Results 171 to 180 of about 66,921 (262)

Naturally Occurring CodY Variants Alter Ligand Binding, DNA Target Affinity, and Virulence in Clostridioides difficile

open access: yesMolecular Microbiology, EarlyView.
Single amino acid substitutions in the global regulator CodY can alter nutrient sensing and virulence regulation in Clostridioides difficile. We show that the CodY(Y146N) and CodY(V58A) variants display altered ligand binding and reduced promoter binding, leading to derepression of toxin regulatory pathways and increased virulence in vivo.
Md Kamrul Hasan   +2 more
wiley   +1 more source

Roles of PknB and CslA in Cell Wall Morphogenesis of Streptomyces

open access: yesMolecular Microbiology, EarlyView.
Streptomyces grow by extending hyphal tips, a process regulated by polarisome complexes anchored by DivIVA. Using a genetic screen based on toxic DivIVA overproduction, we identified the kinase PknB as a key regulator of cell envelope construction.
Marta Derkacz   +7 more
wiley   +1 more source

Toll Like Receptor 4: A Potential Link Between Obesity and Metabolic Diseases

open access: yesObesity Reviews, EarlyView.
ABSTRACT Epidemiological evidence shows that obesity increases the risk of developing metabolic diseases. Nevertheless, the mechanisms behind this connection remain underappreciated. The substantial impact of these disorders on global health has led to extensive research efforts aimed at identifying the pathophysiological links between them.
Ghadeer Alhamar   +4 more
wiley   +1 more source

Real-time bioluminescence imaging of mycobacteria with Akaluc: a novel method for monitoring drug efficacy. [PDF]

open access: yesSci Rep
Islam MS   +10 more
europepmc   +1 more source

Comparison of the Efficacy and Prognosis of Different Treatment Strategies for Spinal Tuberculosis Patients Undergoing Vertebral Augmentation Surgery by Mistake

open access: yesOrthopaedic Surgery, EarlyView.
Based on the clinical characteristics of patients with spinal tuberculosis after percutaneous vertebral augmentation, the corresponding diagnosis and treatment strategies were explored, and clinical data for the differential diagnosis of spinal tuberculosis were provided.
Xiong Xu   +10 more
wiley   +1 more source

Nontuberculosis Mycobacterial Infections: A Series of 14 Cases from a Tertiary Care Center in Türkiye. [PDF]

open access: yesInfect Dis Clin Microbiol
Ertürk D   +9 more
europepmc   +1 more source

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