Results 81 to 90 of about 843,867 (389)

Loss of NR2F6 Protects from Salmonella Typhimurium Infection

Advanced Science, EarlyView.
Loss of nuclear receptor NR2F6 reduces tissue‐resident macrophage populations. Nr2f6‐deficient mice are protected from weight loss and bacterial load during infection with Salmonella Typhimurium. Pro‐inflammatory cytokines and iron levels are altered in infected Nr2f6‐deficient mice.
Johannes Woelk, Christa Pfeifhofer‐Obermair, Julia Benz, Natascha Brigo, Milena Bamberger, Alexeja Kleiter, Martin Hermann, Guenter Weiss, Natascha Hermann‐Kleiter   +8 more
wiley   +1 more source

Minimum Inhibitory Concentrations before and after Antibacterial Treatment in Patients with Mycobacterium abscessus Pulmonary Disease

Microbiology Spectrum, 2021
The clinical importance of Mycobacterium abscessus (MABS) pulmonary disease has been increasing. However, there is still a lack of information about MIC distribution patterns and changes in clinical practice settings.
Keiji Fujiwara, Fumiko Uesugi, Koji Furuuchi, Yoshiaki Tanaka, Takashi Yoshiyama, Mikio Saotome, Ken Ohta, Satoshi Mitarai, Kozo Morimoto   +8 more
doaj   +1 more source

Integrated Transcriptome and Metabolomics Analyses Show MYC as a Potential Therapeutic Target for Behçet's Uveitis

Advanced Science, EarlyView.
Integrated single‐cell transcriptomic and metabolomic analyses reveal that MYC‐driven glycolysis activates the PI3K‐AKT‐FOXO1 pathway, disrupting Th17/Treg balance and promoting uveitis. MYC inhibition restores immune homeostasis and alleviates disease symptoms.
He Li, Lei Zhu, Zhaohuai Li, Yihan Zhang, Genxian Zhang, Xuening Peng, Dongting Wu, Qi Jiang, Rong Wang, Renbing Jia, Song Guo Zheng, Wenru Su   +11 more
wiley   +1 more source

Different transcriptional profiles of RAW264.7 infected with Mycobacterium tuberculosis H37Rv and BCG identified via deep sequencing. [PDF]

PLoS ONE, 2012
BACKGROUND: The Mycobacterium tuberculosis H37Rv and BCG effects on the host cell transcriptional profile consider a main research point. In the present study the transcriptome profiling analysis of RAW264.7 either infected with Mycobacterium ...
Fengguang Pan, Yaya Zhao, Seng Zhu, Changjiang Sun, Liancheng Lei, Xin Feng, Wen Yu Han   +6 more
doaj   +1 more source

Castor Plant (Ricinus communis L.) Leaf Extract as Potential Antibacterial Against The Growth of Mycobacterium Tuberculosis

Folia Medica Indonesiana, 2022
Highlight : • Patients experiencing failure of first-line drug and developing multidrug resistant tuberculosis (MDR-TB) has increased throughout 2011-2015.
Fikriaddin Syafiq Istaufa, Yoyok Subagio, Irma Suswati, Isbandiyah   +3 more
doaj   +1 more source

Discriminatory ability of hypervariable variable number tandem repeat loci in population-based analysis of Mycobacterium tuberculosis strains, London, UK [PDF]

, 2009
To address conflicting results about the stability of variable number tandem repeat (VNTR) loci and their value in prospective molecular epidemiology of Mycobacterium tuberculosis, we conducted a large prospective population-based analysis of all M ...
Brown, T, Drobniewski, FA, Nikolayevskyy, VN, Velji, P   +3 more
core   +3 more sources

Type I Interferon Signaling Augments Autoimmunity in Neuromyelitis Optica Spectrum Disorder

Advanced Science, EarlyView.
The cGAS‐STING innate immune pathway is excessively activated both in peripheral monocytes and CNS microglia in patients with NMOSD, leading to an overproduction of IFN‐I. IFN‐I subsequently acts on AQP4‐specific autoreactive T cells. Blocking this pathway may offer novel therapeutic options for individuals with NMOSD.
Tian‐Xiang Zhang, Xiaoxiao Yang, Xue Gao, Xiaoshan Du, Xuegan Lian, Naiyuan Shao, Ye Liu, Zhenning Huang, Dongmei Jia, Alexander Y. L. Lau, Zhiguo Li, Zaal Kokaia, Fu‐Dong Shi, Chao Zhang   +13 more
wiley   +1 more source

Laboratory-based surveillance of nontuberculous mycobacterial pulmonary disease in Japan

ERJ Open Research
Background Intractable pulmonary diseases with nontuberculous mycobacteria (NTM-PDs) and antimicrobial resistance have become increasingly concerning worldwide.
Yuko Hamaguchi, Kozo Morimoto, Satoshi Mitarai   +2 more
doaj   +1 more source

Frequent transmission of the Mycobacterium tuberculosis Beijing lineage and positive selection for EsxW Beijing variant in Vietnam

Nature Genetics, 2018
To examine the transmission dynamics of Mycobacterium tuberculosis (Mtb) isolated from tuberculosis patients in Ho Chi Minh City, Vietnam, we sequenced the whole genomes of 1,635 isolates and compared these with 3,144 isolates from elsewhere.
K. Holt, P. McAdam, P. V. Thai, N. Thuong, D. M. Ha, N. Lan, N. H. Lân, Nguyen Thi Quynh Nhu, H. Hai, V. T. N. Ha, G. Thwaites, David J. Edwards, A. Nath, K. Pham, D. Ascher, J. Farrar, C. Khor, Y. Teo, M. Inouye, M. Caws, S. Dunstan   +20 more
semanticscholar   +1 more source

Mycobacterium tuberculosis in Taiwan

Journal of Infection, 2006
The resurgence of tuberculosis (TB) and the emergence of drug resistance of Mycobacterium tuberculosis (MTB) isolates are of great impact on public health.Taiwanese data on disease burden of TB and anti-microbial resistance of MTB identified from Annual Reports of Centre for Disease Control, Department of Health, Taiwan and from peer-reviewed ...
Hsueh Po-Ren, Liu Yung-Ching, So Jen, Liu Cheng-Yi, Yang Pan-Chyr, Luh Kwen-Tay   +5 more
openaire   +3 more sources