Results 71 to 80 of about 2,071,822 (293)
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
Constructing a Digital Storycircle: Digital Infrastructure and Mutual Recognition [PDF]
, 2014 Building on the principles of the digital storytelling movement, this article asks whether the narrative exchange within the ‘storycircles’ of storymakers created in face-to-face workshops can be further replicated by drawing on digital infrastructure in
MacDonald, R.L. +20 more
core +1 more source
USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival
Molecular Oncology, EarlyView.CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna +8 more
wiley +1 more source
Il principio del mutuo riconoscimento nell'ordinamento dell'Unione europea [PDF]
, 2020 The essay analyses the principle of mutual recognition as a legal technique of coordination of the Member States’ legal systems. We examine its ability of ensuring effectiveness of the individual’s fundamental rights and of favouring the European ...
Giorgi, Eloisa
core +1 more source
Transatlantic Integration and Developed Countries Competitiveness Problems
Vestnik MGIMO-Universiteta, 2016 Factors and possible consequences of transatlantic integration are elaborated in the article. An overview of the history of transatlantic cooperation is provided. The author highlights the paramount goal of Transatlantic Trade and Investment Partnership (
Alexey. A. Sidorov
doaj +3 more sources
The Interplay Between the European Investigation Order and the Principle of Mutual Recognition
European Papers(Series Information) European Papers - A Journal on Law and Integration, 2023 8(3), 1575-1597 | Article | (Table of Contents) I. Introduction. – II. New formulas in the regime of mutual recognition in the EIO. – III.
István Szijártó
doaj +1 more source
Molecular Oncology, EarlyView.Enterotoxigenic Bacteroides fragilis is a gut bacterium linked to bowel cancer. We propose that its toxin acts along two routes: at the cell surface, cutting the adhesion protein E‐cadherin and triggering inflammation; and inside the cell, delivered by bacterial vesicles, switching on NOD1 and cancer stem cell programs.
Kangchan Choi +2 more
wiley +1 more source
European Papers(Series Information) European Papers - A Journal on Law and Integration, 2025 10(1), 45-53 | Article | (Table of Contents) 1. Introduction. – 2. No uniform refugee status and no automatic recognition of positive decisions. – 3.
Vladislava Stoyanova
doaj +1 more source
“Inter-administrative Tie” of Administrative Acts in the European Union Law [PDF]
Societas et Iurisprudentia, 2017 The presented paper deals with specific phenomenon of the “inter-administrative tie” which some of the norms of the European Union law award to administrative acts issued by national administrative authorities. This “inter-administrative tie” implies the
Jakub Handrlica
doaj
FEBS Open Bio, EarlyView.The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley +1 more source