Results 141 to 150 of about 763,886 (286)

Sunitinib suppress neuroblastoma growth through degradation of MYCN and inhibition of angiogenesis.

PLoS ONE, 2014
Neuroblastoma, a tumor of the peripheral sympathetic nervous system, is the most common and deadly extracranial tumor of childhood. The majority of high-risk neuroblastoma exhibit amplification of the MYCN proto-oncogene and increased neoangiogenesis ...
Raul Calero, Esther Morchon, John Inge Johnsen, Rosario Serrano   +3 more
doaj   +1 more source

Delving Into Retinoblastoma Genetics: Discovery of Novel Mutations and Their Clinical Impact: Retrospective Cohort Study

Cancer Medicine, Volume 14, Issue 9, May 2025.
A comprehensive outline of the study, detailing the process from DNA extraction to the evaluation of RB1 mutations in relation to clinical features and patient outcomes. ABSTRACT Background Retinoblastoma (Rb) is a rare intraocular malignancy that originates in the retina of children under 5 years of age.
Mohammad Faranoush, Masood Naseripour, Pooya Faranoush, Zeinab Davoodi‐Moghaddam, Alireza Jahandideh, Negin Sadighnia, Delbar Daneshjou, Parisa Shams, Ahad Sedaghat, Reza Mirshahi, Shirin Ravanbod, Farzaneh Nasirnejad, Ali Elahinia, Davood Bashash   +13 more
wiley   +1 more source

Interaction of planetary nebulae, Eta-Carinae and supernova remnants with the Interstellar Medium [PDF]

Interstellar Medium : New research (Nova Science Publishers, Inc., Hauppauge, NY) pp 91-146 (2012), 2012
The image of planetary nebulae (PN), supernova remnant (SNR) and Eta-Carinae is made by three different physical processes. The first process is the expansion of the shell that can be modeled by the canonical laws of motion in the spherical case and by the momentum conservation when gradients of density are present in the interstellar medium.
arxiv  

Genetic variation associated with childhood and adult stature and risk of MYCN‐amplified neuroblastoma

Cancer Medicine, 2020
Background Neuroblastoma is the most common pediatric solid tumor. MYCN‐amplification is an important negative prognostic indicator and inherited genetic contributions to risk are incompletely understood.
Eleanor C. Semmes, Erica Shen, Jennifer L. Cohen, Chenan Zhang, Qingyi Wei, Jillian H. Hurst, Kyle M. Walsh   +6 more
doaj   +1 more source

Role of Exosome in Solid Cancer Progression and Its Potential Therapeutics in Cancer Treatment

Cancer Medicine, Volume 14, Issue 9, May 2025.
Exosomes are small extracellular vesicles that facilitate cellular communication and play a significant role in cancer progression by transferring molecules like miRNA and lncRNA within the tumor microenvironment. This review explores how exosomes derived from various cells influence solid cancer growth by activating pathways critical to tumor ...
Nada Aakel, Rawdhah Mohammed, Assela Fathima, Rabia Kerzabi, Atiyeh Abdallah, Wisam Nabeel Ibrahim   +5 more
wiley   +1 more source

Unified view of quantum amplification based on quantum transformation [PDF]

arXiv, 2016
A general framework of quantum state amplification using the language of quantum state transformation is given systematically for the first time. The concept of amplification of quantum states is defined specifically and the amplification of a set of quantum states is formulated generally as the transformation of quantum states.
arxiv  

Large 1p36 Deletions Affecting Arid1a Locus Facilitate Mycn-Driven Oncogenesis in Neuroblastoma

Cell Reports, 2020
Summary: Loss of heterozygosity (LOH) at 1p36 occurs in multiple cancers, including neuroblastoma (NBL). MYCN amplification and 1p36 deletions tightly correlate with markers of tumor aggressiveness in NBL.
Jesus García-López, Kirby Wallace, Joel H. Otero, Rachelle Olsen, Yong-dong Wang, David Finkelstein, Brian L. Gudenas, Jerold E. Rehg, Paul Northcott, Andrew M. Davidoff, Kevin W. Freeman   +10 more
doaj  

Inhibition of Purine Metabolism Promotes the Differentiation of Neuroblastoma Driven by MYCN

Cancer Medicine, Volume 14, Issue 9, May 2025.
ABSTRACT Background Neuroblastoma (NB), the common extracranial solid tumor in children, is associated with a poor prognosis, particularly in high‐risk patients. MYCN amplification stands as the most prominent molecular hallmark within this high‐risk subgroup. However, MYCN protein is considered “undruggable” due to its lack of a conventional enzymatic
Yufeng Jiang, Hui Xiao, Yi Yang, Guoyu Chen, Yingwen Zhang, Xiaoyu Wu, Qi Zhang, Qingyi Huang, Hongxiang Gao, Yali Han, Anan Zhang, Dapeng Jiang, Liang Zheng, Yanxin Li, Yijin Gao   +14 more
wiley   +1 more source

MYCN is amplified during S phase, and c‑myb is involved in controlling MYCN expression and amplification in MYCN‑amplified neuroblastoma cell lines

Molecular Medicine Reports, 2018
Neuroblastoma derived from primitive sympathetic neural precursors is a common type of solid tumor in infants. MYCN proto‑oncogene bHLH transcription factor (MYCN) amplification and 1p36 deletion are important factors associated with the poor prognosis of neuroblastoma.
Altungöz, Oğuz, Aygun, Nevim
openaire   +5 more sources

Galactic Spiral Arms by Swing Amplification [PDF]

, 2016
Based on the swing amplification model of Julian and Toomre (1966), we investigate the formation and structure of stellar spirals in disk galaxies. We calculate the pitch angle, wavelengths, and amplification factor of the most amplified mode. We also obtain the fitting formulae of these quantities as a function of the epicycle frequency and Toomre's ...
arxiv   +1 more source