Results 31 to 40 of about 10,290 (158)

DNA repair mechanisms and gametogenesis [PDF]

, 2001
In mammals, there is a complex and intriguing relationship between DNA repair and gametogenesis. DNA repair mechanisms are involved not only in the repair of different types of DNA damage in developing germline cells, but ...
Baarends, W.M. (Willy), Grootegoed, J.A. (Anton), Laan, R. (Roald) van der   +2 more
core   +2 more sources

Meiotic double strand breaks repair in sexually reproducing eukaryotes: We are not all equal. [PDF]

, 2012
The defining event of meiosis is prophase-I, during which the maternal and paternal chromosome find each other in the nucleus, pair, and align in a process called “synapses of the homologues”. Their faithful segregation during the first meiotic division (
Barchi, M, La Volpe, A
core   +1 more source

DNA repair in the trinucleotide repeat disorders [PDF]

, 2017
Background Inherited diseases caused by unstable repeated DNA sequences are rare, but together represent a substantial cause of morbidity. Trinucleotide repeat disorders are severe, usually life-shortening, neurological disorders caused by nucleotide ...
Houlden, Henry, Jones, Lesley, Tabrizi, Sarah J.   +2 more
core   +2 more sources

MSH3 protein expression and nodal status in MLH1-deficient colorectal cancers. [PDF]

, 2012
View the MathML source: Colorectal tumors manifesting high-frequency microsatellite instability (MSI-H) develop genetically as a consequence of mutations in genes harboring repetitive DNA sequences.
Bianchi, P, Capella, C, Celesti, G, Chiaravalli, Am, Delconte, G, Di Caro, G, Jung, B, Laghi, L, Malesci, A., Pedroni, Monica, Ponz De Leon, Maurizio   +10 more
core   +1 more source

Monosodium glutamate-induced alterations in MMR protein expression: A potential mechanism linking diet and colorectal cancer

Gastroenterology & Endoscopy
Background: Defective mismatch repair (MMR) proteins activate the microsatellite instability (MSI) pathway, contributing to colon carcinogenesis. Monosodium glutamate (MSG), a widely used flavor enhancer, has been implicated in colorectal cancer (CRC ...
Meenakshi Sundari Rajendran, Rajkumar Prabhakaran, Padma Malini Ravi   +2 more
doaj   +1 more source

Comparison of Microsatellite Instability (MSI) and Microsatellite Stable (MSS) Invasive Breast Carcinoma Cases In Terms Of Neoadjuvant Chemotherapy Response, ER/PR Status, CerbB2, and Ki-67

İstanbul Medical Journal
Introduction: Microsatellite instability (MSI) is a well-established biomarker in certain malignancies; however, its prognostic and predictive role in breast cancer remains unclear. This study aimed to compare invasive breast carcinoma cases with MSI and
Özgecan Gündoğar, Sibel Bektaş, Emine Yıldırım, Merve Cin, Selçuk Cin, Canan Kelten Talu   +5 more
doaj   +1 more source

Transcriptome sequencing of Crucihimalaya himalaica (Brassicaceae) reveals how Arabidopsis close relative adapt to the Qinghai-Tibet Plateau [PDF]

, 2016
The extreme environment of the Qinghai-Tibet Plateau (QTP) provides an ideal natural laboratory for studies on adaptive evolution. Few genome/transcriptome based studies have been conducted on how plants adapt to the environments of QTP compared to ...
Guan, Yanlong, Han, Xi, Huang, Jinling, NC DOCKS at East Carolina University, Qiao, Qin, Sun, Hang, Wang, Qia, Zhang, Ticao, Zhong, Yang   +8 more
core   +2 more sources

Accuracy of four mononucleotide-repeat markers for the identification of DNA mismatch-repair deficiency in solid tumors

Journal of Translational Medicine, 2018
Background To screen tumors with microsatellite instability (MSI) arising due to DNA mismatch repair deficiency (dMMR), a panel of five quasi-monomorphic mononucleotide-repeat markers amplified in a multiplex PCR (Pentaplex) are commonly used.
Yuko Takehara, Takeshi Nagasaka, Akihiro Nyuya, Tomoko Haruma, Junko Haraga, Yoshiko Mori, Keiichiro Nakamura, Toshiyoshi Fujiwara, C. Richard Boland, Ajay Goel   +9 more
doaj   +1 more source

A Computational Approach to Estimating Nondisjunction Frequency in Saccharomyces cerevisiae. [PDF]

, 2016
Errors segregating homologous chromosomes during meiosis result in aneuploid gametes and are the largest contributing factor to birth defects and spontaneous abortions in humans.
Burgess, Sean M, Chu, Daniel B
core   +3 more sources

Clinical exome performance for reporting secondary genetic findings. [PDF]

, 2014
BACKGROUND : Reporting clinically actionable incidental genetic findings in the course of clinical exome testing is recommended by the American College of Medical Genet- ics and Genomics (ACMG).
Clark, P, Fortina, Paolo, Kricka, Lj, Londin, E, Park, J. Y., Park, Jy, Sponziello, Marialuisa   +6 more
core   +1 more source