Results 31 to 40 of about 79,383 (218)

Synthesis and biological evaluation of NAS-21 and NAS-91 analogues as potential inhibitors of the mycobacterial FAS-II dehydratase enzyme Rv0636 [PDF]

, 2008
The identification of potential new anti-tubercular cemotherapeutics is paramount due to the recent emergence of extensively drug-resistant strains of Mycobacterium tuberculosis (XDR-TB).Libraries of NAS-21 and NAS-91 analogues were synthesized and ...
Besra, Gurdyal S, Bhowruth, Veemal, Brown, Alistair K.   +2 more
core   +2 more sources

Screening vaccine formulations for biological activity using fresh human whole blood. [PDF]

, 2014
Understanding the relevant biological activity of any pharmaceutical formulation destined for human use is crucial. For vaccine-based formulations, activity must reflect the expected immune response, while for non-vaccine therapeutic agents, such as ...
Aboutorabian, Sepideh, Ausar, Salvador F, Brookes, Roger H, Dockrell, Hazel M, Ha, Yukyung, Hakimi, Jalil, Hasija, Manvi, Rahman, Nausheen, Smith, Steven G, Todryk, Stephen M   +9 more
core   +1 more source

Three‐reaction high‐resolution melting assay for rapid differentiation of Mycobacterium tuberculosis complex members

MicrobiologyOpen, 2019
The possibility of introducing a reliable assay for a quick identification and differentiation of the main species of Mycobacterium tuberculosis complex (MTBC) supports the improvement of efficient tuberculosis combating strategies worldwide ...
Patricia Landolt, Roger Stephan, Marc J. A. Stevens, Simone Scherrer   +3 more
doaj   +1 more source

Human tuberculosis - an ancient disease, as elucidated by ancient microbial biomolecules [PDF]

, 2009
Tuberculosis is a major cause of death but infected people with effective immunity may remain healthy for years, suggesting long-term coexistence of host and pathogen.
Donoghue, HD
core   +1 more source

The VetMAX™ M. tuberculosis complex PCR kit detects MTBC DNA in antemortem and postmortem samples from white rhinoceros (Ceratotherium simum), African elephants (Loxodonta africana) and African buffaloes (Syncerus caffer)

BMC Veterinary Research, 2020
Background Bovine tuberculosis and tuberculosis are chronic infectious diseases caused by the Mycobacterium tuberculosis complex members, Mycobacterium bovis and Mycobacterium tuberculosis, respectively. Infection with M. bovis and M.
Wynand J. Goosen, Tanya J. Kerr, Léanie Kleynhans, Peter Buss, David Cooper, Robin M. Warren, Paul D. van Helden, Björn Schröder, Sven D. C. Parsons, Michele A. Miller   +9 more
doaj   +1 more source

cDNA-RNA subtractive hybridization reveals increased expression of mycocerosic acid synthase in intracellular Mycobacterium bovis BCG. [PDF]

, 2001
Identifying genes that are differentially expressed by Mycobacterium bovis BCG after phagocytosis by macrophages will facilitate the understanding of the molecular mechanisms of host cell-intracellular pathogen interactions. To identify such genes a cDNA-
Centre Gunnels Wood, Irene M. Monahan, Joseph A. Mangan, Martin J. Everett, Ming-shi Li, Philip D. Butcher, Simon J. Waddell, Steve L. Martin   +7 more
core   +3 more sources

Performance of an environmental test to detect Mycobacterium bovis infection in badger social groups [PDF]

, 2007
A study by Courtenay and others (2006) demonstrated that the probability of detecting Mycobacterium bovis by PCR in soil samples from the spoil heaps of main badger setts correlated with the prevalence of excretion (infectiousness) of captured ...
Cheeseman, C. L., Courtenay, Orin, Delahay, Richard J., Keeling, Matthew James, Macdonald, David W., Reilly, L. A., Sweeney, F. P., Wellington, E. M. H., Wilson, G. J.   +8 more
core   +1 more source

Molecular epidemiology of Mycobacterium africanum in Ghana [PDF]

, 2016
BACKGROUND: Mycobacterium africanum comprises two phylogenetic lineages within the M. tuberculosis complex (MTBC) and is an important cause of human tuberculosis (TB) in West Africa. The reasons for this geographic restriction of M.
Ahorlu, Collins, Asante-Poku, Adwoa, Baddoo, Akosua, Bonsu, Frank, Borrell, Sonia, Forson, Audrey, Gagneux, Sebastien, Hattendorf, Jan, Koram, Kwadwo A., Laryea, Clement, Osei-Wusu, Stephen, Otchere, Isaac Darko, Sarpong, Esther, Yeboah-Manu, Dorothy   +13 more
core   +2 more sources

Systems-based approaches to probing metabolic variation within the Mycobacterium tuberculosis complex. [PDF]

PLoS ONE, 2013
The Mycobacterium tuberculosis complex includes bovine and human strains of the tuberculosis bacillus, including Mycobacterium tuberculosis, Mycobacterium bovis and the Mycobacterium bovis BCG vaccine strain. M. bovis has evolved from a M.
Emma K Lofthouse, Paul R Wheeler, Dany J V Beste, Bhagwati L Khatri, Huihai Wu, Tom A Mendum, Andrzej M Kierzek, Johnjoe McFadden   +7 more
doaj   +1 more source

Whole-transcriptome, high-throughput RNA sequence analysis of the bovine macrophage response to Mycobacterium bovis infection in vitro [PDF]

, 2013
BACKGROUND: Mycobacterium bovis, the causative agent of bovine tuberculosis, is an intracellular pathogen that can persist inside host macrophages during infection via a diverse range of mechanisms that subvert the host immune response.
Browne, JA, Conlon, KM, Gordon, SV, Gormley, E, Hokamp, K, Killick, KE, Loftus, BJ, Lohan, AJ, MacHugh, DE, Magee, DA, Nalpas, NC, Park, SD, Rue-Albrecht, K, Taraktsoglou, M   +13 more
core   +2 more sources