Results 21 to 30 of about 5,812 (165)

Molecular Basis of Mismatch Repair Protein Deficiency in Tumors from Lynch Suspected Cases with Negative Germline Test Results [PDF]

, 2020
Some 10–50% of Lynch-suspected cases with abnormal immunohistochemical (IHC) staining remain without any identifiable germline mutation of DNA mismatch repair (MMR) genes.
Eldfors, Samuli, Jukka-Pekka Mecklin, Nieminen, Taina Tuulikki, Olkinuora, Alisa, Henrikki Almusa, Samuli Eldfors, Mecklin, Jukka-Pekka, Almusa, Henrikki, Taina Tuulikki Nieminen, Lepistö, Anna, Anna Lepistö, Peltomäki, Päivi, Alisa Olkinuora, Gylling, Annette, Annette Gylling, Päivi Peltomäki   +15 more
core   +1 more source

Low expression of MSH2 DNA repair protein is associated with poor prognosis in head and neck squamous cell carcinoma

Journal of Applied Oral Science, 2013
OBJECTIVE: This study aimed to investigate the expression of the MSH2 DNA repair protein in head and neck squamous cell carcinoma (HNSCC) in order to analyze its association with clinicopathologic factors and overall survival of patients.
Camila Santos Pereira, Marcos Vinicius Macedo de Oliveira, Lucas Oliveira Barros, Gabriela Alencar Bandeira, Sergio Henrique Sousa Santos, John R. Basile, Andre Luiz Sena Guimaraes, Alfredo Mauricio Batista De Paula   +7 more
doaj   +1 more source

Histone Deacetylase 10 Regulates DNA Mismatch Repair and May Involve the Deacetylation of MutS Homolog 2 [PDF]

, 2015
Background: The DNA mismatch repair protein MutS homolog 2 (MSH2) is an acetylated protein. Results: Histone deacetylase 10 (HDAC10) interacts with MSH2 and deacetylates MSH2 at Lys-73, which might stimulate MSH2 activity. Conclusion: HDAC10 promotes DNA
Yuan, Fenghua, Yuan, Zhigang, Radhakrishnan, Rangasudhagar, Seto, Edward, Telles, Elphine, Lane, William S, Xiang, Shengyan, Fang, Jia, Zhang, Xiaohong, Coppola, Domenico, Shibata, David, Li, Yixuan, Zhang, Yanbin   +12 more
core   +1 more source

Overexpression of MutL homolog 1 and MutS homolog 2 proteins have reversed prognostic implications for stage I–II colon cancer patients

Biomedical Journal, 2017
The outcome of colon cancer patients without lymph node metastasis is heterogeneous. Searching for new prognostic markers is warranted.One hundred twenty stage I-II colon cancer patients who received complete surgical excision during 1995-2004 were selected for this biomarker study.
Shih-Chiang Huang, Shiu-Feng Huang, Ya-Ting Chen, Yu Chang, Yu-Ting Chiu, Il-Chi Chang, Hong-Dar Isaac Wu, Jinn-Shiun Chen   +7 more
openaire   +3 more sources

Comparison of screening strategies for Lynch syndrome in patients with newly diagnosed endometrial cancer: a prospective cohort study in China

Cancer Communications, 2019
Background The prevalence of Lynch syndrome and screening strategies for this disorder in Chinese patients with endometrial cancer have seldom been investigated.
Xiaopei Chao, Lei Li, Ming Wu, Shuiqing Ma, Xianjie Tan, Sen Zhong, Yalan Bi, Jinghe Lang   +7 more
doaj   +1 more source

Pembrolizumab as a monotherapy or in combination with platinum-based chemotherapy in advanced non-small cell lung cancer with PD-L1 tumor proportion score (TPS) ≥50%: real-world data

OncoImmunology, 2021
Both pembrolizumab (P) and combination of pembrolizumab with platinum-based chemotherapy (PCT) represent standard 1st-line options for advanced non-small cell lung cancer (aNSCLC) with PD-L1 tumor proportion score (TPS) ≥50%.
Elizabeth Dudnik, Mor Moskovitz, Yakir Rottenberg, Anastasiya Lobachov, Rinat Mandelboim, Tzippy Shochat, Damien Urban, Mira Wollner, Hovav Nechushtan, Ofer Rotem, Alona Zer, Sameh Daher, Jair Bar, On behalf of the Israel Lung Cancer Group   +13 more
doaj   +1 more source

Immunophenotypic Evaluation of Mismatch Repair Proteins in Various Solid Tumours: A Cross-sectional Study from a Tertiary Care Cancer Centre in Rajasthan, India [PDF]

Journal of Clinical and Diagnostic Research
Introduction: Mismatch Repair (MMR) proteins are essential in correcting DeoxyRibo Nucleic Acid (DNA) replication errors, including point mutations, to maintain genetic stability.
Neha Sethi, Maneesh K Vijay, Shikha Goyal, Kusha Sharma, Praveena Vyas, Shweta Bansal, Haraina Kiran, Abha Mathur   +7 more
doaj   +1 more source

Analysis of the expression level and methylation of tumor protein p53, phosphatase and tensin homolog and mutS homolog 2 in N-methyl-N-nitrosourea-induced thymic lymphoma in C57BL/6 mice

Oncology Letters, 2017
Tumorigenesis is often caused by somatic mutation or epigenetic changes in genes that regulate aspects of cell death, proliferation and survival. Although the functions of multiple tumor suppressor genes have been well studied in isolation, how these genes cooperate during the progression of a single tumor remains unclear in numerous cases. The present
Xueyun, Huo, Zhenkun, Li, Shuangyue, Zhang, Changlong, Li, Meng, Guo, Jing, Lu, Jianyi, Lv, Xiaoyan, Du, Zhenwen, Chen   +8 more
openaire   +3 more sources

The Genomics of colorectal cancer: State of the art [PDF]

, 2008
The concept of the adenoma-carcinoma sequence, as first espoused by Morson et al. whereby the development of colorectal cancer is dependent on a stepwise progression from adenomatous polyp to carcinoma is well documented.
Hodgson, SV, Hodgson, Shirley V, Beggs, AD, Beggs, Andrew D; id_orcid   +3 more
core   +1 more source

Monosodium glutamate-induced alterations in MMR protein expression: A potential mechanism linking diet and colorectal cancer

Gastroenterology & Endoscopy
Background: Defective mismatch repair (MMR) proteins activate the microsatellite instability (MSI) pathway, contributing to colon carcinogenesis. Monosodium glutamate (MSG), a widely used flavor enhancer, has been implicated in colorectal cancer (CRC ...
Meenakshi Sundari Rajendran, Rajkumar Prabhakaran, Padma Malini Ravi   +2 more
doaj   +1 more source