Results 71 to 80 of about 2,828,087 (336)

4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase in malaria parasites and enhances atovaquone efficacy

FEBS Letters, EarlyView.
Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer, Matheus Felipe Santos, Maurício Mazzine Filho, Gabriela Oliveira Castro, Agustín Hernández, Manoel Aparecido Peres, Alejandro Miguel Katzin, Marcell Crispim   +7 more
wiley   +1 more source

‘Miyagawa’ New Bud Mutant Type: Enhances Resistance to Low-Temperature Stress

Agronomy
Global climate change is leading to more frequent extreme cold events, underscoring the need to study citrus cold tolerance to support breeding and enable potential northward expansion of citrus cultivation.
Shuangyou Wang, Yingzi Zhang, Ben Zhang, Weiqi Luo, Xiang Liu, Suming Dai, Dazhi Li, Na Li   +7 more
doaj   +1 more source

The Mutagenesis of Lactobacillus Thermophilus for Enhanced L-(+)-Lactic Acid Accumulation Induced by Heavy Ion Irradiation

Brazilian Archives of Biology and Technology, 2018
Screening promising L. thermophiles with high productivity, high efficiency and strong adaptability are very important in lactic acid industry. For this purpose, 80MeV/u carbon ions were applied to irradiate L. thermophiles.
Wei Hu, Jihong Chen, Qinghua Wu, Wenjian Li, Jing Liu, Dong Lu, Shuyang Wang   +6 more
doaj   +1 more source

The ubiquitin-proteasome pathway in Huntington's disease. [PDF]

, 2008
The accumulation of mutant protein is a common feature of neurodegenerative disease. In Huntington's disease, a polyglutamine expansion in the huntingtin protein triggers neuronal toxicity.
Finkbeiner, Steven, Mitra, Siddhartha
core   +2 more sources

Linked dimers of the AAA+ ATPase Msp1 reveal energetic demands and mechanistic plasticity for substrate extraction from lipid bilayers

FEBS Letters, EarlyView.
Cells must clear mislocalized or faulty proteins from membranes to survive. The AAA+ ATPase Msp1 performs this task, but dissecting how its six subunits work together is challenging. We engineered linked dimers with varied numbers of functional subunits to reveal how Msp1 subunits cooperate and use energy to extract proteins from the lipid bilayer ...
Deepika Gaur, Brian Acquaviva, Baylee A. Smith, Nathan Walker, Isabella Walter, Matthew L. Wohlever   +5 more
wiley   +1 more source

Comprehensive mapping and modelling of the rice regulome landscape unveils the regulatory architecture underlying complex traits

Nature Communications
Unraveling the regulatory mechanisms that govern complex traits is pivotal for advancing crop improvement. Here we present a comprehensive regulome atlas for rice (Oryza sativa), charting the chromatin accessibility across 23 distinct tissues from three ...
Tao Zhu, Chunjiao Xia, Ranran Yu, Xinkai Zhou, Xingbing Xu, Lin Wang, Zhanxiang Zong, Junjiao Yang, Yinmeng Liu, Luchang Ming, Yuxin You, Dijun Chen, Weibo Xie   +12 more
doaj   +1 more source

Intraperitoneal infection of A/J and CD1 mice with coxsackievirus B2 and its mutants

Acta Virologica
Coxsackieviruses (CVs) belong to the genus Enterovirus and family Picornaviridae. Mutants can arise within the replication cycle of RNA viruses. The prototype CVB2 Ohio-1 (CVB2/O) strain adapted to rhabdomyosarcoma (RD) cells induced cytolytic infection ...
Maria Borsanyiova, Katarina Berakova, Brigita Benkoova, Michaela Pellerova, A. Michael Lindberg, Shubhada Bopegamage   +5 more
doaj   +1 more source

Identification of Two New Mechanisms That Regulate Fruit Growth by Cell Expansion in Tomato

Frontiers in Plant Science, 2017
Key mechanisms controlling fruit weight and shape at the levels of meristem, ovary or very young fruit have already been identified using natural tomato diversity. We reasoned that new developmental modules prominent at later stages of fruit growth could
Constance Musseau, Daniel Just, Joana Jorly, Frédéric Gévaudant, Annick Moing, Christian Chevalier, Martine Lemaire-Chamley, Christophe Rothan, Lucie Fernandez   +8 more
doaj   +1 more source

Clathrin Heavy Chain subunits coordinate endo- and exocytic traffic and affect stomatal movement [PDF]

, 2017
The current model for vesicular traffic to and from the plasma membrane is accepted but the molecular requirements for this coordination are not well defined.
Blatt, Michael R., Larson, Emily R., Marion-Poll, Annie, Roux, Camille, Van Zelm, Eva   +4 more
core   +2 more sources

Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma

Nature, 2010
B-RAF is the most frequently mutated protein kinase in human cancers. The finding that oncogenic mutations in BRAF are common in melanoma, followed by the demonstration that these tumours are dependent on the RAF/MEK/ERK pathway, offered hope that ...
G. Bollag, P. Hirth, J. Tsai, Jiazhong Zhang, P. Ibrahim, Hanna Cho, W. Spevak, Chao Zhang, Ying Zhang, G. Habets, Elizabeth A. Burton, B. Wong, Garson Tsang, B. West, Ben J. Powell, Rafe Shellooe, A. Marimuthu, Hoa T. Nguyen, Kam Y. J. Zhang, D. Artis, J. Schlessinger, F. Su, B. Higgins, R. Iyer, K. D’Andrea, A. Koehler, M. Stumm, P. Lin, Richard J Lee, J. Grippo, I. Puzanov, Kevin B. Kim, A. Ribas, G. McArthur, J. Sosman, P. Chapman, K. Flaherty, Xiaowei Xu, K. Nathanson, K. Nolop   +39 more
semanticscholar   +1 more source