Results 21 to 30 of about 10,290 (158)

Low expression of MSH2 DNA repair protein is associated with poor prognosis in head and neck squamous cell carcinoma

Journal of Applied Oral Science, 2013
OBJECTIVE: This study aimed to investigate the expression of the MSH2 DNA repair protein in head and neck squamous cell carcinoma (HNSCC) in order to analyze its association with clinicopathologic factors and overall survival of patients.
Camila Santos Pereira, Marcos Vinicius Macedo de Oliveira, Lucas Oliveira Barros, Gabriela Alencar Bandeira, Sergio Henrique Sousa Santos, John R. Basile, Andre Luiz Sena Guimaraes, Alfredo Mauricio Batista De Paula   +7 more
doaj   +1 more source

Comparison of screening strategies for Lynch syndrome in patients with newly diagnosed endometrial cancer: a prospective cohort study in China

Cancer Communications, 2019
Background The prevalence of Lynch syndrome and screening strategies for this disorder in Chinese patients with endometrial cancer have seldom been investigated.
Xiaopei Chao, Lei Li, Ming Wu, Shuiqing Ma, Xianjie Tan, Sen Zhong, Yalan Bi, Jinghe Lang   +7 more
doaj   +1 more source

Pembrolizumab as a monotherapy or in combination with platinum-based chemotherapy in advanced non-small cell lung cancer with PD-L1 tumor proportion score (TPS) ≥50%: real-world data

OncoImmunology, 2021
Both pembrolizumab (P) and combination of pembrolizumab with platinum-based chemotherapy (PCT) represent standard 1st-line options for advanced non-small cell lung cancer (aNSCLC) with PD-L1 tumor proportion score (TPS) ≥50%.
Elizabeth Dudnik, Mor Moskovitz, Yakir Rottenberg, Anastasiya Lobachov, Rinat Mandelboim, Tzippy Shochat, Damien Urban, Mira Wollner, Hovav Nechushtan, Ofer Rotem, Alona Zer, Sameh Daher, Jair Bar, On behalf of the Israel Lung Cancer Group   +13 more
doaj   +1 more source

MutY-Homolog (MYH) inhibition reduces pancreatic cancer cell growth and increases chemosensitivity [PDF]

, 2016
Patients with pancreatic ductal adenocarcinoma (PC) have a poor prognosis due to metastases and chemoresistance. PC is characterized by extensive fibrosis, which creates a hypoxic microenvironment, and leads to increased chemoresistance and intracellular
Biankin, Andrew, Goldstein, David, Johns, Amber, Mawson, Amanda, McCarroll, Joshua, Nunez, Andrea, Phillips, Phoebe, Sharbeen, George, Youkhana, Janet   +8 more
core   +1 more source

Mlh2 is an accessory factor for DNA mismatch repair in Saccharomyces cerevisiae. [PDF]

, 2014
In Saccharomyces cerevisiae, the essential mismatch repair (MMR) endonuclease Mlh1-Pms1 forms foci promoted by Msh2-Msh6 or Msh2-Msh3 in response to mispaired bases. Here we analyzed the Mlh1-Mlh2 complex, whose role in MMR has been unclear.
Bowen, Nikki, Campbell, Christopher S, Desai, Arshad, Gries, Kerstin, Hombauer, Hans, Kolodner, Richard D, Putnam, Christopher D, Srivatsan, Anjana   +7 more
core   +6 more sources

Immunophenotypic Evaluation of Mismatch Repair Proteins in Various Solid Tumours: A Cross-sectional Study from a Tertiary Care Cancer Centre in Rajasthan, India [PDF]

Journal of Clinical and Diagnostic Research
Introduction: Mismatch Repair (MMR) proteins are essential in correcting DeoxyRibo Nucleic Acid (DNA) replication errors, including point mutations, to maintain genetic stability.
Neha Sethi, Maneesh K Vijay, Shikha Goyal, Kusha Sharma, Praveena Vyas, Shweta Bansal, Haraina Kiran, Abha Mathur   +7 more
doaj   +1 more source

Exploring nucleo-cytoplasmic large DNA viruses in Tara Oceans microbial metagenomes [PDF]

, 2013
Nucleo-cytoplasmic large DNA viruses (NCLDVs) constitute a group of eukaryotic viruses that can have crucial ecological roles in the sea by accelerating the turnover of their unicellular hosts or by causing diseases in animals. To better characterize the
Acinas, Silvia G., Bork, Peer, Claverie, Jean-Michel, Clerissi, Camille, de Vargas, Colomban, Department of Applied Biological Sciences (DBIT), Vrije Universiteit Brussel, Brussels, Belgium, Department of Applied Biological Sciences (DBIT), Vrije Universiteit Brussel, Brussels, Belgium, Department of Applied Biological Sciences (DBIT), Vrije Universiteit Brussel, Brussels, Belgium, Desdevises, Yves, Faust, Karoline, Ferrera, Isabel, Grimsley, Nigel, Hingamp, Pascal, Jaillon, Olivier, Kandels-Lewis, Stefanie, Karsenti, Eric, Lima-Medez, Gipsi, Moreau, Hervé, Not, Fabrice, Ogata, Hiroyuki, Pesant, Stéphane, Poulain, Julie, Raes, Jeroen, Sarmento, Hugo, Subirana, Lucie, Sunagawa, Shinichi, Villar, Emilie, Wincker, Patrick   +27 more
core   +1 more source

DNA Checkpoint and Repair Factors Are Nuclear Sensors for Intracellular Organelle Stresses-Inflammations and Cancers Can Have High Genomic Risks. [PDF]

, 2018
Under inflammatory conditions, inflammatory cells release reactive oxygen species (ROS) and reactive nitrogen species (RNS) which cause DNA damage. If not appropriately repaired, DNA damage leads to gene mutations and genomic instability.
Chen, Hongping, Choi, Eric T., Cueto, Ramon, Drosatos, Konstantinos, Fu, Hangfei, Nanayakkara, Gayani K, Park, Joon Y., Qin, Xuebin, Shao, Lijian, Shao, Ying, Sheng, Haitao, Sun, Jianxin, Sun, Yu, Wang, Hong, Wang, Luqiao, Wu, Na, Yang, Qian, Yang, William Y, Yang, Wuping, Yang, Xiaofeng, Zeng, Huihong, Zhu, Qingxian   +21 more
core   +2 more sources

Pms2 suppresses large expansions of the (GAA·TTC)n sequence in neuronal tissues [PDF]

, 2012
Copyright @ 2012 Bourn et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source ...
Chiranjeevi Sandi, David T. Kirkpatrick, Irene De Biase, Mark A. Pook, Rebecka L. Bourn, Ricardo Mouro Pinto, Sahar Al-Mahdawi, Sanjay I. Bidichandani   +7 more
core   +5 more sources

Meiosis genes in and the role of parthenogenesis in genome evolution [PDF]

, 2009
Background Thousands of parthenogenetic animal species have been described and cytogenetic manifestations of this reproductive mode are well known. However, little is understood about the molecular determinants of parthenogenesis.
Andrew M Schurko, John M Logsdon, Brian D Eads, GN Stone, M Lynch, J Mallet, M Morgan-Richards, MF Dybdahl, C Wallace, PM Ferree, MG Riparbelli, E Suomalainen, TA Gorr, N Tatarazako, PD Hebert, F Zaffagnini, H Lumer, F Zaffagnini, AR Omilian, JK Colbourne, S Paland, M Lynch, PE Cohen, K Nasmyth, JL Gerton, S Hauf, M Petronczki, Y Watanabe, J Brennecke, AA Aravin, C Klattenhoff, T Kishimoto, AL Marston, JZ Morris, M Fu, Y Geng, S Ortega, M Malumbres, M Kasten, O Cohen-Fix, K Nasmyth, V Guacci, SP Bell, SL Forsburg, D Maiorano, HL Blanton, M Lutzmann, JW Barnes, AL Gotter, RC Chan, AL Gotter, JA Cobb, L Wu, RM Brosh Jr, ID Hickson, JL Plank, B Rockmill, PB Moens, DN Cox, K Nonomura, MA Ramesh, S Gruber, TS Kitajima, SE Thomas, L Strom, E Unal, I Sumara, A Losada, VL Katis, TS Kitajima, DQ Ding, G De Piccoli, J Torres-Rosell, A Losada, T Hirano, N Cobbe, E Revenkova, N Pezzi, A Bergerat, S Keeney, SB Malik, DK Bishop, A Shinohara, JY Masson, A Shinohara, DK Bishop, M Tarsounas, GV Petukhova, RJ Pezza, G Petukhova, M Shinohara, N Sarai, J Wesoly, GV Petukhova, C Zierhut, NY Stassen, Z Lin, J Jiricny, T Snowden, S Neyton, Z Lin, KM Culligan, TF Wang, M Raschle, GM Li, SM Baker, SM Lipkin, S Santucci-Darmanin, E Cannavo, PC Chen, P Pasierbek, S Yokobayashi, R Chenna, DR Maddison, F Ronquist, S Whelan   +115 more
core   +1 more source