Biogenesis of TNF‐α‐insights into proteostasis and inflammation
TNF‐α biogenesis, trafficking, and signalling are tightly and reciprocally coupled to cellular proteostasis systems, including ER chaperones and endoplasmic reticulum‐associated degradation. This bidirectional crosstalk determines whether TNF‐α responses are adaptive or proteotoxic.
Bailasan Haidar +3 more
wiley +1 more source
Identification of Mycobacterium leprae and Mycobacterium lepromatosis Cases with Broad-Range Molecular Assays at a Single Large Reference Laboratory. [PDF]
Olson GS +6 more
europepmc +1 more source
Ligand binding represses bacterial histidine kinase activity by inhibiting its dimerization
PdtaS is a kinase in the pathogen Mycobacterium tuberculosis that senses copper and nitric oxide and controls virulence gene expression, but how the kinase senses these compounds was unclear. We show that PdtaS is active as a dimer with each monomer phosphorylating the other in trans.
Gaurav D. Sankhe +6 more
wiley +1 more source
Zoonotic Nontuberculous Mycobacteria: Transmission Pathways, Laboratory Diagnosis, Detection Methodologies, and One Health Priorities. [PDF]
Maity H +5 more
europepmc +1 more source
Identification of Mycobacteria [PDF]
openaire +2 more sources
CD36‐mediated lipid rewiring in the metabolic adaptation of tumour ecosystems
Nutrient deprivation drives a lipid‐centric shift in tumour metabolic symbiosis and signalling network. CD36 functions as a bidirectional bridge, transferring fatty acids from stromal donors (adipocytes, CAFs) to the ecosystem tumour‐ and microenvironment‐dependently.
Anna Sebestyén +11 more
wiley +1 more source
Post-traumatic Candida infection leading to bilateral wrist rice body tenosynovitis: a case report and literature review. [PDF]
Wang S, Ro H, Xu H, Fang L, Li X.
europepmc +1 more source
Abstract Diisopropyl ether (DIPE) is a branched ether used as a solvent, extractant, and gasoline additive. While aerobic biodegradation of DIPE has been documented, attenuation under anaerobic conditions (typical of groundwater impacted by petroleum hydrocarbons and fuel oxygenates) remains poorly constrained.
Sandra Dworatzek +11 more
wiley +1 more source
Flavin and deazaflavin biosynthesis in mycobacteria: relevance to physiology, implications for drug discovery, MR-1 antigenicity, and vaccine development. [PDF]
Oketade N +4 more
europepmc +1 more source

