Results 281 to 290 of about 89,485 (332)
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1974
Publisher Summary The A1 protein is a highly specialized protein that subserves its role as a structural protein of myelin, but in addition, provides a focus for immunopathological attack. It belongs to a class of membrane proteins with external location that are polar rather than nonpolar, nonglobular, and easily soluble in aqueous systems upon ...
E.H. Eylar, P.J. Kniskern, J.J. Jackson
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Publisher Summary The A1 protein is a highly specialized protein that subserves its role as a structural protein of myelin, but in addition, provides a focus for immunopathological attack. It belongs to a class of membrane proteins with external location that are polar rather than nonpolar, nonglobular, and easily soluble in aqueous systems upon ...
E.H. Eylar, P.J. Kniskern, J.J. Jackson
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Myelin basic protein interacts with the myelin-specific ganglioside GM4
Brain Research, 1981Demyelinated plaques in multiple sclerosis have decreased amounts of both myelin basic protein and sialosylgalactosylceramide (GM4), a ganglioside specifically localized in myelin and oligodendroglia of the central nervous system. We have found that myelin basic protein is capable of releasing large quantities of entrapped [14C]glucose from ...
B R, Mullin +3 more
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Immunochemical comparisons among myelin basic proteins
Comparative Biochemistry and Physiology Part B: Comparative Biochemistry, 19781. The relationships among myelin encephalitogenic or basic proteins were immunochemically examined. 2. Rabbit antisera to myelin basic proteins isolated from chicken, rabbit, bovine, guinea-pig, and human brain specimens were prepared. By quantitative microcomplement fixation these rabbit antisera were used to measure cross-reactions among the myelin ...
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The distribution of myelin basic protein mRNAs within myelinating oligodendrocytes
Trends in Neurosciences, 1993The nervous system contains oligodendrocytes with processes that are greatly extended in space. It is now clear that there are numerous complex, poorly understood mechanisms by which polypeptides are synthesized and delivered to their sites of function in these cells.
P J, Brophy, G L, Boccaccio, D R, Colman
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Myelin basic protein and multiple sclerosis
The Italian Journal of Neurological Sciences, 1983Myelin basic protein (BP) has the capacity to induce experimental allergic encephalomyelitis (EAE) in animals as well as to prevent and suppress EAE. Immunoreactive BP or BP fragments appear in cerebrospinal fluid (CSF) in persons with multiple sclerosis in acute disease periods and in individuals with acute damage to central nervous system myelin ...
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MYELIN BASIC PROTEIN MICROHETEROGENEITY IN SUBFRACTIONS OF RAT BRAIN MYELIN
Journal of Neurochemistry, 1978Abstract— Myelin subfractions were prepared from adult rat brain by discontinuous sucrose gradient ultracentrifugation. Gel electrophoretic studies at pH 10.6 in the presence of urea revealed differences in basic protein microheterogeneity among subfractions.
C W, Shults, J N, Whitaker, J G, Wood
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Phosphorylation on basic amino acids in myelin basic protein
Biochemical and Biophysical Research Communications, 1976Abstract Isolated rat brain myelin when incubated with γ 32 P labelled ATP yields proteins bearing acid labile, base stable phosphoryl groups. Phosphorylated myelin basic protein can be isolated and degraded with trypsin and pronase to yield principally phosphoarginine and phosphohistidine.
L S, Smith +3 more
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Encephalitogenic Epitopes of Myelin Basic Protein
1989Etude des determinants antigeniques de la proteine basique myeline capable d'induire une encephalomyelite allergique.
R B, Fritz, D E, McFarlin
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Nuclear transport of myelin basic protein
Journal of Neuroscience Research, 1997The multiple myelin basic protein (MBP) isoforms expressed by myelinating cells are now known to have different expression patterns. The relative abundance of the isoforms containing exon II is greater early in myelinogenesis, whereas in compact myelin the isoforms lacking this exon are more abundant.
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Myelin Basic Protein and Demyelinating Diseases
CRC Critical Reviews in Clinical Laboratory Sciences, 1986Myelin basic protein (MBP) is a major protein component of myelin sheath. Primarily because of its ability to induce experimental allergic encephalomyelitis (EAE) in animals, this protein has been considered to play an important role in the pathogenesis of multiple sclerosis (MS), which is one of the most common demyelinating diseases.
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