Results 201 to 210 of about 1,757,426 (287)

Mutations affecting accumulation of glycogen

Fungal Genetics Reports, 1973
M. A. Morales, A. J. Jobaggy, H. F. Terenzi   +2 more
openaire   +2 more sources

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Trends of Mutation Accumulation Across Global SARS-CoV-2 Genomes: Implications for the Evolution of the Novel Coronavirus [PDF]

Genomics, 2020
Roy C, Mandal SM, Mondol SK, Mukherjee S, Ghosh W, Chakraborty R.   +5 more
europepmc   +2 more sources

Effect of copper and nickel exposure on ribosomal DNA variation in Daphnia pulex mutation accumulation lines. [PDF]

G3 (Bethesda)
Elguweidi A, Cristescu ME, Crease TJ.
europepmc   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Assessing mutation accumulation in DNA repair-deficient <i>Listeria monocytogenes</i>: implications for cgMLST cluster thresholds in outbreak analysis. [PDF]

Front Cell Infect Microbiol
Füszl A, Pietzka A, Hyden P, Mösenbacher T, Stöger A, Blaschitz M, Stadlbauer S, Hasenberger P, Schindler S, Heger F, Pleininger S, Indra A.   +11 more
europepmc   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

An estimate of fitness reduction from mutation accumulation in a mammal allows assessment of the consequences of relaxed selection. [PDF]

PLoS Biol
Chebib J, Jonas A, López-Cortegano E, Künzel S, Tautz D, Keightley PD.   +5 more
europepmc   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

Dissection of the mutation accumulation process during bacterial range expansions. [PDF]

BMC Genomics, 2020
Bosshard L, Peischl S, Ackermann M, Excoffier L.   +3 more
europepmc   +1 more source