Results 111 to 120 of about 212,147 (360)
Lethal adulthood myelin breakdown by oligodendrocyte-specific Ddx54 knockout
iScience, 2023 Summary: Multiple sclerosis (MS) is a leading disease that causes disability in young adults. We have previously shown that a DEAD-box RNA helicase Ddx54 binds to mRNA and protein isoforms of myelin basic protein (MBP) and that Ddx54 siRNA blocking ...
Hiroaki Oizumi +10 more
doaj
Peripheral nerve pathology in sickle cell disease mice
PAIN Reports, 2019 . Introduction:. Many patients with sickle cell disease (SCD) suffer from chronic pain, which is often described as neuropathic in nature. Although vascular and inflammatory pathology undoubtedly contribute to the SCD pain experience, the nociceptive ...
Katelyn E. Sadler +4 more
doaj +1 more source
Expert Perspective: Diagnosis and Treatment of Castleman Disease
Arthritis &Rheumatology, Accepted Article.Summary Castleman disease (CD) is a major diagnostic challenge for Rheumatologists. Unicentric CD (UCD) involves one enlarged lymph node region whereas multicentric CD (MCD) involves multiple enlarged lymph node regions. Both UCD and MCD may exhibit a wide range of symptoms that overlap with other immune‐mediated conditions.
Luke Y.C. Chen +2 more
wiley +1 more source
A novel model of demyelination and remyelination in a GFP-transgenic zebrafish
Biology Open, 2014 Demyelinating diseases consist of a variety of autoimmune conditions in which the myelin sheath is damaged due to genetic and/or environmental factors.
Yangwu Fang +7 more
doaj +1 more source
Axonal regeneration in hippocampal and spinal cord organotypic slice cultures [PDF]
, 2010 Under normal conditions, axonal regeneration after lesions is not possible in mature CNS but can occur in embryonic and early postnatal nervous systems. In recent years, a number of possible strategies to enhance axonal regeneration and eventually treat ...
Bonnici, Brenda
core +1 more source
Journal of Immunology, 1974 Homologous myelin basic protein has been used successfully for treatment of experimental allergic encephalomyelitis (EAE) in NIH and strain 13 guinea pigs.
B. Driscoll, M. Kies, E. Alvord
semanticscholar +1 more source
Deciphering the skeletal interoceptive circuitry to control bone homeostasis
BMEMat, EarlyView.This review introduces the skeletal interoceptive circuitry, covering the ascending signals from bone tissues to the brain (sensors), the central neural circuits that integrate this information and dispatch commands (CPU), and the descending pathways that regulate bone homeostasis (effectors).
Yefeng Wu +7 more
wiley +1 more source
Myelin basic protein peptide 45–89 induces the release of nitric oxide from microglial cells.
, 2002 Continuous (24 h) exposure of mixed oligodendrocyte/microglial cells to peptides 45–89 derived from citrullinated C8 isoforms of myelin basic protein (MBP) induces cell death.
Machaidze, G. +4 more
core
The multifaceted role of astrocytes in regulating myelination [PDF]
, 2016 Astrocytes are the major glial cell of the central nervous system (CNS), providing both metabolic and physical support to other neural cells. After injury, astrocytes become reactive and express a continuum of phenotypes which may be supportive or ...
Barnett, Susan C. +3 more
core +2 more sources
Metabolic instability of myelin proteins. Breakdown of basic protein induced by brain cathepsin D.
European Journal of Biochemistry, 1975 Myelin basic protein, purified from bovine spinal cord, is cleaved by a purified bovine brain acid proteinase to yield three peptide fragments which were purified by gel filtration procedures combined with preparative gel electrophoresis.
M. Benuck, N. Marks, G. Hashim
semanticscholar +1 more source