Results 11 to 20 of about 5,812 (165)

Comparison of Microsatellite Instability (MSI) and Microsatellite Stable (MSS) Invasive Breast Carcinoma Cases In Terms Of Neoadjuvant Chemotherapy Response, ER/PR Status, CerbB2, and Ki-67 [PDF]

İstanbul Medical Journal
Introduction: Microsatellite instability (MSI) is a well-established biomarker in certain malignancies; however, its prognostic and predictive role in breast cancer remains unclear. This study aimed to compare invasive breast carcinoma cases with MSI and
Özgecan Gündoğar, Sibel Bektaş, Emine Yıldırım, Merve Cin, Selçuk Cin, Canan Kelten Talu   +5 more
doaj   +3 more sources

Andrias davidianus Ranavirus (ADRV) Genome Replicate Efficiently by Engaging Cellular Mismatch Repair Protein MSH2 [PDF]

Viruses, 2022
As nucleocytoplasmic large DNA viruses, replication of ranaviruses (genus Ranavirus, family Iridoviridae) involves a series of viral and host proteins.
Fei Ke, Renbao Wang, Zihao Wang, Qiya Zhang   +3 more
doaj   +2 more sources

Development of Complementary Photo‐arginine/lysine to Promote Discovery of Arg/Lys hPTMs Interactomes [PDF]

Advanced Science
Arginine and lysine, frequently appearing as a pair on histones, have been proven to carry diverse modifications and execute various epigenetic regulatory functions.
Yu Zong, Nicole Weiss, Ke Wang, Alexandra E. Pagano, Søren Heissel, Sumera Perveen, Jian Huang   +6 more
doaj   +2 more sources

Potential Influence of Age and Diabetes Mellitus Type 1 on MSH2 (MutS homolog 2) Expression in a Rat Kidney Tissue [PDF]

, 2022
Background: Homeostasis of proliferating tissues is strongly dependent on intact DNA. Both neoplastic and non-neoplastic diseases have been associated with MSH2 (MutS homolog 2, a mismatch repair protein) deficiency.
Puljak, Livia, Katarina Vukojević, Babić, Paško, Paško Babić, Lejla Ferhatović Hamzić, Filipović, Natalija, Hamzić, Lejla Ferhatović, Natalija Filipović, Benjamin Benzon, Livia Puljak, Benzon, Benjamin, Vukojević, Katarina   +11 more
core   +1 more source

Genetic predisposition to porto‐sinusoidal vascular disorder: A functional genomic‐based, multigenerational family study

Hepatology, EarlyView., 2022
A deleterious variant of FCHSD1 results in mTOR pathway overactivation and may cause porto‐sinusoidal vascular disorder (PSVD). The pedigree of the family demonstrated an autosomal dominant disease with variable expressivity. Whole‐genome sequencing and Sanger sequencing both validated the existence of the FCHSD1 variant and the heterozygosity of c ...
Jingxuan Shan, André Megarbane, Aziz Chouchane, Deepak Karthik, Ramzi Temanni, Atilio Reyes Romero, Huiying Hua, Chun Pan, Xixi Chen, Murugan Subramanian, Chadi Saad, Hamdi Mbarek, Cybel Mehawej, Eliane Chouery, Sirin W. Abuaqel, Alexander Dömling, Sami Remadi, Cesar Yaghi, Pu Li, Lotfi Chouchane   +19 more
wiley   +1 more source

Case Report: A New Subtype of Lynch Syndrome Associated With MSH2 c.1024_1026 Identified in a Chinese Family

Frontiers in Medicine, 2022
BackgroundLynch syndrome is an autosomal dominant disorder associated with a high incidence of various cancer types. Multiple variants of mismatch repair genes have been reported for Lynch syndrome. However, the diagnosis in patients with atypical cancer
Lu Li, Zhe Zhao, Zhe Zhao, Lin Dong, Jia Jia, Ke Su, Hua Bai, Jie Wang   +7 more
doaj   +1 more source

Nrf2 overexpression increases risk of high tumor mutation burden in acute myeloid leukemia by inhibiting MSH2

Cell Death and Disease, 2021
Nuclear factor erythroid 2-related factor 2 (Nrf2, also called NFE2L2) plays an important role in cancer chemoresistance. However, little is known about the role of Nrf2 in tumor mutation burden and the effect of Nrf2 in modulating DNA mismatch repair ...
Ping Liu, Dan Ma, Ping Wang, Chengyun Pan, Qin Fang, Jishi Wang   +5 more
doaj   +1 more source

Single-nucleotide polymorphism profiling by multimodal-targeted next-generation sequencing in methotrexate-resistant and -sensitive human osteosarcoma cell lines

Frontiers in Pharmacology, 2023
Introduction: Methotrexate (MTX) is one of the most important drugs included in the first-line protocols to treat high-grade osteosarcoma (HGOS). Although several polymorphisms have been reported to be associated with drug response or MTX-related ...
Chiara Casotti, Chiara Casotti, Claudia Maria Hattinger, Maria Pia Patrizio, Silvia Luppi, Leonardo Fantoni, Leonardo Fantoni, Michela Pasello, Katia Scotlandi, Toni Ibrahim, Massimo Serra   +10 more
doaj   +1 more source

MSH2 (human mutS homolog 2) [PDF]

, 2005
Review on MSH2 (human mutS homolog 2), with data on DNA, on the protein encoded, and where the gene is ...
Domingo, E, Schwartz, S Jr, S Jr Schwartz, E Domingo   +3 more
core   +1 more source

MicroRNA-21 induces resistance to 5-fluorouracil by down-regulating human DNA MutS homolog 2 (hMSH2) [PDF]

, 2010
The overexpression of microRNA-21 (miR-21) is linked to a number of human tumors including colorectal cancer, where it appears to regulate the expression of tumor suppressor genes including p21, phosphatase and tensin homolog, TGFβ receptor II, and B ...
F. Lovat, Lovat, Francesca, Carlo M. Croce, Dino Amadori, Fishel, Richard, Francesca Lovat, Pierluigi Gasparini, Nicola Valeri, Muller Fabbri, C. M. Croce, Nuovo, Gerard J., D. Amadori, Valeri, Nicola, C. Braconi, Tushar Patel, Croce, Carlo M., T. Patel, PAONE, ALESSIO, Richard Fishel, K. M. Sumani, N. Valeri, M. Fabbri, Fabbri, Muller, G. J. Nuovo, Alessio Paone, Gasparini, Pierluigi, Sumani, Khela M., Amadori, Dino, Braconi, Chiara, Gerard J. Nuovo, Hansjuerg Alder, P. Gasparini, Khlea M. Sumani, Patel, Tushar, H. Alder, Chiara Braconi, Alder, Hansjuerg, R. Fishel   +37 more
core   +1 more source