Results 11 to 20 of about 763,886 (286)

Spinal Cord Ependymomas With MYCN Amplification Show Aggressive Clinical Behavior [PDF]

Journal of Neuropathology & Experimental Neurology, 2019
Adult spinal cord ependymomas are typically low grade and have a relatively favorable clinical course following gross total resection. We report 4 cases of anaplastic spinal cord ependymoma with MYCN amplification, an exceptionally rare finding.
Amy A. Swanson, Aditya Raghunathan, Robert B. Jenkins, Martina Messing‐Jünger, Torsten Pietsch, Michelle J. Clarke, Timothy J. Kaufmann, Caterina Giannini   +7 more
semanticscholar   +6 more sources

Detection of MYCN Amplification in Serum DNA Using Conventional Polymerase Chain Reaction. [PDF]

J Korean Med Sci, 2016
Neuroblastoma (NB) is the most common extra-cranial solid tumor of childhood and is characterized by a wide range of clinical behaviors. Amplification of MYCN is a well-known poor prognostic factor in NB patients.
Ma Y, Lee JW, Park SJ, Yi ES, Choi YB, Yoo KH, Sung KW, Koo HH.   +7 more
europepmc   +3 more sources

MYCN Amplification Is Associated with Reduced Expression of Genes Encoding γ-Secretase Complex and NOTCH Signaling Components in Neuroblastoma. [PDF]

Int J Mol Sci, 2023
Amplification of the MYCN oncogene is found in ~20% of neuroblastoma (NB) cases and correlates with high-risk disease and poor prognosis. Despite the plethora of studies describing the role of MYCN in NB, the exact molecular mechanisms underlying MYCN’s ...
Agarwal P, Glowacka A, Mahmoud L, Bazzar W, Larsson LG, Alzrigat M.   +5 more
europepmc   +2 more sources

CT-Based Radiomics Signature With Machine Learning Predicts MYCN Amplification in Pediatric Abdominal Neuroblastoma. [PDF]

Front Oncol, 2021
Purpose MYCN amplification plays a critical role in defining high-risk subgroup of patients with neuroblastoma. We aimed to develop and validate the CT-based machine learning models for predicting MYCN amplification in pediatric abdominal neuroblastoma ...
Chen X, Wang H, Huang K, Liu H, Ding H, Zhang L, Zhang T, Yu W, He L.   +8 more
europepmc   +2 more sources

Prediction of MYCN Amplification, 1p and 11q Aberrations in Pediatric Neuroblastoma via Pre-therapy 18F-FDG PET/CT Radiomics. [PDF]

Front Med (Lausanne), 2022
Purpose This study aimed to assess the predictive ability of 18F-FDG PET/CT radiomic features for MYCN, 1p and 11q abnormalities in NB. Method One hundred and twenty-two pediatric patients (median age 3.
Qian L, Yang S, Zhang S, Qin H, Wang W, Kan Y, Liu L, Li J, Zhang H, Yang J.   +9 more
europepmc   +2 more sources

Extracellular Vesicle-Based Method for Detecting MYCN Amplification Status of Pediatric Neuroblastoma. [PDF]

Cancers (Basel), 2022
Simple Summary MYCN gene amplification, the strongest prognostic marker of aggressive neuroblastoma, is detected on invasive biopsy tissues. This study aimed to establish a less invasive method to detect MYCN status based on MYCN mRNA contents in large ...
Panachan J, Rojsirikulchai N, Pongsakul N, Khowawisetsut L, Pongphitcha P, Siriboonpiputtana T, Chareonsirisuthigul T, Phornsarayuth P, Klinkulab N, Jinawath N, Chiangjong W, Anurathapan U, Pattanapanyasat K, Hongeng S, Chutipongtanate S.   +14 more
europepmc   +2 more sources

MYCN amplification plus 1p36 loss of heterozygosity predicts ultra high risk in bone marrow metastatic neuroblastoma [PDF]

Cancer Medicine, 2022
Background This study aimed to better understand the prognostic effect of multiple genetic markers and identify more subpopulations at ultra high risk of poor outcome in bone marrow (BM) metastatic neuroblastoma (NB).
Zhi‐Xia Yue, Tian‐Yu Xing, Wen Zhao, Qian Zhao, Xi‐Si Wang, Yan Su, Chao Gao, Shu‐Guang Liu, Xiao‐Li Ma   +8 more
doaj   +2 more sources

Radiogenomics prediction for MYCN amplification in neuroblastoma: A hypothesis generating study [PDF]

Pediatric Blood & Cancer, 2021
MYCN amplification represents a powerful prognostic factor in neuroblastoma (NB) and may occasionally account for intratumoral heterogeneity. Radiomics is an emerging field of advanced image analysis that aims to extract a large number of quantitative ...
A. Di Giannatale, P. D. Di Paolo, D. Curione, J. Lenkowicz, A. Napolitano, A. Secinaro, P. Tomà, F. Locatelli, A. Castellano, L. Boldrini   +9 more
semanticscholar   +6 more sources

Lipid Metabolic Reprogramming in Embryonal Neoplasms with MYCN Amplification. [PDF]

Cancers (Basel), 2023
Tumor cells reprogram their metabolism, including glucose, glutamine, nucleotide, lipid, and amino acids to meet their enhanced energy demands, redox balance, and requirement of biosynthetic substrates for uncontrolled cell proliferation. Altered lipid metabolism in cancer provides lipids for rapid membrane biogenesis, generates the energy required for
Talapatra J, Reddy MM.
europepmc   +3 more sources

Druggable epigenetic suppression of interferon-induced chemokine expression linked to MYCN amplification in neuroblastoma. [PDF]

J Immunother Cancer, 2021
Background Amplification of the MYCN oncogene is a molecular hallmark of aggressive neuroblastoma (NB), a childhood cancer of the sympathetic nervous system.
Seier JA, Reinhardt J, Saraf K, Ng SS, Layer JP, Corvino D, Althoff K, Giordano FA, Schramm A, Fischer M, Hölzel M.   +10 more
europepmc   +2 more sources