Results 121 to 130 of about 763,886 (286)

Vascular encasement image defined risk factors independently predict surgical complications in neuroblastoma

ANZ Journal of Surgery, EarlyView.
This single centre retrospective study supports a correlation between vascular encasement image defined risk factors post neoadjuvant chemotherapy and surgical complications, in patients with neuroblastoma. Reporting IDRF subtypes may facilitate surgical planning and minimize post‐operative complications. Abstract Background Specific image defined risk
Rachael Stokes, Aidan Bannon, Bonnie Leung, Jasmin Alloo, David Davies‐Payne, Mark Winstanley, Andrew Wood, Stephen Evans, James Hamill   +8 more
wiley   +1 more source

Influence of neuroblastoma stage on serum‐based detection of MYCN amplification [PDF]

Pediatric Blood & Cancer, 2009
AbstractBackgroundMYCN oncogene amplification has been defined as the most important prognostic factor for neuroblastoma (NB), the most common solid extracranial neoplasm in children. High copy numbers are strongly associated with rapid tumor progression and poor outcome, independently of tumor stage or patient age, and this has become an important ...
Alain Puisieux, Alain Puisieux, Michael D. Hogarty, Stéphanie Bréjon, Raphael Rousseau, Raphael Rousseau, Nicole Gross, Valérie Combaret, Patrick McGrady, Rosa Noguera, Wendy B. London, Isabelle Iacono, Katrien Swerts   +12 more
openaire   +4 more sources

Resource availability for CNS tumor diagnostics in the Asian Oceanian region: A survey by the Asian Oceanian Society of Neuropathology committee for Adapting Diagnostic Approaches for Practical Taxonomy in Resource‐Restrained Regions (AOSNP‐ADAPTR)

Brain Pathology, EarlyView.
Asian Oceanian Society of Neuropathology‐Adapting Diagnostic Approaches for Practical Taxonomy in Resource‐Restrained Regions survey provides an overview of in‐house/ local and outsourcing resources in Asian Oceanian region for brain tumor diagnostics according to World Health Organization classification of Central Nervous System tumors.
Chitra Sarkar, Shilpa Rao, Vani Santosh, Maysa Al‐Hussaini, Sung Hye Park, Tarik Tihan, Michael E. Buckland, Ho‐Keung Ng, Takashi Komori   +8 more
wiley   +1 more source

MYCC and MYCN Oncogene Amplification in Medulloblastoma [PDF]

Archives of Pathology & Laboratory Medicine, 2002
Abstract Context.—Brain tumors are the most common solid tumor in childhood, and medulloblastoma is the most common malignant brain tumor in this age group. Cytogenetic abnormalities that have been described in childhood medulloblastoma include loss of 17p, amplification of MYCC (c-myc), amplification of MYCN (N-myc), and isochromosome ...
Sandra H. Bigner, Laurence E. Becker, Naji Aldosari, Henry S. Friedman, Peter C. Burger, Roger E. McLendon, James L. Kepner   +6 more
openaire   +1 more source

Loss of a FYN-regulated differentiation and growth arrest pathway in advanced stage neuroblastoma [PDF]

, 2002
Tumor stage, age of patient, and amplification of MYCN predict disease outcome in neuroblastoma. To gain insight into the underlying molecular pathways, we have obtained expression profiles from 94 primary neuroblastoma specimens.
Bergmann, Eckhard, Bernard, Sandra, Berwanger, Bernd, Christiansen, Holger, Eilers, Martin, Flynn, Daniel, Hartmann, Oliver, Kartal, Ali, Krause, Michael, Nielsen, Dirk, Schwab, Manfred, Schäfer, Helmut, Wiedemeyer, Ruprecht   +12 more
core   +1 more source

A Quantitative Analysis of Localized Robustness of MYCN in Neuroblastoma [PDF]

arXiv, 2015
The amplification of the gene MYCN (V-myc myelocytomatosis viral-valeted oncogene, neuroblastoma derived) has been a well-documented indicator for poor prognosis in neuroblastoma, a childhood cancer. Unfortunately, there has been limited success in understanding MYCN functionality in the landscape of neuroblastoma and more importantly, given that MYCN ...
arxiv  

Validation of target‐enriched enzymatic methylation sequencing for brain tumor classification from formalin‐fixed paraffin embedded‐derived DNA

Brain Pathology, EarlyView.
Target‐enriched enzymatic methylation sequencing (TEEM‐seq), a DNA methylation sequencing method using the Twist Human Methylome panel, shows comparable performance to array‐based tumor methylation profiling. The method is compatible with both frozen and formalin‐fixed paraffin‐embedded (FFPE) samples and is a viable approach to tumor methylation and ...
Quynh T. Tran, Sujuan Jia, Md. Zahangir Alom, Lu Wang, Charles G. Mullighan, Ruth G. Tatevossian, Brent A. Orr   +6 more
wiley   +1 more source

CDK7 Inhibition Suppresses Super-Enhancer-Linked Oncogenic Transcription in MYCN-Driven Cancer [PDF]

, 2014
The MYC oncoproteins are thought to stimulate tumor cell growth and proliferation through amplification of gene transcription, a mechanism that has thwarted most efforts to inhibit MYC function as potential cancer therapy.
Abraham, Brian Joseph, Altabef, Abigail, Chipumuro, Edmond, Christensen, Camilla L., George, Rani E., Gray, Nathanael S., Hatheway, Clark M., Kwiatkowski, Nick, Marco, Eugenio, Perez-Atayde, Antonio, Sharma, Bandana, Wong, Kwok-Kin, Yeung, Caleb, Young, Richard A, Yuan, Guo-Cheng, Zhang, Tinghu   +15 more
core   +1 more source

Lack of correlation between MYCN expression and the Warburg effect in neuroblastoma cell lines

BMC Cancer, 2008
Background Many cancers preferentially meet their energy requirements through the glycolytic pathway rather than via the more efficient oxidative phosphorylation pathway. It is thought that this is an important adaptation in cancer malignancy.
Hatzinisiriou Irene, Cossins Luke R, Smith Danielle J, Haber Michelle, Nagley Phillip   +4 more
doaj   +1 more source

Influence of segmental chromosome abnormalities on survival in children over the age of 12 months with unresectable localised peripheral neuroblastic tumours without MYCN amplification

British Journal of Cancer, 2014
Background:The prognostic impact of segmental chromosome alterations (SCAs) in children older than 1 year, diagnosed with localised unresectable neuroblastoma (NB) without MYCN amplification enrolled in the European Unresectable Neuroblastoma (EUNB ...
R. Defferrari, K. Mazzocco, I. Ambros, P. Ambros, Clare Bedwell, K. Beiske, J. Bénard, Ana P. Berbegall, N. Bown, V. Combaret, J. Couturier, Giovanni Erminio, C. Gambini, A. Garaventa, N. Gross, R. Haupt, J. Kohler, M. Jeison, J. Lunec, B. Marques, T. Martinsson, R. Noguera, S. Parodi, G. Schleiermacher, G. Schleiermacher, D. Tweddle, A. Valent, N. Roy, A. Vícha, E. Villamón, G. Tonini   +30 more
semanticscholar   +1 more source