Results 51 to 60 of about 27,093,662 (158)

MicroRNA‐130a‐3p Targets the Androgen‐Related Transcription Factor MAFB: Effects on Proliferation, Migration, Apoptosis, and Cell Cycle in Hypospadias

Pediatric Discovery, EarlyView.
MicroRNA‐130a‐3p targets and inhibits MAFB expression, leading to the development of hypospadimas. MicroRNA‐130a‐3p inhibits the expression of MAFB, disrupts the normal processes of cell proliferation, migration, cell apoptosis, and cycle progression, and ultimately leads to the development of hypospadias.
Jiaxin Zhou, Yixuan Wang, Zhicheng Zhang, Qiang Zhang, Zhenmin Liu, Hongsong Chen, Xingguo Luo, Chunlan Long, Lianju Shen, Xing Liu, Guanghui Wei   +10 more
wiley   +1 more source

Functional characterization of the DNA mismatch binding protein MutS from Haemophilus influenzae

, 2005
This investigation demonstrates DNA mismatch repair activity in Haemophilus influenzae cell free extracts. The mutS gene as well as purified protein of H.
Duppatla, Viswanadham, Rao, Desirazu N., Joseph, Nimesh   +2 more
core   +1 more source

Genome-Wide Proteomics and Quantitative Analyses on Halophilic Archaea [PDF]

, 2008
The aerobic, haloalkaliphilic archaeon Natronomonas pharaonis is able to survive in salt-saturated lakes of pH 11. With genome-wide shotgun proteomics, 886 soluble proteins (929 proteins in total) of the theoretical Natronomonas pharaonis soluble ...
Konstantinidis, Konstantinos, Konstantinidis, K.   +1 more
core   +1 more source

Identification of Yeast Protein Sequences With Similarity to the ESCRT‐III Protein Snf7

Yeast, EarlyView.
ABSTRACT Endosomal sorting complex required for transport (ESCRT‐III) is a membrane remodeling complex involved in a large number of cellular processes. It appears to perform an essential function in eukaryotes, since to date no eukaryotic organism completely devoid of ESCRT‐III has been found.
Thomas Brune, Ralf Kölling
wiley   +1 more source

A new subtype of Lynch syndrome associated with MSH2 c.354T>A (p. Y118*) identified in a Chinese family: case report and literature review

Frontiers in Genetics
BackgroundLynch syndrome (LS) is an autosomal dominant inherited disorder caused by mutations in mismatch repair genes. Genetic counseling is crucial for the prevention and treatment of LS, as individuals with these mutations have an increased lifetime ...
Lan Zhong, Lan Zhong, Wenxiang Wang, Wenxiang Wang, Wenxiang Wang, Yuanqiong Duan, Yuanqiong Duan, Liang Song, Liang Song, Zhanghuan Li, Kaixuan Yang, Qintong Li, Rutie Yin, Rutie Yin   +13 more
doaj   +1 more source

What Happens After Menopause (WHAM)? A Progress Report of a Prospective Controlled Study of Women After Pre‐Menopausal Risk‐Reducing Bilateral Salpingo‐Oophorectomy

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Surgical menopause, the removal of both ovaries prior to natural menopause, may impact short‐and long‐term physical and emotional health. An increasingly common cause of surgical menopause is risk‐reducing salpingo‐oophorectomy (RRSO) in those at high inherited risk of ovarian cancer.
Sarah A. L. Price, Pauline M. Maki, Samar R. El Khoudary, Alison Brand, Rakibul M. Islam, Susan M. Domchek, Hadine Joffe, Gita D. Mishra, Katrina M. Moss, Fiona C. Baker, Sabine Braat, John D. Wark, Martha Hickey   +12 more
wiley   +1 more source

Rustless translation [PDF]

, 2012
ATP binding cassette proteins are a large and diverse family of molecular machines and include transmembrane transporter, chromosome maintenance and DNA repair proteins, and translation factors.
Hopfner, Karl-Peter
core   +1 more source

Inhibition of TGM2 enhances cisplatin sensitivity in MSH2-deficient bladder cancer

Cell Death Discovery
MSH2 (mutS homolog 2) gene, a key component of the DNA mismatch repair system, garners significant attention for its influence on cancer progression and prognosis.
Wenjie Wei, Xingyuan Xiao, Chao Ren, Hui Zhang, Jiayin Sun, Miao Wang, Liang Wang, Hebing Chen, Guosong Jiang, Chao Huang   +9 more
doaj   +1 more source

The H19/miR‐760/BST2 regulatory axis sustains breast cancer tumorigenesis and metastasis

The FEBS Journal, EarlyView.
H19 and BST2 promote breast cancer aggressiveness through their reciprocal coregulation by miR‐760. Since both transcripts are targeted by miR‐760, overexpression of one sequesters the microRNA and relieves repression of the other: H19 raises BST2 levels, and BST2 raises H19 levels.
Kekely Klouyovo, Evodie Peperstraete, Léa Mabille, Joséphine Louvieaux, Jim Marmuse, Clément Lecerf, Chann Lagadec, Xuefen Le Bourhis, Éric Adriaenssens   +8 more
wiley   +1 more source

Mouse MutS-like protein Msh5 is required for proper chromosome synapsis in male and female meiosis

, 1999
Members of the mammalian mismatch repair protein family of MutS and MutL homologs have been implicated in postreplicative mismatch correction and chromosome interactions during meiotic recombination. Here we demonstrate that mice carrying a disruption in
te Riele, H., de Vries, S.S., Baart, E. B., Baart, E.B., de Vries, S. S., de rooij, D. G., de Boer, P., Siezen, A., Dekker, M., de Rooij, D.G.   +9 more
core   +1 more source