MYCN mediates TFRC-dependent ferroptosis and reveals vulnerabilities in neuroblastoma
Cell Death and Disease, 2021 MYCN amplification is tightly associated with the poor prognosis of pediatric neuroblastoma (NB). The regulation of NB cell death by MYCN represents an important aspect, as it directly contributes to tumor progression and therapeutic resistance. However,
Jin-Xin Bei, Chaoyun Pan, Xiaoqiong Gu
exaly +2 more sources
Enhancer hijacking determines extrachromosomal circular MYCN amplicon architecture in neuroblastoma
Nature Communications, 2020 MYCN amplification is common in neuroblastomas. Here the authors analyse the MYCN amplicon structure and its epigenetic regulation by integrating short- and longread genomic and epigenomic data and find two classes of MYCN amplicons in neuroblastomas ...
Konstantin Helmsauer +2 more
exaly +2 more sources
Radiomics-Based Machine Learning for Determining Amplification Status in Childhood Neuroblastoma: A Systematic Review and Meta-Analysis [PDF]
Technology in Cancer Research & TreatmentIntroduction The MYCN oncogene promotes tumor cell proliferation in neuroblastoma, and its amplification is a well-established marker of poor prognosis. Radiomics-based approaches have shown promise in noninvasively determining MYCN amplification status;
Haoru Wang MD +5 more
doaj +2 more sources
Neoplasia, 2013 Neuroendocrine prostate cancer (NEPC), also referred to as anaplastic prostate cancer, is a lethal tumor that most commonly arises in late stages of prostate adenocarcinoma (PCA) with predilection to metastasize to visceral organs.
Juan Miguel Mosquera +2 more
exaly +3 more sources
Droplet digital PCR as an alternative to FISH for MYCN amplification detection in human neuroblastoma FFPE samples [PDF]
BMC Cancer, 2019 Background MYCN amplification directly correlates with the clinical course of neuroblastoma and poor patient survival, and serves as the most critical negative prognostic marker.
Dinesh Babu Somasundaram +7 more
doaj +2 more sources
EPEN-10. SPINAL EPENDYMOMA WITH MYCN-AMPLIFICATION – A DISEASE OF CHILDHOOD AND YOUNG ADULTHOOD WITH DISMAL PROGNOSIS [PDF]
Neuro Oncol, 2023 David R. Ghasemi +20 more
europepmc +3 more sources
Lipid Metabolic Reprogramming in Embryonal Neoplasms with MYCN Amplification. [PDF]
Cancers (Basel), 2023 Tumor cells reprogram their metabolism, including glucose, glutamine, nucleotide, lipid, and amino acids to meet their enhanced energy demands, redox balance, and requirement of biosynthetic substrates for uncontrolled cell proliferation. Altered lipid metabolism in cancer provides lipids for rapid membrane biogenesis, generates the energy required for
Talapatra J, Reddy MM.
europepmc +3 more sources
Radiogenomics prediction for MYCN amplification in Neuroblastoma: a hypothesis generating study [PDF]
Pediatric Blood & Cancer, 2021 Background: MYCN amplification represents a powerful prognostic factor in neuroblastoma (NB) and may occasionally account for intratumoral heterogeneity. Radiomics is an emerging field of advanced image analysis that aims to extract a large number of quantitative features from standard radiological images, providing valuable clinical information ...
Angela Di Giannatale +9 more
openalex +4 more sources
Effects of preoperative chemotherapy on neuroblastoma with MYCN amplification: a surgeon's perspective. [PDF]
World J Pediatr Surg, 2020 Chui C.
europepmc +3 more sources