Results 151 to 160 of about 763,886 (286)

A Rapid F0 CRISPR Screen in Zebrafish to Identify Regulator Genes of Neuronal Development in the Enteric Nervous System

Neurogastroenterology &Motility, Volume 37, Issue 5, May 2025.
Our rapid and cost‐effective F0 CRISPR/Cas9‐based screening approach provides a comprehensive framework for the functional evaluation of candidate genes for their role in enteric nervous system (ENS) development and function. This screening approach identifies new potential regulator genes of ENS neurogenesis and provides important first insights into ...
Ann E. Davidson, Nora R. W. Straquadine, Sara A. Cook, Christina G. Liu, Chuhao Nie, Matthew C. Spaulding, Julia Ganz   +6 more
wiley   +1 more source

A multiobjective deep learning approach for predictive classification in Neuroblastoma [PDF]

arXiv, 2017
Neuroblastoma is a strongly heterogeneous cancer with very diverse clinical courses that may vary from spontaneous regression to fatal progression; an accurate patient's risk estimation at diagnosis is essential to design appropriate tumor treatment strategies.
arxiv  

Exon array analysis reveals neuroblastoma tumors have distinct alternative splicing patterns according to stage and MYCN amplification status

BMC Medical Genomics, 2011
BackgroundNeuroblastoma (NB) tumors are well known for their pronounced clinical and molecular heterogeneity. The global gene expression and DNA copy number alterations have been shown to have profound differences in tumors of low or high stage and those
Xiang Guo, Qingrong Chen, Young K. Song, Jun S. Wei, J. Khan   +4 more
semanticscholar   +1 more source

A chemical screen identifies the chemotherapeutic drug topotecan as a specific inhibitor of the B-MYB/MYCN axis in neuroblastoma [PDF]

, 2012
The transcription factor MycN is the prototypical neuroblastoma oncogene and a potential therapeutic target. However, its strong expression caused by gene amplification in about 30% of neuroblastoma patients is a considerable obstacle to the development ...
Cantilena, Sandra, D'Acunto, Walter C., Gnemmi, Ilaria, Sala, Arturo, Sottile, Francesco   +4 more
core   +2 more sources

Meta-analysis of Neuroblastomas Reveals a Skewed ALK Mutation Spectrum in Tumors with MYCN Amplification

Clinical Cancer Research, 2010
Purpose: Activating mutations of the anaplastic lymphoma kinase (ALK) were recently described in neuroblastoma. We carried out a meta-analysis of 709 neuroblastoma tumors to determine their frequency and mutation spectrum in relation to genomic and ...
Sara De Brouwer, K. De Preter, C. Kumps, P. Zabrocki, Michaël Porcu, E. M. Westerhout, Arjan Lakeman, J. Vandesompele, J. Hoebeeck, T. Van Maerken, A. De Paepe, G. Laureys, J. Schulte, A. Schramm, C. van den Broecke, Joëlle Vermeulen, N. Van Roy, K. Beiske, M. Renard, R. Noguera, O. Delattre, I. Janoueix-Lerosey, P. Kogner, T. Martinsson, A. Nakagawara, M. Ohira, H. Caron, A. Eggert, J. Cools, R. Versteeg, F. Speleman   +30 more
semanticscholar   +1 more source

A 6‐year‐old female with synchronous cerebellar and thalamic masses

Brain Pathology, EarlyView.
Wenjun Luo, Cuiyun Sun, Zhendong Jiang, Rongju Zhang, Wengao Zhang, Shizhu Yu   +5 more
wiley   +1 more source

Mouse models of pediatric high-grade gliomas with MYCN amplification reveal intratumoral heterogeneity and lineage signatures. [PDF]

Nat Commun, 2023
Schoof M, Godbole S, Albert TK, Dottermusch M, Walter C, Ballast A, Qin N, Olivera MB, Göbel C, Neyazi S, Holdhof D, Kresbach C, Peter LS, Epplen GD, Thaden V, Spohn M, Blattner-Johnson M, Modemann F, Mynarek M, Rutkowski S, Sill M, Varghese J, Afflerbach AK, Eckhardt A, Münter D, Verma A, Struve N, Jones DTW, Remke M, Neumann JE, Kerl K, Schüller U.   +31 more
europepmc   +1 more source

Neuroblastomas with chromosome 11q loss and single copy MYCN comprise a biologically distinct group of tumours with adverse prognosis [PDF]

, 2001
Neuroblastoma is a heterogeneous tumour and its effective clinical management is dependent on accurate prognostic evaluation. In approximately 25% of patients amplification of the MYCN oncogene is known to be associated with a poor outcome.
Chughtai, S, Genus, T, Luttikhuis, M E M Oude, Mann, J R, McConville, C M, Powell, J E, Ramani, P, Rees, S A   +7 more
core   +2 more sources

Critical Role for GAB2 in Neuroblastoma Pathogenesis through the Promotion of SHP2/MYCN Cooperation

Cell Reports, 2017
Growing evidence suggests a major role for Src-homology-2-domain-containing phosphatase 2 (SHP2/PTPN11) in MYCN-driven high-risk neuroblastoma, although biologic confirmation and a plausible mechanism for this contribution are lacking.
Xiaoling Zhang, Zhiwei Dong, Cheng Zhang, Choong Yong Ung, Shuning He, Ting Tao, Andre M. Oliveira, Alexander Meves, Baoan Ji, A. Thomas Look, Hu Li, Benjamin G. Neel, Shizhen Zhu   +12 more
doaj   +1 more source

High Genomic Instability Predicts Survival in Metastatic High-Risk Neuroblastoma

Neoplasia: An International Journal for Oncology Research, 2012
We aimed to identify novel molecular prognostic markers to better predict relapse risk estimate for children with high-risk (HR) metastatic neuroblastoma (NB). We performed genome- and/or transcriptome-wide analyses of 129 stage 4 HR NBs.
Sara Stigliani, Simona Coco, Stefano Moretti, Andrè Oberthuer, Mattias Fischer, Jessica Theissen, Fabio Gallox, Alberto Garavent, Frank Berthold, Stefano Bonassi, Gian Paolo Tonini, Paola Scaruffi   +11 more
doaj   +1 more source