterations define a subset of EGFR-mutant lung cancers at risk for histologic transformation and inferior clinical outcomes.

Journal of Thoracic Oncology, 2019
INTRODUCTION EGFR-mutant lung cancers are clinically and genomically heterogeneous with concurrent RB1/TP53 alterations identifying a subset at increased risk for small cell transformation.
M. Offin, J. Chan, M. Tenet, H. Rizvi, R. Shen, Gregory Riely, N. Rekhtman, Y. Daneshbod, Á. Quintanal-Villalonga, A. Penson, M. Hellmann, M. Arcila, M. Ladanyi, D. Pe’er, M. Kris, C. Rudin, H. Yu   +16 more
semanticscholar   +1 more source

The Efficacy and Safety of Bevacizumab/Irinotecan/Temozolomide (BIT) for Relapsed/Refractory Neuroblastoma: The UK Children's Cancer and Leukaemia Group Experience

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Patients with high‐risk neuroblastoma who either are refractory to induction chemotherapy or relapse following multi‐modal treatment have a dismal prognosis. Based on data from the BEACON trial, since 2021 the UK national guidelines recommend bevacizumab, irinotecan, and temozolomide (BIT) for patients with relapsed/refractory ...
Thomas J. Jackson, Menna Shamma, Upeka Senanayake, Shaimaa Sahmoud, Kathleen Duffin, Victoria Howard, David King, Ayesha Fathani, Blanche Lumb, Andrei Pobischan, Irum Latif Memon, Monzir Ahmed, Rhian Thomas, Gerard Millen, Yasmeen Alomari, Sucheta Vaidya, Lynley V. Marshall, Sally L. George, Ramya Ramanujachar, Juliet Gray, Paola Angelini   +20 more
wiley   +1 more source

Deletion of N-acetylmuramyl-L-alanine amidases alters the host immune response to Mycobacterium tuberculosis infection

Virulence, 2021
Peptidoglycan (PG), a heteropolysaccharide component of the mycobacterial cell wall can be shed during tuberculosis infection with immunomodulatory consequences.
Nathan Scott Kieswetter, Mumin Ozturk, Shelby-Sara Jones, Sibusiso Senzani, Melissa Dalcina Chengalroyen, Frank Brombacher, Bavesh Kana, Reto Guler   +7 more
doaj   +1 more source

Isolation and pathogenic characterization of duck adenovirus 3 mutant circulating in China

Poultry Science, 2022
: Duck adenoviruses (DAdVs) include serotype 1 (DAdV-1) in the genus Atadenovirus and serotypes 2-4 (DAdV-2, 3, and 4) in the genus Aviadenovirus. DAdV-3 was initially isolated from Chinese Muscovy ducks in 2014, whereby the infected ducks exhibited ...
Xinjin Shi, Xinyu Zhang, Haiwei Sun, Changqing Wei, Yingnan Liu, Jiguan Luo, Xuebo Wang, Zongyan Chen, Hongjun Chen   +8 more
doaj   +1 more source

Shank3 mutant mice display autistic-like behaviours and striatal dysfunction

Nature, 2011
Autism spectrum disorders (ASDs) comprise a range of disorders that share a core of neurobehavioural deficits characterized by widespread abnormalities in social interactions, deficits in communication as well as restricted interests and repetitive ...
J. Peça, C. Feliciano, J. Ting, Wenting Wang, Michael F. Wells, T. Venkatraman, C. Lascola, Z. Fu, G. Feng   +8 more
semanticscholar   +1 more source

Rapid Response to Trametinib Combined With Chemotherapy for Infant BRAF‐Fused Chiasmatic Glioma

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Infants, less than 1 year, with chiasmatic gliomas (ICG) present a major therapeutic challenge due to large tumor size, decreased vision, rapid progression, and poor response to vincristine/carboplatin chemotherapy. The majority have a BRAF fusion, which may respond to downstream MEK inhibitors but response time is slow. There are no safety or
Helen Toledano, Alexander Yelak, Walid Kaadan, Shlomo Caduri, Rivka Friedland, Orli Michaeli, Gad Dotan, Osnat Konen   +7 more
wiley   +1 more source

Evolution and clinical impact of co-occurring genetic alterations in advanced-stage EGFR-mutant lung cancers

Nature Genetics, 2017
A widespread approach to modern cancer therapy is to identify a single oncogenic driver gene and target its mutant-protein product (for example, EGFR-inhibitor treatment in EGFR-mutant lung cancers).
C. Blakely, T. Watkins, Wei Wu, B. Gini, J. Chabon, C. McCoach, N. Mcgranahan, G. Wilson, Nicolai J. Birkbak, V. Olivas, J. Rotow, A. Maynard, V. Wang, M. Gubens, K. Banks, R. Lanman, Aleah F. Caulin, J. St. John, Anibal Cordero, P. Giannikopoulos, A. Simmons, P. Mack, D. Gandara, H. Husain, R. Doebele, J. Riess, M. Diehn, C. Swanton, T. Bivona   +28 more
semanticscholar   +1 more source

Construction of an Influenza D Virus with an Eight-Segmented Genome

Viruses, 2021
Influenza D virus (IDV) may cause the bovine respiratory disease complex, which is the most common and costly disease affecting the cattle industry. Previously, we revealed that eight segments could be actively packaged in its single virion, suggesting ...
Hiroho Ishida, Shin Murakami, Haruhiko Kamiki, Hiromichi Matsugo, Misa Katayama, Wataru Sekine, Kosuke Ohira, Akiko Takenaka-Uema, Taisuke Horimoto   +8 more
doaj   +1 more source

Empirical Evaluation of Mutation-based Test Prioritization Techniques

, 2018
We propose a new test case prioritization technique that combines both mutation-based and diversity-based approaches. Our diversity-aware mutation-based technique relies on the notion of mutant distinguishment, which aims to distinguish one mutant's ...
Bae, Doo-Hwan, Papadakis, Mike, Shin, Donghwan, Yoo, Shin   +3 more
core   +2 more sources

Mutant p53R270H drives altered metabolism and increased invasion in pancreatic ductal adenocarcinoma [PDF]

, 2018
Pancreatic cancer is characterized by nearly universal activating mutations in KRAS. Among other somatic mutations, TP53 is mutated in more than 75% of human pancreatic tumors.
Daylan, Ayse Ece Cali, Del Vecchio, Annachiara, Espinoza, Carlos, Fabo, Tania, Fearon, Eric R., Feng, Ying, Galbán, Stefanie, Halbrook, Christopher J., Karim, Saadia A., Kovalenko, Ilya, Kremer, Daniel M., Kumar-Sinha, Chandan, Lee, Ho-Joon, Ljungman, Mats, Lyssiotis, Costas A., Magnuson, Brian, Morton, Jennifer P., Pasca di Magliano, Marina, Schofield, Heather K., Yan, Wei, Zeller, Jörg   +20 more
core   +1 more source