Results 191 to 200 of about 85,956 (299)

Histiocytes: Multifaceted Regulators of Health and Disease

Veterinary Clinical Pathology, EarlyView.
ABSTRACT The mononuclear phagocyte system encompasses macrophages, dendritic cells (DCs), and monocytes. Tissue‐resident macrophages and dendritic cells arise during embryogenesis and are replenished either through self‐renewal or by monocytes during inflammation.
Erika J. Gruber
wiley   +1 more source

Heat stress enhances gut microbial arginine catabolism to amplify MyD88-dependent inflammatory responses. [PDF]

Microbiome
Ye X, Cai Q, Pan Y, Xu M, Li Y, You M, Yang J, Chen S, He H, Hong G, Zheng H.   +10 more
europepmc   +1 more source

From contamination to fever: The role of endotoxin levels in bacterially contaminated platelet concentrates

Vox Sanguinis, EarlyView.
Abstract Background and Objectives Growth of gram‐negative bacteria in a platelet concentrate (PC) is inevitably accompanied by the accumulation of endotoxin, which is the major component of the outer cell membrane of these organisms. However, less is known about the kinetics of endotoxin accumulation in PC and its biological activity.
Marcel Prax, Lea Debes, Paul Adomeit, Michel‐Andrés García‐Otálora, Carl P. McDonald, Marc Cloutier, Ute Gravemann, Opeyemi Adesina, Morenike Adeoye‐Isijola, Josephine Hubloher, Hellen Sarela, Tanja Vollmer, Oleg Krut, Sandra Ramirez‐Arcos, ISBT Transfusion‐Transmitted Infectious Diseases Working Party “Subgroup on Bacteria”   +14 more
wiley   +1 more source

Electroacupuncture Attenuates Neuroinflammation in PCPA-Induced Insomnia Rats by Suppressing the TLR4/MyD88/NF-κB p65 Pathway and M1 Microglial Activation. [PDF]

Neuropsychiatr Dis Treat
Zhang M, Liu L, Tan T, He L, Hu B, Li S, Jiang M, Deng P, Ren Q.   +8 more
europepmc   +1 more source

MYD88 Protein Variant [PDF]

, 2020
openaire   +1 more source

Role of RIPK1/RIPK3/MLKL signalling pathway in sepsis‐associated acute kidney injury

Experimental Physiology, EarlyView.
Abstract Sepsis‐associated acute kidney injury (SA‐AKI) is a common clinical syndrome in critically ill patients, and its high mortality rate is closely related to complex pathological mechanisms. Existing studies have shown that the pathophysiological process of SA‐AKI involves complex multi‐mechanism interactions, including an uncontrolled systemic ...
Huijun Yin, Jingyi Wang, Huirong Han
wiley   +1 more source

A sensitive interactome-based approach to characterize drug activity in living human cells. [PDF]

J Biol Chem
Kundlacz C, Forcet C, Sleiman NH, Vonau S, Marmigère F, Gillet B, Hughes S, Gilquin L, Duplus H, Dumont A, Yvert G, Bleicher F, Gautier A, Coste I, Renno T, Merabet S.   +15 more
europepmc   +1 more source

Muscle wasting in cancer cachexia: Mechanisms and the role of exercise

Experimental Physiology, EarlyView.
Abstract Cancer cachexia (CC) is a multifactorial disease marked by a severe and progressive loss of lean muscle mass and characterized further by inflammation and a negative energy/protein balance, ultimately leading to muscle atrophy and loss of muscle tissue.
Zoe P. Libramento, Louisa Tichy, Traci L. Parry   +2 more
wiley   +1 more source

The central function and specific molecular mechanisms of the TLR4 pathway underlying impaired intestinal barrier in necrotizing enterocolitis. [PDF]

Biochem Biophys Rep
Ren X, Su X, Arigong G.
europepmc   +1 more source

Warburg redefined: Metabolites, mitochondria and macrophages in immune regulation

The Journal of Physiology, EarlyView.
Abstract figure legend Following pro‐inflammatory stimulation, macrophages undergo Warburg‐like metabolic rewiring that extends more than increased glycolysis. The non‐canonical functions of glycolytic enzymes and lactate accumulation control macrophage immune responses through multiple signalling pathways (a).
Yukun Min, Órlaith C. Henry, Luke A. J. O'Neill   +2 more
wiley   +1 more source