Results 31 to 40 of about 601,814 (124)
Nature Genetics, 2016 Generalist and specialist species differ in the breadth of their ecological niches. Little is known about the niche width of obligate human pathogens.
David Stucki +74 more
semanticscholar +1 more source
Deciphering a Sleeping Pathogen: Uncovering Novel Transcriptional Regulators of Hypoxia-Induced Dormancy in Mycobacterium Tuberculosis [PDF]
arXiv, 2023 Along the pathogenesis of Mycobacterium Tuberculosis (MTB), hypoxia-induced dormancy is a process involving the oxygen-depleted environment encountered inside the lung granuloma, where bacilli enter a viable, non-replicating state termed as latency. Affecting nearly two billion people, latent TB can linger in the host for indefinite periods of time ...
arxiv
Cytokines and Chemokines in Mycobacterium tuberculosis Infection
Microbiology spectrum, 2016 Chemokines and cytokines are critical for initiating and coordinating the organized and sequential recruitment and activation of cells into Mycobacterium tuberculosis-infected lungs. Correct mononuclear cellular recruitment and localization are essential
Racquel Domingo-Gonzalez +3 more
semanticscholar +1 more source
Drug Resistance in Mycobacterium tuberculosis
Mycobacterium - Research and Development, 2017 Tuberculosis (TB) remains to be a serious health problem worldwide. There is an increased transmission of Mycobacterium tuberculosis strains with drug resistance, hence complicat‐ ing TB control. The deciphering of the M.
K. Peñuelas-Urquides +3 more
semanticscholar +1 more source
Structural Properties of an S-system Model of Mycobacterium Tuberculosis Gene Regulation [PDF]
arXiv, 2020 Magombedze and Mulder in 2013 studied the gene regulatory system of Mycobacterium Tuberculosis (Mtb) by partitioning this into three subsystems based on putative gene function and role in dormancy/latency development. Each subsystem, in the form of S-system, is represented by an embedded chemical reaction network (CRN), defined by a species subset and ...
arxiv
Deterministic and Stochastic in-host Tuberculosis Models for Bacterium-directed and Host-directed Therapy Combination [PDF]
arXiv, 2021 Mycobacterium tuberculosis infection can involve all immune system components and can result in different disease outcomes. The antibiotic TB drugs require strict adherence to prevent both disease relapse and mutation of drug- and multidrug-resistant strains.
arxiv
PhD Thesis. Computer-Aided Assessment of Tuberculosis with Radiological Imaging: From rule-based methods to Deep Learning [PDF]
arXiv, 2022 Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis (Mtb.) that produces pulmonary damage due to its airborne nature. This fact facilitates the disease fast-spreading, which, according to the World Health Organization (WHO), in 2021 caused 1.2 million deaths and 9.9 million new cases.
arxiv
mBio, 2017 The cell wall of Mycobacterium tuberculosis is composed of unique lipids that are important for pathogenesis. Indeed, the first-ever genetic screen in M. tuberculosis identified genes involved in the biosynthesis and transport of the cell wall lipid PDIM
Jeffrey Quigley +5 more
semanticscholar +1 more source
Journal of Immunology, 2016 Recent advances in immunometabolism link metabolic changes in stimulated macrophages to production of IL-1β, a crucial cytokine in the innate immune response to Mycobacterium tuberculosis.
Laura E. Gleeson +7 more
semanticscholar +1 more source
Extreme Drug Tolerance of Mycobacterium tuberculosis in Caseum
Antimicrobial Agents and Chemotherapy, 2017 Tuberculosis (TB) recently became the leading infectious cause of death in adults, while attempts to shorten therapy have largely failed. Dormancy, persistence, and drug tolerance are among the factors driving the long therapy duration. Assays to measure
Jansy P. Sarathy +7 more
semanticscholar +1 more source