Results 81 to 90 of about 300,317 (388)

Myelin down-regulates myelin phagocytosis by microglia and macrophages through interactions between CD47 on myelin and SIRPα (signal regulatory protein-α) on phagocytes

Journal of Neuroinflammation, 2011
Background Traumatic injury to axons produces breakdown of axons and myelin at the site of the lesion and then further distal to this where Wallerian degeneration develops.
Reichert Fanny, Oldenborg Per-Arne, Liraz-Zaltsman Sigal, Gitik Miri, Rotshenker Shlomo   +4 more
doaj   +1 more source

Prolonged Environmental Enrichment Promotes Developmental Myelination

Frontiers in Cell and Developmental Biology, 2021
Postnatal neurodevelopment is profoundly influenced by environmental experiences. Environmental enrichment is a commonly used experimental paradigm that has uncovered numerous examples of experience-dependent plasticity in health and disease.
Evan Z. Goldstein, Vera Pertsovskaya, Thomas A. Forbes, Jeffrey L. Dupree, Vittorio Gallo   +4 more
doaj   +1 more source

Switching modes of myelination [PDF]

Nature Reviews Neuroscience, 2014
A new study shows that myelination may proceed in activity-dependent and -independent manners and that activity-dependent myelination is linked to neuregulin-induced signalling in oligodendrocytes, which makes these cells more sensitive to glutamate release.
openaire   +3 more sources

Differential binding patterns of anti-sulfatide antibodies to glial membranes [PDF]

, 2018
Sulfatide is a major glycosphingolipid in myelin and a target for autoantibodies in autoimmune neuropathies. However neuropathy disease models have not been widely established, in part because currently available monoclonal antibodies to sulfatide may ...
Barrie, Jennifer A., Cunningham, Madeleine E., Gourlay, Dawn, Halstead, Susan K., McGonigal, Rhona, Meehan, Gavin R., Wang, Yuzhong, Willison, Hugh J., Yao, Denggao   +8 more
core   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Anillin facilitates septin assembly to prevent pathological outfoldings of central nervous system myelin

eLife, 2019
Myelin serves as an axonal insulator that facilitates rapid nerve conduction along axons. By transmission electron microscopy, a healthy myelin sheath comprises compacted membrane layers spiraling around the cross-sectioned axon. Previously we identified
Michelle S Erwig, Julia Patzig, Anna M Steyer, Payam Dibaj, Mareike Heilmann, Ingo Heilmann, Ramona B Jung, Kathrin Kusch, Wiebke Möbius, Olaf Jahn, Klaus-Armin Nave, Hauke B Werner   +11 more
doaj   +1 more source

T Cells Actively Infiltrate the White Matter of the Aging Monkey Brain in Relation to Increased Microglial Reactivity and Cognitive Decline

Frontiers in Immunology, 2021
Normal aging is characterized by declines in processing speed, learning, memory, and executive function even in the absence of neurodegenerative diseases such as Alzheimer's Disease (AD). In normal aging monkeys and humans, neuronal loss does not account
Katelyn V. Batterman, Payton E. Cabrera, Tara L. Moore, Tara L. Moore, Tara L. Moore, Douglas L. Rosene, Douglas L. Rosene   +6 more
doaj   +1 more source

Demyelination and axonal preservation in a transgenic mouse model of Pelizaeus-Merzbacher disease [PDF]

, 2010
It is widely thought that demyelination contributes to the degeneration of axons and, in combination with acute inflammatory injury, is responsible for progressive axonal loss and persistent clinical disability in inflammatory demyelinating disease.
Angus M. Brown, Fredrik I. Gruenenfelder, Ian R. Griffiths, Julia M. Edgar, Klaus‐Armin Nave, Laura Pratola, Mailis C. McCulloch, Paul Montague, Sebastian Thilemann, Siegal S, Williams MA   +10 more
core   +2 more sources

Transcriptional regulation of neuropeptide receptors underlies context‐dependent adaptation in Drosophila melanogaster

FEBS Open Bio, EarlyView.
Under environmental changes, the expression level of neuropeptide (NP) and neuropeptide receptor (NPR) genes changes to confer context‐dependent adaptation to the model organism Drosophila melanogaster. Through finding more regulatory elements in the NPR genes in comparison with their ligands (NPs), we found that NPR‐biased transcriptional regulation ...
SeungHeui Ryu, Yanan Wei, Zekun Wu, Tianmu Zhang, DoHoon Lee, Hadi Najafi, Woo Jae Kim   +6 more
wiley   +1 more source

Dendropanax morbiferus leaf extract facilitates oligodendrocyte development [PDF]

Royal Society Open Science, 2019
Treatment of multiple sclerosis is effective when anti-inflammatory, neuroprotective and regenerative strategies are combined. Dendropanax morbiferus (DM) has anti-inflammatory, anti-oxidative properties, which may be beneficial for multiple sclerosis ...
Ji-Young Kim, Ju-Young Yoon, Yuki Sugiura, Soo-Kyoung Lee, Jae-Don Park, Gyun-Jee Song, Hyun-Jeong Yang   +6 more
doaj   +1 more source