Results 71 to 80 of about 4,355,944 (375)
Choosing Mutation and Crossover Ratios for Genetic Algorithms - A Review with a New Dynamic Approach
Inf., 2019 Genetic algorithm (GA) is an artificial intelligence search method that uses the process of evolution and natural selection theory and is under the umbrella of evolutionary computing algorithm.
Ahmad Hassanat +5 more
semanticscholar +1 more source
FEBS Letters, EarlyView.Cells must clear mislocalized or faulty proteins from membranes to survive. The AAA+ ATPase Msp1 performs this task, but dissecting how its six subunits work together is challenging. We engineered linked dimers with varied numbers of functional subunits to reveal how Msp1 subunits cooperate and use energy to extract proteins from the lipid bilayer ...
Deepika Gaur +5 more
wiley +1 more source
DNA-dependent protein kinase: Epigenetic alterations and the role in genomic stability of cancer [PDF]
, 2019 DNA-dependent protein kinase (DNA-PK), a member of phosphatidylinositol-kinase family, is a key protein in mammalian DNA double-strand break (DSB) repair that helps to maintain genomic integrity.
Ansari, Shabbir Ahmed +13 more
core +1 more source
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Adaptations Accumulated under Prolonged Resource Exhaustion Are Highly Transient
mSphere, 2020 Many nonsporulating bacterial species can survive for years within exhausted growth media in a state termed long-term stationary phase (LTSP). We have been carrying out evolutionary experiments aimed at elucidating the dynamics of genetic adaptation ...
Sarit Avrani +2 more
doaj +3 more sources
The Importance of DNA Repair in Tumor Suppression
, 2004 The transition from a normal to cancerous cell requires a number of highly specific mutations that affect cell cycle regulation, apoptosis, differentiation, and many other cell functions.
B. Vogelstein +8 more
core +1 more source
Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
Cluster tilting modules for mesh algebras
, 2020 We study cluster tilting modules in mesh algebras of Dynkin type, providing a new proof for their existence. In all but one case, we show that these are precisely the maximal rigid modules, and that they are equivariant for a certain automorphism.
Erdmann, Karin +2 more
core +1 more source
The Genetic Basis of Mutation Rate Variation in Yeast. [PDF]
, 2018 Mutations are the root source of genetic variation and underlie the process of evolution. Although the rates at which mutations occur vary considerably between species, little is known about differences within species, or the genetic and molecular basis ...
Bloom, Joshua S +2 more
core +1 more source
CCT4 promotes tunneling nanotube formation
FEBS Letters, EarlyView.Tunneling nanotubes (TNTs) are membranous tunnel‐like structures that transport molecules and organelles between cells. They vary in thickness, and thick nanotubes often contain microtubules in addition to actin fibers. We found that cells expressing monomeric CCT4 generate many thick TNTs with tubulin.
Miyu Enomoto +3 more
wiley +1 more source