Results 71 to 80 of about 2,323 (154)

Abstracts

Molecular Oncology, Volume 20, Issue S1, Page 1-692, August 2026.
Abstracts submitted to the ‘EACR 2026 Congress: Innovative Cancer Science’, from 08–11 June 2026 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
wiley   +1 more source

Identification of a Germline XAF1 Mutation in Patients With Gastrointestinal Cancers

Human Mutation, Volume 2026, Issue 1, 2026.
Background Gastrointestinal (GI) cancers can be attributed to the interplay between genetic and environmental factors. To date, apart from certain cancer syndromes, the genetic factors underlying familial GI cancers have not been clearly elucidated.
Guan-Xin Xu, Hang Zhang, Chang-Xing Wang, Ying-Zhi Zhang, Ping-Ping Lv, Chun Feng, Yao Ning, Miao Shen, Sai Zhang, Min Jin, Dan-Qing Yu, Hannah Wesley   +11 more
wiley   +1 more source

Simplifying the detection of MUTYH mutations by high resolution melting analysis

BMC Cancer, 2010
Background MUTYH-associated polyposis (MAP) is a disorder caused by bi-allelic germline MUTYH mutation, characterized by multiple colorectal adenomas. In order to identify mutations in MUTYH gene we applied High Resolution Melting (HRM) genotyping.
López-Villar Isabel, Ayala Rosa, Wesselink Jan, Morillas Juan, López Elena, Marín José, Díaz-Tasende José, González Sara, Robles Luis, Martínez-López Joaquín   +9 more
doaj   +1 more source

Colorectal carcinomas in MUTYH-associated polyposis display histopathological similarities to microsatellite unstable carcinomas

BMC Cancer, 2009
Background MUTYH-associated polyposis (MAP) is a recessively inherited disorder which predisposes biallelic carriers for a high risk of polyposis and colorectal carcinoma (CRC).
Tops Carli MJ, van Eijk Ronald, van Wezel Tom, Middeldorp Anneke, Jordanova Ekaterina S, van Puijenbroek Marjo, de Miranda Noel FCC, Nielsen Maartje, Vasen Hans FA, Hes Frederik J, Morreau Hans   +10 more
doaj   +1 more source

Novel mutations and phenotypic associations identified through APC, MUTYH, NTHL1, POLD1, POLE gene analysis in Indian Familial Adenomatous Polyposis cohort

Scientific Reports, 2017
Colo-Rectal Cancer is a common cancer worldwide with 5–10% cases being hereditary. Familial Adenomatous Polyposis (FAP) syndrome is due to germline mutations in the APC or rarely MUTYH gene.
Nikhat Khan, Anuja Lipsa, Gautham Arunachal, Mukta Ramadwar, Rajiv Sarin   +4 more
doaj   +1 more source

Rectum-Sparing Surgery May be Appropriate for Biallelic MutYH-Associated Polyposis

Diseases of the Colon & Rectum, 2010
The risk of cancer or severe polyposis of the rectal stump after total colectomy for MutYH-associated polyposis is scarcely defined. To evaluate this risk, we describe the findings of endoscopic surveillance of the rectal stump in a series of patients with biallelic MutYH mutations and polyposis.This is a retrospective, observational, multicenter case ...
NASCIMBENI R, PUCCIARELLI, SALVATORE, DI LORENZO D, URSO E, CASELLA C, AGOSTINI, MARCO, NITTI, DONATO, SALERNI B.   +7 more
openaire   +3 more sources

MUTYH-associated polyposis: Is it time to change upper gastrointestinal surveillance? A single-center case series and a literature overview. [PDF]

World J Gastrointest Oncol, 2023
Sanchez-Mete L, Mosciatti L, Casadio M, Vittori L, Martayan A, Stigliano V.   +5 more
europepmc   +1 more source

Assessing the pathogenicity of a variant of uncertain significance in the ALK gene in right-sided colon polyposis

Cancer Treatment and Research Communications
Colorectal cancer (CRC) is the third most common cancer worldwide. Generally, Familial Adenomatous Polyposis (FAP) accounts for about 1 % to 2 % of all colorectal cancer cases.
Zeinab Aliyari Serej, Maryam Naghinejad, Sepideh Parvizpour, Mortaza Raeisi, Vahid Jafarlou, Abbas Ebrahimi Kalan, Sima Mansoori Derakhshan, Mohammad Taheri   +7 more
doaj   +1 more source

MUTYH-Associated Polyposis [PDF]

, 2020
openaire   +2 more sources

Monogenic predisposition to colorectal cancer: features of carcinogenesis and translational aspects

Сибирский онкологический журнал
Objective: to summarize existing information on hereditary types of colorectal cancer.Material and Methods. A literature search was conducted in the Medline, Cochrane Library, and Elibrary databases, including publications from January 2002 to October ...
G. A. Yanus, A. G. Iyevleva, A. Yu. Malygin, E. N. Suspitsin, S. N. Aleksakhina, E. N. Imyanitov   +5 more
doaj   +1 more source