Implementation of the plasma MYCN/NAGK ratio to detect MYCN amplification in patients with neuroblastoma [PDF]
Molecular Oncology, 2020 Detection of amplification of the MYCN gene is essential for determining optimal treatment and estimating prognosis of patients with neuroblastoma (NB).
Yan Su +14 more
doaj +5 more sources
High level MYCN amplification and distinct methylation signature define an aggressive subtype of spinal cord ependymoma [PDF]
Acta Neuropathologica Communications, 2020 We report a novel group of clinically aggressive spinal cord ependymomas characterized by Grade III histology, MYCN amplification, an absence of NF2 alterations or other recurrent pathogenic mutations, and a unique methylation classifier profile.
Mark Raffeld +12 more
doaj +4 more sources
MYCN amplification and ATRX mutations are incompatible in neuroblastoma [PDF]
Nature Communications, 2020 Abstract Aggressive cancers often have activating mutations in growth-controlling oncogenes and inactivating mutations in tumor-suppressor genes. In neuroblastoma, amplification of the MYCN oncogene and inactivation of the ATRX tumor ...
Xiang Chen, Yiping Fan, Beisi Xu
exaly +8 more sources
MYCN amplification plus 1p36 loss of heterozygosity predicts ultra high risk in bone marrow metastatic neuroblastoma [PDF]
Cancer Medicine, 2022 Background This study aimed to better understand the prognostic effect of multiple genetic markers and identify more subpopulations at ultra high risk of poor outcome in bone marrow (BM) metastatic neuroblastoma (NB).
Zhi‐Xia Yue +8 more
doaj +2 more sources
MYCN amplification drives an aggressive form of spinal ependymoma [PDF]
Acta Neuropathologica, 2019 Spinal ependymal tumors form a histologically and molecularly heterogeneous group of tumors with generally good prognosis. However, their treatment can be challenging if infiltration of the spinal cord or dissemination throughout the central nervous system (CNS) occurs and, in these cases, clinical outcome remains poor.
David Reza Norali Ghasemi +2 more
exaly +8 more sources
MYCN amplification defines an aggressive phenotype in IDH‐mutant gliomas [PDF]
The Journal of Pathology: Clinical ResearchIn alignment with the latest WHO classification system, which underscores the integration of molecular alterations in glioma diagnosis and grading, this study investigates the prognostic significance of MYCN amplification in IDH‐mutant gliomas, a ...
Xujun Xie +5 more
doaj +2 more sources
MYCN amplification predicts poor prognosis based on interphase fluorescence in situ hybridization analysis of bone marrow cells in bone marrow metastases of neuroblastoma [PDF]
Cancer Cell International, 2017 Background MYCN gene amplification is related to risk stratification. Therefore it is important to identify accurately the level of the MYCN gene as early as possible in neuroblastoma (NB); however, for patients with bone marrow (BM) metastasis who need ...
Zhi-Xia Yue +10 more
doaj +2 more sources
Predicting MYCN amplification in paediatric neuroblastoma: development and validation of a 18F-FDG PET/CT-based radiomics signature [PDF]
Insights into Imaging, 2023 Objectives To develop and validate an 18F-FDG PET/CT-based clinical-radiological-radiomics nomogram and evaluate its value in the diagnosis of MYCN amplification (MNA) in paediatric neuroblastoma (NB) patients.
Luo-Dan Qian +7 more
doaj +2 more sources
Chromosome band 11q23 deletion predicts poor prognosis in bone marrow metastatic neuroblastoma patients without MYCN amplification [PDF]
Cancer Communications, 2019 Background Interphase fluorescence in situ hybridization (FISH) of bone marrow cells has been confirmed to be a direct and valid method to assess the v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog (MYCN) amplification in ...
Zhi-Xia Yue +8 more
doaj +2 more sources
Nature Communications, 2021 Neuroblastoma (NB) is often driven by MYCN amplification. Here, the authors show that the most frequent genetic lesion, gain of 17q21-ter in NB leads to overexpression of ALYREF, which forms a complex with MYCN, regulating MYCN stability via the ...
Janith Ananda Seneviratne +2 more
exaly +2 more sources