Results 61 to 70 of about 6,242 (173)
Structural Basis for Nucleobase Activation by the Adenine DNA Glycosylase MutY
ChemBioChem, Volume 27, Issue 11, 15 June 2026.DNA glycosylase MutY engages its adenine nucleobase substrate in a syn orientation with a catalytic Glu. X‐ray crystal structures of MutY with Glu replaced suggest that a disengaged “on hold” state with anti nucleobase orientation may explain how MutY avoids catastrophic activity at inappropriate adenines.
L. Peyton Russelburg +4 more
wiley +1 more source
Journal of Experimental & Clinical Cancer Research, 2008 Background Genetic polymorphisms of DNA repair enzymes may lead to genetic instability and colorectal cancer carcinogenesis. Our objective was to measure the interactions between polymorphisms of repair genes and tobacco smoking in colorectal cancer ...
Tabuchi Yoshiki +11 more
doaj +1 more source
Oxidative Stress and DNA Epigenetic Modifications in Cancer: Mechanisms and Targeted Therapeutics
MedComm – Oncology, Volume 5, Issue 2, June 2026.Reactive oxygen species (ROS) modulate DNA methyltransferases (DNMTs), ten‐eleven translocation family proteins (TETs) and their cofactors, reshaping 5‐methylcytosine (5mC)/5‐hydroxymethylcytosine (5hmC)/5‐formylcytosine (5fC) landscapes and gene expression in cancer cells. In turn, epigenetic control of antioxidant and metabolic pathways feeds back on
Xishan Yang +7 more
wiley +1 more source
MedComm – Oncology, Volume 5, Issue 2, June 2026.This article systematically elucidates the molecular mechanisms of colorectal precancerous lesions, introduces cutting‐edge research tools like multi‐omics and organoids, and highlights the potential and prospects of natural products such as berberine, resveratrol, and curcumin in preventing and intervening in colorectal carcinogenesis by modulating ...
Shunji Liu +6 more
wiley +1 more source
The significance of MUTYH c.892-2A>G splicing mutation in familial breast cancer
Zhongguo aizheng zazhi, 2017 Background and purpose: It is suggested that MUTYH mutation is closed to high colorectal cancer risk, but it is not clear that the relationship between MUTYH mutation and susceptibility to familiar breast carcinoma.
简文静, 邵 康, 肖 瑜
doaj
Intussusception reveals MUTYH-associated polyposis syndrome and colorectal cancer: a case report
BMC Cancer, 2019 Background We are reporting a rare case of MUTYH-associated polyposis, a colorectal cancer hereditary syndrome, diagnosticated after an intussusception.
Gustavo Heluani Antunes de Mesquita +11 more
doaj +1 more source
Oxidative Stress in the Tumor Immune Microenvironment: Mechanisms and Therapeutic Perspectives
MedComm – Oncology, Volume 5, Issue 2, June 2026.Oxidative stress is involved in several key processes in cancer, including redox regulation, DNA damage, post‐translational modifications, transcriptional regulation, epigenetic modifications, metabolic reprogramming, cell death, and immune modulation. These mechanisms collectively influence tumor progression, immune evasion, and therapeutic responses,
Zhen Wang +14 more
wiley +1 more source
npj Precision OncologyThe MUTYH base excision repair protein corrects oxidative DNA damage. Bi-allelic germline MUTYH mutations cause a rare, Mendelian recessive syndrome of colorectal adenomas, duodenal polyps and colorectal cancer (CRC), in which tumours have excess somatic
Kitty Sherwood +10 more
doaj +1 more source
Cost-utility analysis of genetic screening in families of patients with germline
BMC Medical Genetics, 2007 Background MUTYH associated polyposis (MAP) is an autosomal recessive inherited disorder. Carriers of bi-allelic MUTYH germline mutations have a risk of approximately 60% to develop colorectal carcinoma (CRC).
Vasen Hans FA +3 more
doaj +1 more source
MUTYH-associated Polyposis [PDF]
Case Medical Research, 2000 M Nielsen, F Hes
openaire +2 more sources