Results 101 to 110 of about 173,583 (299)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Characteristics of the respiratory season in 2022—23 and 2023—24 according to data from the city children's hospital

Детские инфекции (Москва)
The end of the COVID-19 pandemic in the respiratory disease season of 2022—23 was characterized by an increase in the number of cases, a shift in the classic peaks of morbidity for various infections, and a predominance of influenza and respiratory ...
Е. М. Tolstova, М. А. Nikonova, О. V. Zaytseva, N. S. Zaitseva, Е. Е. Lokshina, М. V. Besedina, S. R. Kuzina, Е. V. Kulikova, Т. Yu. Belyaeva   +8 more
doaj   +1 more source

Model based on the automated AI-driven CT quantification is effective for the diagnosis of refractory Mycoplasma pneumoniae pneumonia [PDF]

Yali Qian, Yunxi Tao, Lihui Wu, Changsheng Zhou, Feng Liu, Shenglong Xu, Hongjun Miao, Xiucheng Gao, Xuhua Ge   +8 more
openalex   +1 more source

Antigen heterogeneity among isolates of Mycoplasma bovis is generated by high-frequency variation of diverse membrane surface proteins [PDF]

, 1994
Renate Rosengarten, A Behrens, A Stetefeld, Martin Heller, M Ahrens, Konrad Sachse, David Yogev, H. Kirchhoff   +7 more
openalex   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Independent Predictors of Mycoplasma pneumoniae Infection: A Retrospective Cohort Study Among Hospitalized Adults in an East Texas Health Facility

Journal of Respiration
Background: Community-acquired pneumonia in the United States accounts for over five million cases annually, with an estimated one million hospitalizations.
Menkeoma Laura Okoli, Ibuchim Chinemerem Okoli, Abuoma Chisom Okoli, Ikechukwu Umezurike, Celestine Ishiekwene   +4 more
doaj   +1 more source

Immune Response of Gnotobiotic Piglets against Mycoplasma hyopneumoniae

, 2008
Yoshihiro Muneta, Yu Minagawa, Yoshihiro Shimoji, Yohsuke Ogawa, Hirokazu Hikono, Yasuyuki Mori   +5 more
openalex   +2 more sources

Allelic polymorphisms at the H-2A and HLA-DQ loci influence the response of murine lymphocytes to the Mycoplasma arthritidis superantigen MAM [PDF]

, 1997
B C Cole, Allen D. Sawitzke, E A Ahmed, Curtis L. Atkin, Chella S. David   +4 more
openalex   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source