Results 191 to 200 of about 1,757,426 (287)

Benzo[b]fluoranthene Induces Mutation Accumulation and Cancer-Relevant Mutational Signatures in Mouse Lung Alongside Steady State Levels of Chromosome Damage in Blood. [PDF]

Environ Mol Mutagen
Zhang X, Hobbs CA, Rivas MV, Diesing A, LeBlanc DPM, Zhou G, Foley JF, White PA, Marchetti F, Yauk CL, Smith-Roe SL.   +10 more
europepmc   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Copy number and sequence variation in ribosomal DNA and the transposon, Pokey, in mutation accumulation lines of Daphnia obtusa. [PDF]

G3 (Bethesda)
Elguweidi A, Crease TJ.
europepmc   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Mutation accumulation following extended exposure of human HepaRG cells to a genotoxic carcinogen. [PDF]

J Environ Sci Health C Toxicol Carcinog
Guo X, Seo JE, Miranda-Colon J, Xu H, Revollo J, Heflich RH.   +5 more
europepmc   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Induced somatic mutation accumulation during skeletal muscle regeneration reduces muscle strength. [PDF]

Nat Aging
Vrtačnik P, Merino LG, Subhash S, Helgadóttir HT, Bardin M, Stefani F, Wang D, Chen P, Franco I, Revêchon G, Eriksson M.   +10 more
europepmc   +1 more source

Das Intelligente Genom über die Entstehung des menschlichen Geistes durch Mutation und Selektion

, 1999
The Intelligent Genome: On the Formation of Human Intelligence via Mutation and Selection, by A.
Wendt, Dirk
core  

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Mutation rate and spectrum in obligately outcrossing Caenorhabditis elegans mutation accumulation lines subjected to RNAi-induced knockdown of the mismatch repair gene msh-2. [PDF]

G3 (Bethesda), 2022
Katju V, Konrad A, Deiss TC, Bergthorsson U.   +3 more
europepmc   +1 more source