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Anti-Mycobacterial Drug Resistance in Japan: How to Approach This Problem?
Antibiotics, 2021 Mycobacteriosis is mainly caused by two groups of species: Mycobacterium tuberculosis and non-tuberculosis mycobacteria (NTM). The pathogens cause not only respiratory infections, but also general diseases.
Keisuke Kamada, Satoshi Mitarai
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Scientific Reports, 2021 Mycobacterium tuberculosis (Mtb) is an obligate human pathogen that can adapt to the various nutrients available during its life cycle. However, in the nutritionally stringent environment of the macrophage phagolysosome, Mtb relies mainly on cholesterol.
Jakub Pawełczyk +7 more
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Cobalamin is present in cells of non-tuberculous mycobacteria, but not in Mycobacterium tuberculosis
Scientific Reports, 2021 Cobalamin (vitamin B12) is a structurally complex molecule that acts as a cofactor for enzymes and regulates gene expression through so-called riboswitches.
Alina Minias +4 more
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Frontiers in Microbiology, 2020 MSMEG_4305 is a two-domain protein of Mycolicibacterium smegmatis (Mycobacterium smegmatis) (Mycolicibacterium smegmatis). The N-terminal domain of MSMEG_4305 encodes an RNase H type I.
Bożena Czubat +7 more
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International Journal of Mycobacteriology, 2020 Over the last 30 years, there have been at least 17 published reports of nontuberculous mycobacteria (NTMs) being isolated from hospital ice or ice-making machines.
Beverley Cherie Millar +1 more
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Mesoporous silica nanoparticles containing silver as novel antimycobacterial agents against Mycobacterium tuberculosis [PDF]
Colloids and Surfaces B: Biointerfaces, Volume 197, January 2021,
111405, 2021 Tuberculosis remains today a major public health issue with a total of 9 million new cases and 2 million deaths annually. The lack of an effective vaccine and the increasing emergence of new strains of Mycobacterium tuberculosis (Mtb) highly resistant to antibiotics, anticipate a complicated scenario in the near future.
arxiv +1 more source
Polymorphism in the EREG gene confers susceptibility to tuberculosis
BMC Medical Genetics, 2019 Background Host genetic factors affect the immune response to Mycobacterium tuberculosis (Mtb) infection as well as the progression of the disease. Epiregulin (EREG) belongs to the epidermal growth factor (EGF) family, which binds to the epidermal growth
Wen Cao +7 more
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Frontiers in Microbiology, 2018 A series of structome analyses, that is, quantitative and three-dimensional structural analysis of a whole cell at the electron microscopic level, have already been achieved individually in Exophiala dermatitidis, Saccharomyces cerevisiae, Mycobacterium ...
Hiroyuki Yamada +10 more
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Something Old, Something New: Ion Channel Blockers as Potential Anti-Tuberculosis Agents
Frontiers in Immunology, 2021 Tuberculosis (TB) remains a challenging global health concern and claims more than a million lives every year. We lack an effective vaccine and understanding of what constitutes protective immunity against TB to inform rational vaccine design.
Steven C. Mitini-Nkhoma +13 more
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