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Scandinavian Journal of Immunology, 1982
Our attention was first directed to a study of myelin proteins because of our interest in the induction of experimental allergic encephalomyelitis (EAE) and the fact that Kabat et al. (11) and Morgan (26) had reported that white matter was more encephalitogenic than gray matter.
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Our attention was first directed to a study of myelin proteins because of our interest in the induction of experimental allergic encephalomyelitis (EAE) and the fact that Kabat et al. (11) and Morgan (26) had reported that white matter was more encephalitogenic than gray matter.
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Myelin breakdown and basic protein
Experimental Neurology, 1974Abstract The purpose of the present work was to study the mechanisms of myelin breakdown in experimental conditions and the fate of protein components in myelin, especially that of myelin basic protein which is known to be important in demyelinative disorders. The results showed that when myelin was incubated alone without any added enzymes there was
M, Röyttä +4 more
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Autoimmunity to Myelin Basic Protein
1982Experimental allergic encephalomyelitis (EAE) is an autoimmune central nervous system (CNS) disease which has been studied extensively, and has provided insight into mechanisms of immune tissue damage and immunologic self-tolerance. In addition, EAE serves as a prototype for human demyelinating diseases such as multiple sclerosis1.
R H, Swanborg, J H, Holda, J A, Killen
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1981
Myelin basic protein (MBP) has engaged the attention of molecular and cellular immunologists during the past decade because of its implication in the induction of the autoimmune disease experimental allergic encephalomyelitis (EAE) of the central nervous system (CNS).
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Myelin basic protein (MBP) has engaged the attention of molecular and cellular immunologists during the past decade because of its implication in the induction of the autoimmune disease experimental allergic encephalomyelitis (EAE) of the central nervous system (CNS).
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Matrix metalloproteinases degrade myelin basic protein
Neuroscience Letters, 1995Matrix metalloproteinases (MMPs) are a group of enzymes responsible for the degradation of interstitial connective tissue and basement membrane. The coding sequences for five of the human MMPs, viz. interstitial collagenase, 72 kDa gelatinase, stromelysin-1, matrilysin and 92 kDa gelatinase, were cloned and expressed in Chinese hamster ovary cells, and
S, Chandler +5 more
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Myelin basic protein: a multifunctional protein
Cellular and Molecular Life Sciences, 2006Myelin basic protein (MBP), the second most abundant protein in central nervous system myelin, is responsible for adhesion of the cytosolic surfaces of multilayered compact myelin. A member of the 'intrinsically disordered' or conformationally adaptable protein family, it also appears to have several other functions.
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Myelin basic protein depolarizes neuronal membranes
Neuroscience Letters, 1979Bath application of 10(-5) M myelin basic protein (MBP) to various types of cultured nerve cells resulted in a membrane depolarization amounting to a change of 41 +/- 15 mV. Excitability could be restored by repolarizing the membrane by means of current injection through the recording electrode.
B H, Gähwiler, C G, Honegger
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Enzyme-linked immunoadsorbent assays for myelin basic protein and antibodies to myelin basic protein
Biochemical Society Transactions, 1980Abstract: Enzyme Linked Immunoadsorbent Assays are described for Myelin Basic Protein and antibodies to this protein. Under optimal conditions 30 pg of Basic Protein and 100 pg of antibody can be detected. Both assays are simple to establish, require small volumes of sample, and are highly reproducible.
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1995
Myelin basic protein is a structural protein of the nervous system composed of three structural units joined by double phenylalanine residues. The central unit of this stucture — the B fragment — can be found free within the CSF in cases of demyelination or cerebral damage.
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Myelin basic protein is a structural protein of the nervous system composed of three structural units joined by double phenylalanine residues. The central unit of this stucture — the B fragment — can be found free within the CSF in cases of demyelination or cerebral damage.
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