Results 81 to 90 of about 188,742 (365)
Animal Models and Experimental Medicine, Volume 5, Issue 6, Page 557-564, December 2022., 2022 In the current study, after anesthetized rat with urethan the femoral artery was cannulated, then its head was mounted on a stereotaxic instrument and drugs (saline‐NAME, L‐Arg, and L_Arg+ L‐NAME) microinjected into the dmPAG and cardiovascular responses that recorded by a Power lab were evaluated.
Mohammad Najaftomaraei +5 more
wiley +1 more source
Areas of Convergence and Divergence in Adolescent Social Isolation and Binge Drinking: A Review
Frontiers in Behavioral Neuroscience, 2022 Adolescence is a critical developmental period characterized by enhanced social interactions, ongoing development of the frontal cortex and maturation of synaptic connections throughout the brain.
Jyoti Lodha +3 more
doaj +1 more source
Theory of Myelin Coiling [PDF]
, 2005 A new model is proposed to explain coiling of myelins composed of fluid bilayers. This model allows the constituent bilayer cylinders of a myelin to be non-coaxial and the bilayer lateral tension to vary from bilayer to bilayer. The calculations show that a myelin would bend or coil to lower its free energy when the bilayer lateral tension is ...
arxiv +1 more source
Phase 1, First‐In‐Human, Single‐/Multiple‐Ascending Dose Study of Iluzanebart in Healthy Volunteers
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of iluzanebart, a fully human monoclonal antibody TREM2 (triggering receptor expressed on myeloid cells 2) agonist, after single‐ (SAD) and multiple‐ascending‐dose (MAD) administration.
Andreas Meier +8 more
wiley +1 more source
Epitope Mapping of Anti‐Neurofascin 155 Antibody in a Large Cohort of Autoimmune Nodopathy Patients
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Autoimmune nodopathy (AN), a newly recognized disease entity, is an immune‐mediated polyneuropathy involving autoantibodies against cell adhesion molecules located in nodes of Ranvier and paranodal regions, such as neurofascin 186 (NF186) and neurofascin 155 (NF155). The present study aimed to identify the epitopes for autoantibodies
Amina A. Abdelhadi +6 more
wiley +1 more source
Neurotherapeutics, 2021 Myelin is a key evolutionary specialization and adaptation of vertebrates formed by the plasma membrane of glial cells, which insulate axons in the nervous system. Myelination not only allows rapid and efficient transmission of electric impulses in the axon by decreasing capacitance and increasing resistance but also influences axonal metabolism and ...
openaire +3 more sources
Derivation of cable equation by multiscale analysis for a model of myelinated axons [PDF]
arXiv, 2018 The paper concerns the multiscale modeling of a myelinated axon. Taking into account the microstructure with alternating myelinated parts and nodes Ranvier, we derive a nonlinear cable equation describing the potential propagation along the axon.
arxiv
Myelin Plasticity and Nervous System Function.
Annual Review of Neuroscience, 2018 Structural plasticity in the myelinated infrastructure of the nervous system has come to light. Although an innate program of myelin development proceeds independent of nervous system activity, a second mode of myelination exists in which activity ...
Michelle Monje
semanticscholar +1 more source
Advanced Functional Materials, EarlyView.This study introduces a conductive nerve guidance conduit integrated with wireless electrical stimulation through alternating magnetic fields, which induces currents and creates a supportive microenvironment for nerve regeneration. In vivo studies show that this approach significantly enhanced myelin restoration, gastrocnemius muscle regeneration ...
Shiheng Liu +7 more
wiley +1 more source
A physical perspective to understand myelin. II. The physical origin of myelin development [PDF]
arXiv, 2021 The physical principle of myelin development is obtained from our previous study by explaining Peter's quadrant mystery: an external applied negative and positive E-field can promote and inhibit the growth of the inner tongue of the myelin sheath, respectively. In this study, this principle is considered as a fundamental hypothesis, named Hypothesis-E,
arxiv