Results 271 to 280 of about 90,594 (330)
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Autoimmunity to Myelin Basic Protein
1982Experimental allergic encephalomyelitis (EAE) is an autoimmune central nervous system (CNS) disease which has been studied extensively, and has provided insight into mechanisms of immune tissue damage and immunologic self-tolerance. In addition, EAE serves as a prototype for human demyelinating diseases such as multiple sclerosis1.
R H, Swanborg, J H, Holda, J A, Killen
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1981
Myelin basic protein (MBP) has engaged the attention of molecular and cellular immunologists during the past decade because of its implication in the induction of the autoimmune disease experimental allergic encephalomyelitis (EAE) of the central nervous system (CNS).
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Myelin basic protein (MBP) has engaged the attention of molecular and cellular immunologists during the past decade because of its implication in the induction of the autoimmune disease experimental allergic encephalomyelitis (EAE) of the central nervous system (CNS).
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Matrix metalloproteinases degrade myelin basic protein
Neuroscience Letters, 1995Matrix metalloproteinases (MMPs) are a group of enzymes responsible for the degradation of interstitial connective tissue and basement membrane. The coding sequences for five of the human MMPs, viz. interstitial collagenase, 72 kDa gelatinase, stromelysin-1, matrilysin and 92 kDa gelatinase, were cloned and expressed in Chinese hamster ovary cells, and
S, Chandler +5 more
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Myelin basic protein: a multifunctional protein
Cellular and Molecular Life Sciences, 2006Myelin basic protein (MBP), the second most abundant protein in central nervous system myelin, is responsible for adhesion of the cytosolic surfaces of multilayered compact myelin. A member of the 'intrinsically disordered' or conformationally adaptable protein family, it also appears to have several other functions.
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Myelin basic protein depolarizes neuronal membranes
Neuroscience Letters, 1979Bath application of 10(-5) M myelin basic protein (MBP) to various types of cultured nerve cells resulted in a membrane depolarization amounting to a change of 41 +/- 15 mV. Excitability could be restored by repolarizing the membrane by means of current injection through the recording electrode.
B H, Gähwiler, C G, Honegger
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Enzyme-linked immunoadsorbent assays for myelin basic protein and antibodies to myelin basic protein
Biochemical Society Transactions, 1980Abstract: Enzyme Linked Immunoadsorbent Assays are described for Myelin Basic Protein and antibodies to this protein. Under optimal conditions 30 pg of Basic Protein and 100 pg of antibody can be detected. Both assays are simple to establish, require small volumes of sample, and are highly reproducible.
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1995
Myelin basic protein is a structural protein of the nervous system composed of three structural units joined by double phenylalanine residues. The central unit of this stucture — the B fragment — can be found free within the CSF in cases of demyelination or cerebral damage.
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Myelin basic protein is a structural protein of the nervous system composed of three structural units joined by double phenylalanine residues. The central unit of this stucture — the B fragment — can be found free within the CSF in cases of demyelination or cerebral damage.
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1974
Publisher Summary The A1 protein is a highly specialized protein that subserves its role as a structural protein of myelin, but in addition, provides a focus for immunopathological attack. It belongs to a class of membrane proteins with external location that are polar rather than nonpolar, nonglobular, and easily soluble in aqueous systems upon ...
E.H. Eylar, P.J. Kniskern, J.J. Jackson
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Publisher Summary The A1 protein is a highly specialized protein that subserves its role as a structural protein of myelin, but in addition, provides a focus for immunopathological attack. It belongs to a class of membrane proteins with external location that are polar rather than nonpolar, nonglobular, and easily soluble in aqueous systems upon ...
E.H. Eylar, P.J. Kniskern, J.J. Jackson
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Myelin basic protein interacts with the myelin-specific ganglioside GM4
Brain Research, 1981Demyelinated plaques in multiple sclerosis have decreased amounts of both myelin basic protein and sialosylgalactosylceramide (GM4), a ganglioside specifically localized in myelin and oligodendroglia of the central nervous system. We have found that myelin basic protein is capable of releasing large quantities of entrapped [14C]glucose from ...
B R, Mullin +3 more
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Immunochemical comparisons among myelin basic proteins
Comparative Biochemistry and Physiology Part B: Comparative Biochemistry, 19781. The relationships among myelin encephalitogenic or basic proteins were immunochemically examined. 2. Rabbit antisera to myelin basic proteins isolated from chicken, rabbit, bovine, guinea-pig, and human brain specimens were prepared. By quantitative microcomplement fixation these rabbit antisera were used to measure cross-reactions among the myelin ...
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