Results 111 to 120 of about 35,534 (303)

Selective inhibition of the p53–MDM2 interaction by nutlin drugs: a new therapeutic perspective for neuroblastoma [PDF]

, 2013
Neuroblastoma is one of the most common and most deadly childhood tumors. There is an unmet need to develop new therapeutic modalities for this malignancy that preferentially should be guided by our increasing knowledge of the biology of neuroblastoma ...
De Paepe, Anne, Rihani, Ali, Speleman, Franki, Van Goethem, Alan, Van Maerken, Tom, Vandesompele, Jo   +5 more
core   +1 more source

DNA methylation profiling of primary neuroblastoma tumors using methyl-CpG-binding domain sequencing [PDF]

, 2016
Comprehensive genome-wide DNA methylation studies in neuroblastoma (NB), a childhood tumor that originates from precursor cells of the sympathetic nervous system, are scarce. Recently, we profiled the DNA methylome of 102 well-annotated primary NB tumors
Decock, Anneleen, Ongenaert, Maté, Speleman, Franki, Van Criekinge, Wim, Vandesompele, Jo   +4 more
core   +1 more source

Targeting GRP78 and the Proteostasis Network to Break the Therapeutic Ceiling in Neuroendocrine Prostate Cancer

iNew Medicine, EarlyView.
ABSTRACT HSPA5 (also known as GRP78/BiP) is a master regulator of the endoplasmic reticulum (ER) stress response and a key node in the proteostasis network. In neuroendocrine prostate cancer (NEPC), an aggressive, therapy‐refractory lineage that emerges under pressure from androgen receptor (AR) directed therapies, GRP78 is upregulated and co‐opted to ...
Amos Olalekan Akinyemi, Md Rakibul Alam, Mithu Howlader, Mohammad Esfini Farahani, Lixiang Gu, Chun Li, Chripus Ngule, Kevin Fulp, Bolaji Owoyemi, Xinyi Wang, Samuel Nwadialo, Fatemeh Selani, Makumba Esoe, Obaleye Oluwafunminiyi, Zhiguo Li   +14 more
wiley   +1 more source

The MYCN Oncogene [PDF]

, 2013
MYCN is a member of the MYC family of oncogenes, which also includes c-MYC and MYCL. Despite knowing about the existence of MYCN for nearly thirty years, the majority of functional studies involving MYC family members have focused on c-MYC due to the limited expression profile of MYCN in human cancers, and also in part due to the existence of highly ...
Cheung, Leanna, Murray, Jayne E., Haber, Michelle, Norris, Murray D.   +3 more
openaire   +2 more sources

Small Nucleotide Variant Analysis Using RNA Fusion Panel (SMURF): Making the Most of RNAseq Data in Solid Tumours

Journal of Clinical Laboratory Analysis, EarlyView.
RNA‐based fusion panels using targeted next‐generation sequencing of formalin‐fixed paraffin‐embedded (FFPE) tumour tissue specimens have been used for a few years from patients with various tumour types to detect rearrangements/fusions. Using the bioinformatic approaches the data obtained from RNA sequencing (RNAseq) can also be used for small ...
Pranav Dorwal, Julie Robin, Broden Krause, Patricia Pyrchla, Bin Yuan, Robert Quach, Anna Fong Na Goh, Pamela Htain, Noel Djitro, Amit Kumar, Liyan Song, Priscillia Siswara, Suzanne Svobodova, Peter Kaub, Beena Kumar   +14 more
wiley   +1 more source

Transcriptional regulation of genes by MYCN in PAX3::FOXO1-positive rhabdomyosarcomas and their roles in cell cycle progression

EJC Paediatric Oncology
Background: MYCN amplification and high expression is associated with pediatric malignancies including neuroblastoma and alveolar rhabdomyosarcoma. MYCN transcription in alveolar rhabdomyosarcomas is driven by a feedback loop with the PAX3::FOXO1 fusion ...
Zoë S. Walters, Daniel Leongamornlert, Barbara Villarejo-Balcells, Carmen Tse, Reuben Pengelly, Ian Titley, Janet Shipley   +6 more
doaj   +1 more source

Aryl hydrocarbon receptor downregulates MYCN expression and promotes cell differentiation of neuroblastoma.

PLoS ONE, 2014
Neuroblastoma (NB) is the most common malignant disease of infancy. MYCN amplification is a prognostic factor for NB and is a sign of highly malignant disease and poor patient prognosis. In this study, we aimed to investigate novel MYCN-related genes and
Pei-Yi Wu, Yung-Feng Liao, Hsueh-Fen Juan, Hsuan-Cheng Huang, Bo-Jeng Wang, Yen-Lin Lu, I-Shing Yu, Yu-Yin Shih, Yung-Ming Jeng, Wen-Ming Hsu, Hsinyu Lee   +10 more
doaj   +1 more source

MEIS2 Is an Adrenergic Core Regulatory Transcription Factor Involved in Early Initiation of TH-MYCN-Driven Neuroblastoma Formation

Cancers, 2021
Simple Summary Neuroblastoma is a pediatric tumor originating from the sympathetic nervous system responsible for 10–15% of all childhood cancer deaths.
J. De Wyn, Mark W. Zimmerman, Nina Weichert-Leahey, C. Nunes, B. Cheung, B. Abraham, A. Beckers, P. Volders, Bieke Decaesteker, Daniel R. Carter, A. Look, K. De Preter, Wouter Van Loocke, G. Marshall, A. Durbin, F. Speleman, K. Durinck   +16 more
semanticscholar   +1 more source

Interventional oncology in children: Where are we now?

Journal of Medical Imaging and Radiation Oncology, EarlyView.
Abstract Paediatric Interventional Oncology (IO) lags behind adult IO due to a scarcity of specific outcome data. The suboptimal way to evolve this field is relying heavily on adult experiences. The distinct tumour types prevalent in children, such as extracranial germ cell tumours, sarcomas, and neuroblastoma, differ strongly from those found in ...
Premal Amrishkumar Patel, Fernando Gómez Muñoz   +1 more
wiley   +1 more source

Accurate RT-qPCR gene expression analysis on cell culture lysates [PDF]

, 2012
Gene expression quantification on cultured cells using the reverse transcription quantitative polymerase chain reaction (RT-qPCR) typically involves an RNA purification step that limits sample processing throughput and precludes parallel analysis of ...
Mestdagh, Pieter, Van Peer, Gert, Vandesompele, Jo   +2 more
core   +2 more sources