Results 61 to 70 of about 2,828,087 (336)

Sequencing Targeted and Immune Therapy in BRAF-Mutant Melanoma: Lessons Learned [PDF]

, 2023
Claudia Trojaniello, Francesca Sparano, Eleonora Cioli, Paolo A. Ascierto   +3 more
openalex   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Generation and Characterization of a Foxtail Millet (Setaria italica) Mutant Library

Frontiers in Plant Science, 2019
Foxtail millet (Setaria italica) is attractive to plant scientists as a model plant because of several distinct characteristics, such as its short stature, rapid life cycle, sufficient seed production per plant, self-compatibility, true diploid nature ...
Jing Sun, Ngoc Sinh Luu, Zhenhua Chen, Bing Chen, Xuean Cui, Jinxia Wu, Zhiguo Zhang, Tiegang Lu   +7 more
doaj   +1 more source

Characterization of the extracellular lipase of Bacillus subtilis and its relationship to a membrane-bound lipase found in a mutant strain [PDF]

, 1979
Bacillus subtilis CMK33 is a mutant that is more osmotically fragile than the wild type when it is converted to the protoplast form. The protoplasts of this mutant contain a membrane-bound lipase, which is not found in protoplasts of the wild type ...
Kennedy, Mary B., Lennarz, W. J.
core  

Small molecule induced reactivation of mutant p53 in cancer cells [PDF]

, 2013
The p53 cancer mutant Y220C is an excellent paradigm for rescuing the function of conformationally unstable p53 mutants because it has a unique surface crevice that can be targeted by small-molecule stabilizers.
Adams, Alan R. Fersht, Andreas C. Joerger, Boeckler, Brown, Bullock, Bullock, Chipuk, Chuckowree, Cook, Dearth, Di Como, Emsley, Endo, Foster, Gannon, Green, Hengartner, Irina S. Chuckowree, Jahangir Amin, Joerger, Joerger, Joerger, Joerger, John Spencer, Johnson, Kaar, Kabsch, Kojima, Kojima, Lambert, Lane, Legros, Leslie, Liu, Newhouse, Oda, Petitjean, Rainer Wilcken, Rippin, Speidel, Spencer, Spencer, Spencer, Spencer, Spencer, Taylor, Van Maerken, Vassilev, Villunger, Vousden, Walerych, Wang, Wattel, Wilcken, Wilcken, Wolter, Xiangrui Liu, Yu   +58 more
core   +2 more sources

Shank3 mutant mice display autistic-like behaviours and striatal dysfunction

Nature, 2011
Autism spectrum disorders (ASDs) comprise a range of disorders that share a core of neurobehavioural deficits characterized by widespread abnormalities in social interactions, deficits in communication as well as restricted interests and repetitive ...
J. Peça, C. Feliciano, J. Ting, Wenting Wang, Michael F. Wells, T. Venkatraman, C. Lascola, Z. Fu, G. Feng   +8 more
semanticscholar   +1 more source

Plasmodium falciparum gametogenesis essential protein 1 (GEP1) is a transmission‐blocking target

FEBS Letters, EarlyView.
This study shows Plasmodium falciparum GEP1 is vital for activating sexual stages of malarial parasites even independently of a mosquito factor. Knockout parasites completely fail gamete formation even when a phosphodiesterase inhibitor is added. Two single‐nucleotide polymorphisms (V241L and S263P) are found in 12%–20% of field samples.
Frederik Huppertz, Milagros Siebeck Caturelli, Lina S. Lehmann, Florian Kurth, Alexander G. Maier, Kai Matuschewski   +5 more
wiley   +1 more source

Structural implications of BK polyomavirus sequence variations in the major viral capsid protein Vp1 and large T-antigen: a computational study

mSphere
BK polyomavirus (BKPyV) is a double-stranded DNA virus causing nephropathy, hemorrhagic cystitis, and urothelial cancer in transplant patients. The BKPyV-encoded capsid protein Vp1 and large T-antigen (LTag) are key targets of neutralizing antibodies and
Janani Durairaj, Océane M. Follonier, Karoline Leuzinger, Leila T. Alexander, Maud Wilhelm, Joana Pereira, Caroline A. Hillenbrand, Fabian H. Weissbach, Torsten Schwede, Hans H. Hirsch   +9 more
doaj   +1 more source

Characterization of avirulent mutant Legionella pneumophila that survive but do not multiply within human monocytes. [PDF]

, 1987
Legionella pneumophila, the causative agent of Legionnaires' disease, is a Gram-negative bacterium and a facultative intracellular parasite that multiplies in human monocytes and alveolar macrophages. In this paper, mutants of L.
Horwitz, MA
core  

Lipoprotein lipase regulates hematopoietic stem progenitor cell maintenance through DHA supply. [PDF]

, 2018
Lipoprotein lipase (LPL) mediates hydrolysis of triglycerides (TGs) to supply free fatty acids (FFAs) to tissues. Here, we show that LPL activity is also required for hematopoietic stem progenitor cell (HSPC) maintenance.
Han, Tianxu, Kim, Jungsu, Klemke, Richard L, Liu, Chao, Miller, Yury I, Rana, Tariq M, Remaley, Alan T, Stachura, David L, Traver, David, Vaisman, Boris L, Wang, Huawei   +10 more
core   +2 more sources