Results 31 to 40 of about 27,093,662 (158)

Histone H3K18 Lactylation Promotes the Malignant Progression of Wilms Tumor via a PSRC1/AKT/HIF‐1α Positive Feedback Loop

Advanced Science, EarlyView.
In nephroblastoma, aberrant glycolysis drives lactate accumulation, which elevates histone H3K18 lactylation via p300. Lactylation of the PSRC1 promoter activates its transcription. PSRC1 competitively binds AKT, relieving PTEN‐mediated inhibition and triggering AKT/mTOR/HIF‐1α signaling.
Yanping Wang, Hongjie Gao, Bifei Zhang, Xuetian Li, Ding Li, Aihua Cao, Fengyin Sun   +6 more
wiley   +1 more source

Immunohistochemical Expression of MutS Homolog 6 (MSH6) and Postmeiotic Segregation 2 (PMS2) and Their Association with Clinicopathological Features in Colorectal Carcinoma: A Cross-sectional Study [PDF]

National Journal of Laboratory Medicine
Introduction: Colorectal Carcinoma (CRC) is a gastrointestinal malignancy arising from colon or rectum. Adenocarcinoma is the most common type of CRC. It is one of the most commonly diagnosed cancer worldwide, ranking third only to lung cancer and female
Jasmine Kaur, Manas Madan, Manisha Sharma, Karamjit Gill, Shahaan Sharma   +4 more
doaj   +1 more source

A Rare De Novo Missense Mutation in IFT122 Confers a Genetic Susceptibility Factor of Idiopathic Pediatric Uveitis Via Trio‐based Whole‐Exome Sequencing

Advanced Science, EarlyView.
A rare de novo IFT122‐A773E variant is identified in idiopathic pediatric uveitis and shown to exacerbate retinal inflammation and barrier dysfunction. Mechanistically, the variant enhances IFT43 interaction, elevates calcium signaling, and activates the MEK/ERK/FRA1 axis, revealing a previously unrecognized cilia‐associated pathway that may increase ...
Qian Zhou, Jiaxing Huang, Yilin Wang, Xingran Li, Xianyang Liu, Lingyu Dai, Hongshun Li, Qingfeng Wang, Jiangyi Liu, Guannan Su, Wanyun Zhang, Yang Deng, Qingfeng Cao, Yujie Lai, Xiang Luo, Changwei Huang, Ling Chen, Shengping Hou, Peizeng Yang   +18 more
wiley   +1 more source

Histone Deacetylase 10 Regulates DNA Mismatch Repair and May Involve the Deacetylation of MutS Homolog 2

, 2015
Background: The DNA mismatch repair protein MutS homolog 2 (MSH2) is an acetylated protein. Results: Histone deacetylase 10 (HDAC10) interacts with MSH2 and deacetylates MSH2 at Lys-73, which might stimulate MSH2 activity. Conclusion: HDAC10 promotes DNA
Yuan, Fenghua, Yuan, Zhigang, Radhakrishnan, Rangasudhagar, Seto, Edward, Telles, Elphine, Lane, William S, Xiang, Shengyan, Fang, Jia, Zhang, Xiaohong, Coppola, Domenico, Shibata, David, Li, Yixuan, Zhang, Yanbin   +12 more
core   +1 more source

Conditionally Significant eQTL and TWAS Analyses Identify MsRD26 as a Major Candidate Positive Regulator of Salt Tolerance in Medicago sativa L

Advanced Science, EarlyView.
Salt stress significantly impacts plant growth. Through population transcriptome, eQTL and TWAS analyses, we identified several candidate genes potentially associated with salt stress response. Functional assays suggested that some of these genes may contribute to salt tolerance.
Lin Chen, Yuqi Zhang, Xinyue Ma, Jinpeng Bi, Fei He, Li Zhao, Haiyue Lei, Zhengqin Xiao, Xue Wang, Tiejun Zhang, Ruicai Long, Junmei Kang, Qingchuan Yang   +12 more
wiley   +1 more source

MicroRNA-21 induces resistance to 5-fluorouracil by down-regulating human DNA MutS homolog 2 (hMSH2)

, 2010
The overexpression of microRNA-21 (miR-21) is linked to a number of human tumors including colorectal cancer, where it appears to regulate the expression of tumor suppressor genes including p21, phosphatase and tensin homolog, TGFβ receptor II, and B ...
F. Lovat, Lovat, Francesca, Carlo M. Croce, Dino Amadori, Fishel, Richard, Francesca Lovat, Pierluigi Gasparini, Nicola Valeri, Muller Fabbri, C. M. Croce, Nuovo, Gerard J., D. Amadori, Valeri, Nicola, C. Braconi, Tushar Patel, Croce, Carlo M., T. Patel, PAONE, ALESSIO, Richard Fishel, K. M. Sumani, N. Valeri, M. Fabbri, Fabbri, Muller, G. J. Nuovo, Alessio Paone, Gasparini, Pierluigi, Sumani, Khela M., Amadori, Dino, Braconi, Chiara, Gerard J. Nuovo, Hansjuerg Alder, P. Gasparini, Khlea M. Sumani, Patel, Tushar, H. Alder, Chiara Braconi, Alder, Hansjuerg, R. Fishel   +37 more
core   +1 more source

Potential Influence of Age and Diabetes Mellitus Type 1 on MSH2 (MutS homolog 2) Expression in a Rat Kidney Tissue

, 2022
Background: Homeostasis of proliferating tissues is strongly dependent on intact DNA. Both neoplastic and non-neoplastic diseases have been associated with MSH2 (MutS homolog 2, a mismatch repair protein) deficiency.
Puljak, Livia, Katarina Vukojević, Babić, Paško, Paško Babić, Lejla Ferhatović Hamzić, Filipović, Natalija, Hamzić, Lejla Ferhatović, Natalija Filipović, Benjamin Benzon, Livia Puljak, Benzon, Benjamin, Vukojević, Katarina   +11 more
core   +1 more source

ZBTB18 Dysfunction Promotes Neuropathic Pain via CHD4‐based Epigenetic Disinhibition of CLIC1 Channels in Sensory Neurons

Advanced Science, EarlyView.
In this study, we identify a novel functional role of ZBTB18 in regulating trigeminal‐mediated neuropathic pain. Nerve injury reduces ZBTB18 in trigeminal ganglion neurons, impairing CHD4/NuRD recruitment and de‐repressing Clic1. Elevated CLIC1 enhances chloride channel activity and neuronal hyperexcitability, thereby driving pain.
Shoupeng Wang, Zitong Huang, Yu Tao, Yunmei Zhang, Yufang Sun, Dongsheng Jiang, Weiwei Lu, Fuhai Ji, Gang Chen, Min Xu, Yuan Zhang, Jin Tao   +11 more
wiley   +1 more source

ACSL4‐Dependent Lysosomal Lipid Peroxidation Links WTAP‐Mediated m6A Modification to Intervertebral Disc Degeneration

Advanced Science, EarlyView.
IL‐1β upregulates the protein level of WTAP, which promotes the m6A modification of ACSL4 mRNA in an IGF2BP2‐dependent manner, thereby enhancing its stability. The increased ACSL4 drives lipid peroxidation, leading to lysosomal membrane permeabilization (LMP) and impaired mitophagy, which collectively accelerate intervertebral disc degeneration (IVDD).
Shu Jia, Xu Gao, Laimin Zhu, Haixia Song, Jing Wu, Shang Chen, Sheng Gao, Lu Zhang, Chunyang Meng   +8 more
wiley   +1 more source

Studying protein-protein interactions using peptide arrays [PDF]

, 2010
Screening of arrays and libraries of compounds is well-established as a high-throughput method for detecting and analyzing interactions in both biological and chemical systems. Arrays and libraries can be composed from various types of molecules, ranging
Rito, T., Rudiger, S.G.D., Sub Cellular Protein Chemistry, Rotem-Bamberger, S., Katz, C., Friedler, A., Levy-Beladev, L., Cellular Protein Chemistry   +7 more
core   +1 more source