Results 41 to 50 of about 7,057 (208)

Identification of a Desaturase Involved in Mycolic Acid Biosynthesis in Mycobacterium smegmatis.

PLoS ONE, 2016
Mycolic acids are unique long chain fatty acids found in the cell walls of mycobacteria including the tubercle bacillus, Mycobacterium tuberculosis. The introduction of double bonds in mycolic acids remains poorly understood, however, genes encoding two ...
Albel Singh, Cristian Varela, Kiranmai Bhatt, Natacha Veerapen, Oona Y C Lee, Houdini H T Wu, Gurdyal S Besra, David E Minnikin, Nagatoshi Fujiwara, Kanae Teramoto, Apoorva Bhatt   +10 more
doaj   +1 more source

Phytochemical Molecules Binding with the Proteins of Mycolic Acid Synthesis Pathway of Mycobacterium tuberculosis

Journal of Molecular Docking, 2022
Resistance against anti-tubercular drugs is a significant problem. This elucidates the need for novel drug targets. Altering and targeting the enzymes involved in cell wall synthesis led to fatal damage to the bacterial cell. Mycolic acids are critically
Rishabh Gaur, Praveen Kumar Anand
doaj   +1 more source

Identifying the Novel Inhibitors Against the Mycolic Acid Biosynthesis Pathway Target “mtFabH” of Mycobacterium tuberculosis

Frontiers in Microbiology, 2022
Mycolic acids are the key constituents of mycobacterial cell wall, which protect the bacteria from antibiotic susceptibility, helping to subvert and escape from the host immune system.
Niranjan Kumar, Rakesh Srivastava, Raj Kumar Mongre, Raj Kumar Mongre, Chandra Bhushan Mishra, Amit Kumar, Amit Kumar, Rosy Khatoon, Atanu Banerjee, Md Ashraf-Uz-Zaman, Harpreet Singh, Andrew M. Lynn, Myeong-Sok Lee, Amresh Prakash   +13 more
doaj   +1 more source

Structure–function relationships of the antigenicity of mycolic acids in tuberculosis patients

Chemistry and Physics of Lipids, 2010
Mervyn Beukes, Yolandy Lemmer, Juma'A R Al Dulayymi   +2 more
exaly   +2 more sources

Unsupported planar lipid membranes formed from mycolic acids of Mycobacterium tuberculosis

Journal of Lipid Research, 2011
The cell wall of mycobacteria includes a thick, robust, and highly impermeable outer membrane made from long-chain mycolic acids. These outer membranes form a primary layer of protection for mycobacteria and directly contribute to the virulence of ...
Kyle W. Langford, Boyan Penkov, Ian M. Derrington, Jens H. Gundlach   +3 more
doaj   +1 more source

Phylogeny Trumps Chemotaxonomy: A Case Study Involving Turicella otitidis

Frontiers in Microbiology, 2018
The genus Turicella was proposed to harbor clinical strains isolated from middle-ear fluids of patients with otitis media. 16S rRNA phylogeny showed that it belonged to the mycolic acid-containing actinobacteria, currently classified in the order ...
Inwoo Baek, Inwoo Baek, Mincheol Kim, Imchang Lee, Imchang Lee, Seong-In Na, Seong-In Na, Michael Goodfellow, Jongsik Chun, Jongsik Chun, Jongsik Chun   +10 more
doaj   +1 more source

Phage resistance profiling identifies new genes required for biogenesis and modification of the corynebacterial cell envelope

eLife, 2022
Bacteria of the order Corynebacteriales including pathogens such as Mycobacterium tuberculosis and Corynebacterium diphtheriae are characterized by their complex, multi-layered envelope.
Amelia C McKitterick, Thomas G Bernhardt
doaj   +1 more source

Site of inhibitory action of isoniazid in the synthesis of mycolic acids in Mycobacterium tuberculosis

Journal of Lipid Research, 1975
The cellular mycolate synthetase activity of Mycobacterium tuberculosis H37Ra was previously shown to be very sensitive to isoniazid (Wang, L., and K. Takayama. 1972. Antimicrob. Agents Chemother. 2: 438-441).
K. Takayama, H.K. Schnoes, E.L. Armstrong, R.W. Boyle   +3 more
doaj   +1 more source

Click-chemistry approach to study mycoloylated proteins: Evidence for PorB and PorC porins mycoloylation in Corynebacterium glutamicum. [PDF]

PLoS ONE, 2017
Protein mycoloylation is a recently identified, new form of protein acylation. This post-translational modification consists in the covalent attachment of mycolic acids residues to serine.
Hanane Issa, Emilie Huc-Claustre, Thamila Reddad, Nolwenn Bonadé Bottino, Maryelle Tropis, Christine Houssin, Mamadou Daffé, Nicolas Bayan, Nathalie Dautin   +8 more
doaj   +1 more source

Mycolic Acids: Structures, Biosynthesis, and Beyond

Chemistry & Biology, 2014
Mycolic acids are major and specific lipid components of the mycobacterial cell envelope and are essential for the survival of members of the genus Mycobacterium that contains the causative agents of both tuberculosis and leprosy. In the alarming context of the emergence of multidrug-resistant, extremely drug-resistant, and totally drug-resistant ...
Marrakchi, Hedia, Lanéelle, Marie-Antoinette, Daffé, Mamadou   +2 more
openaire   +2 more sources