Results 91 to 100 of about 763,886 (286)

X-Ray Amplification by Stimulated Brillouin Scattering [PDF]

Phys. Rev. E 96, 023209 (2017), 2017
Plasma-based parametric amplification using stimulated Brillouin scattering offers a route to coherent x-ray pulses orders-of-magnitude more intense than those of the brightest available sources. Brillouin amplification permits amplification of shorter wavelengths with lower pump intensities than Raman amplification, which Landau and collisional ...
arxiv   +1 more source

Aryl hydrocarbon receptor downregulates MYCN expression and promotes cell differentiation of neuroblastoma.

PLoS ONE, 2014
Neuroblastoma (NB) is the most common malignant disease of infancy. MYCN amplification is a prognostic factor for NB and is a sign of highly malignant disease and poor patient prognosis. In this study, we aimed to investigate novel MYCN-related genes and
Pei-Yi Wu, Yung-Feng Liao, Hsueh-Fen Juan, Hsuan-Cheng Huang, Bo-Jeng Wang, Yen-Lin Lu, I-Shing Yu, Yu-Yin Shih, Yung-Ming Jeng, Wen-Ming Hsu, Hsinyu Lee   +10 more
doaj   +1 more source

MYCN Amplification Is Associated with Repressed Cellular Immunity in Neuroblastoma: An In Silico Immunological Analysis of TARGET Database

Frontiers in Immunology, 2017
Purpose RNA and DNA sequencing data are traditionally used to discern intrinsic cellular pathways in cancer pathogenesis, their utility for investigating the tumor microenvironment (TME) has not been fully explored.
Peng Zhang, Xiaofang Wu, Moushumi Basu, Chen Dong, P. Zheng, Yang Liu, A. Sandler   +6 more
semanticscholar   +1 more source

Single‐Cell Atlas Reveals Tumorigenic Profiles and Immune Dynamics of Adrenal Incidentalomas

Advanced Science, EarlyView.
Single‐cell RNA sequencing reveals cellular heterogeneity in adrenal incidentalomas, identifying distinct tumor cell populations. Clusterin is recognized as a biomarker for adrenocortical tumors, correlating with established markers. MYCN‐positive clusters in pheochromocytomas indicated poorer survival.
Meng Wang, Guangmin Zheng, Xiaoyong Hu, Feng Tian, Tuo Li, Zheng Zhang, Kan Gong, Shiwei Chen, Lin Yuan, Yu Qi, Lin Li, Daofu Cheng, Liu Liu, Fuqiang Liu, Yujing Sun, Xiangdong Fang, Ruxing Zhao, Bing Liu, Chao Zhang   +18 more
wiley   +1 more source

Predicting Amplification of MYCN using CpG Methylation Biomarkers in Neuroblastoma

Future Oncology, 2021
Background: Neuroblastoma is the most common extracranial solid tumor in childhood. Amplification of MYCN in neuroblastoma is a predictor of poor prognosis. Materials and methods: DNA methylation data from the TARGET data matrix were stratified into MYCN amplified and non-amplified groups.
Abdulazeez Giwa, Sophia Catherine Rossouw, Azeez Fatai, Junaid Gamieldien, Alan Christoffels, Hocine Bendou   +5 more
openaire   +4 more sources

Evaluation of Norepinephrine Transporter Expression and Metaiodobenzylguanidine Avidity in Neuroblastoma: A Report from the Childrens Oncology Group. [PDF]

, 2012
Purpose. (123)I-metaiodobenzylguanidine (MIBG) is used for the diagnostic evaluation of neuroblastoma. We evaluated the relationship between norepinephrine transporter (NET) expression and clinical MIBG uptake. Methods. Quantitative reverse transcription
Attiyeh, Edward, Baker, David, Batra, Vandana, Dubois, Steven, Geier, Ethan, Giacomini, Kathleen, Hogarty, Michael, Kreissman, Susan, London, Wendy, Maris, John, Martinez, Daniel, Matthay, Katherine, Naranjo, Arlene, Neuhaus, John, Pawel, Bruce, Segal, Mark, Yanik, Greg, Yee, Sook   +17 more
core   +2 more sources

Dualism between Optical and Difference Parametric Amplification [PDF]

EPL 119, 24002 (2017), 2017
Breaking the symmetry in a coupled wave system can result in unusual amplification behavior. In the case of difference parametric amplification the resonant pump frequency is equal to the difference, instead of the sum, frequency of the normal modes.
arxiv   +1 more source

A prospective evaluation of liquid biopsy for detecting MYCN amplification in neuroblastoma patients.

Japanese Journal of Clinical Oncology, 2019
BACKGROUND Our previous study reported a method for determining MYCN gene amplification (MNA) status using cell-free DNA in serum. We prospectively analyzed the serum MNA status using sera obtained before the initial diagnosis from patients with ...
T. Iehara, S. Yagyu, T. Gotoh, Kazutaka Ouchi, Hideki Yoshida, M. Miyachi, K. Kikuchi, T. Sugimoto, H. Hosoi   +8 more
semanticscholar   +1 more source

Patient‐Derived Bladder Cancer Organoids as a Valuable Tool for Understanding Tumor Biology and Developing Personalized Treatment

Advanced Science, Volume 12, Issue 13, April 3, 2025.
We have established the first Asian‐based bladder cancer PDOs biobank, demonstrating their accuracy in mirroring parental tumors’ properties. Drug screening reveals diverse sensitivities to chemotherapies and targeted therapies, validated by PDO xenografts and patient outcomes. Genetic profiling identifies key genes associated with response to standard
Hongda Zhao, Na Lin, Vincy Wing Sze Ho, Kang Liu, Xuan Chen, Hongwei Wu, Peter Ka‐Fung Chiu, Linda Huang, Zahra Dantes, Ka‐Leung Wong, Ho‐Fai Chau, Ivan Ching‐Ho Ko, Chris Ho‐Ming Wong, David Ka‐Wai Leung, Steffi Kar‐Kei Yuen, Dinglan Wu, Xiaofan Ding, Chi Fai Ng, Jeremy Yuen‐Chun Teoh   +18 more
wiley   +1 more source

Multiple mechanisms disrupt the let-7 microRNA family in neuroblastoma [PDF]

, 2015
Poor prognosis in neuroblastoma is associated with genetic amplification of MYCN. MYCN is itself a target of let-7, a tumour suppressor family of microRNAs implicated in numerous cancers.
A Beckers, A Urbach, AD Bosson, AM Gurtan, Areum Han, B Boyerinas, BB Madison, BL Thériault, BP Lewis, C Mayr, C Mayr, C Melton, Catherine S. Spina, CJ Breen, CM Croce, CS Hackett, D Kim, D Rakheja, Daniel S. Pearson, DE Rushlow, DP Bartel, FA Karreth, Frank Berthold, Frederik Roels, G Barone, G Blandino, George Q. Daley, GM Brodeur, Grace S. LaPier, HC Tu, Ho-Chou Tu, HR Chiang, I Bray, J Lu, J Thiessen, James J. Collins, Jessica Theißen, Jihan K. Osborne, JJ Molenaar, JJ Molenaar, JM Maris, JM Maris, JM Maris, John T. Powers, K Ejeskär, Kaloyan M. Tsanov, KJ Baeyens, Kyle C. Kurek, L Poliseno, LH Nguyen, M Cesana, M Hafner, Marc Seligson, Marcella Cesana, NE Sanjana, O Shalem, Patrick Cahan, R Denzler, R Iwakawa, R Spitz, RC Seeger, Richard Ebright, S Iwasaki, S Roush, Samantha J. Ross, SJ Diskin, SM Johnson, SR Viswanathan, SR Viswanathan, TJ Pugh, TJ Pugh, U Ala, VB Sampson, WJ Kent, Y Tay, Yvanka de Soysa   +75 more
core   +2 more sources