Results 51 to 60 of about 7,057 (208)

A conditional mutant of the fatty acid synthase unveils unexpected cross talks in mycobacterial lipid metabolism [PDF]

Open Biology, 2017
Unlike most bacteria, mycobacteria rely on the multi-domain enzyme eukaryote-like fatty acid synthase I (FAS I) to make fatty acids de novo. These metabolites are precursors of the biosynthesis of most of the lipids present both in the complex ...
Matías Cabruja, Sonia Mondino, Yi Ting Tsai, Julia Lara, Hugo Gramajo, Gabriela Gago   +5 more
doaj   +1 more source

The Molecular Genetics of Mycolic Acid Biosynthesis

Microbiology Spectrum, 2014
ABSTRACT Mycolic acids are major and specific long-chain fatty acids that represent essential components of the Mycobacterium tuberculosis cell envelope. They play a crucial role in the cell wall architecture and impermeability, hence the natural resistance of mycobacteria to most antibiotics, and ...
Jakub, PaweŁczyk, Laurent, Kremer
openaire   +2 more sources

Detecting Ancient Tuberculosis

Internet Archaeology, 1998
Some diseases have played a more significant role in human development than others. Here we describe the results of a trial to diagnose ancient tuberculosis using chemical methods. Palaeo-epidemiological studies of the disease are compromised, but it has
Angela M. Gernaey , David E. Minnikin , Mark S. Copley , Jacinda J. Power , Ali M. S. Ahmed , Ronald A. Dixon, Charlotte A. Roberts , Duncan J. Robertson, John Nolan , Andrew Chamberlain   +9 more
doaj   +1 more source

Adhesive and conformational behaviour of mycolic acid monolayers [PDF]

Biochimica et Biophysica Acta (BBA) - Biomembranes, 2010
We have studied the pH-dependent interaction between mycolic acid (MA) monolayers and hydrophobic and hydrophilic surfaces using molecular (colloidal probe) force spectroscopy. In both cases, hydrophobic and hydrophilic monolayers (prepared by Langmuir-Blodgett and Langmuir-Schaefer deposition on silicon or hydrophobized silicon substrates ...
Zhang, Zhenyu, Pen, Yu, Edyvean, Robert G. J., Banwart, Steven A., Dalgliesh, Robert M., Geoghegan, Mark   +5 more
openaire   +5 more sources

A Wagner–Meerwein‐Like Rearrangement Generates a Vinyl Group in the Biosynthesis of the Polychlorinated Lipopeptides Fischerazoles

Angewandte Chemie International Edition, EarlyView.
The fischerazoles, unusual cyanobacterial chlorinated lipopeptides are reported. During their biosynthesis, a linear fatty acyl‐acyl carrier protein (ACP) precursor is rearranged through the action of the S‐adenosyl‐methionine (SAM)‐dependent methyltransferase FshF, to generate a pendant vinyl group.
Sandra A. C. Figueiredo, Kathleen Abt, Konrad Viehrig, Peter J. Jervis, Teresa P. Martins, Iñaki Lacomba, Chuhan Li, Daniele Castagnolo, Pedro N. Leão   +8 more
wiley   +1 more source

Synthesis, antitubercular activity and mechanism of resistance of highly effective thiacetazone analogues. [PDF]

PLoS ONE, 2013
Defining the pharmacological target(s) of currently used drugs and developing new analogues with greater potency are both important aspects of the search for agents that are effective against drug-sensitive and drug-resistant Mycobacterium tuberculosis ...
Geoffrey D Coxon, Derek Craig, Rosa Milagros Corrales, Emilie Vialla, Laila Gannoun-Zaki, Laurent Kremer   +5 more
doaj   +1 more source

Proteome Analysis of Corynebacterium diphtheriae–Macrophage Interaction

PROTEOMICS, EarlyView.
ABSTRACT Contact of Corynebacterium diphtheriae with macrophages induces adaptations on both bacterial and cellular sides. The study presented here was aiming to shed light on the simultaneous intracellular adaptation of the bacteria and changes in the proteome of the phagocytes in response to the internalization of C. diphtheriae.
Luca Musella, Jens Möller, Christopher Lischer, Julio Vera‐Gonzalez, Jörg Hofmann, Lisa Ott, Andreas Burkovski   +6 more
wiley   +1 more source

Analysis of Corynebacterium diphtheriae macrophage interaction: Dispensability of corynomycolic acids for inhibition of phagolysosome maturation and identification of a new gene involved in synthesis of the corynomycolic acid layer. [PDF]

PLoS ONE, 2017
Corynebacterium diphtheriae is the causative agent of diphtheria, a toxin mediated disease of upper respiratory tract, which can be fatal. As a member of the CMNR group, C.
Lisa Ott, Elena Hacker, Timo Kunert, Ian Karrington, Philipp Etschel, Roland Lang, Veit Wiesmann, Thomas Wittenberg, Albel Singh, Cristian Varela, Apoorva Bhatt, Vartul Sangal, Andreas Burkovski   +12 more
doaj   +1 more source

The Mycobacterium tuberculosis Rv0132c Gene Product Mtb‐FGD2 Can Act as an F420‐Dependent Glucose Dehydrogenase

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT The role of the cell envelope‐associated Rv0132c/FGD2 from Mycobacterium tuberculosis has long been a subject of debate. Importantly, FGD2 is found only in pathogenic mycobacteria, making it a potential drug target. While some suggest it functions as a glucose‐6‐phosphate dehydrogenase, others propose it acts instead as an F420‐dependent ...
Adewale V. Aderemi, Matthew Snee, Richard B. Tunnicliffe, Linus O. Johanissen, Matthew J. Cliff, Colin W. Levy, Derren J. Heyes, Marina Golovanova, Thomas A. Jowitt, Sam Hay, Andrew W. Munro, Jonathan P. Waltho, David Leys   +12 more
wiley   +1 more source

Mycolic acids: structure, biosynthesis and physiological functions [PDF]

Progress in Lipid Research, 1998
n ...
Barry, Clifton E., Lee, Richard E., Mdluli, Khisimusi, Sampson, Andrea E., Schroeder, Benjamin G., Slayden, Richard A., Yuan, Ying   +6 more
openaire   +2 more sources