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Autoimmunity to Myelin Basic Protein
1982Experimental allergic encephalomyelitis (EAE) is an autoimmune central nervous system (CNS) disease which has been studied extensively, and has provided insight into mechanisms of immune tissue damage and immunologic self-tolerance. In addition, EAE serves as a prototype for human demyelinating diseases such as multiple sclerosis1.
Joyce A. Killen +2 more
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Quantitation of myelination and demyelination by the measurement of myelin basic protein by ELISA
Journal of the Neurological Sciences, 1986Utilizing a competitive inhibition enzyme-linked immunosorbent assay (ELISA) we measured the amount of myelin basic protein (MBP) in brain, liver, and kidney of newborn mouse and compared these values with myelinated cerebellar explant cultures under various conditions.
J. Wang +4 more
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Myelin breakdown and basic protein
Experimental Neurology, 1974Abstract The purpose of the present work was to study the mechanisms of myelin breakdown in experimental conditions and the fate of protein components in myelin, especially that of myelin basic protein which is known to be important in demyelinative disorders. The results showed that when myelin was incubated alone without any added enzymes there was
Matias Röyttä +4 more
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1981
Myelin basic protein (MBP) has engaged the attention of molecular and cellular immunologists during the past decade because of its implication in the induction of the autoimmune disease experimental allergic encephalomyelitis (EAE) of the central nervous system (CNS).
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Myelin basic protein (MBP) has engaged the attention of molecular and cellular immunologists during the past decade because of its implication in the induction of the autoimmune disease experimental allergic encephalomyelitis (EAE) of the central nervous system (CNS).
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Crystallization of P2 myelin protein
Journal of Molecular Biology, 1987Single crystals of bovine P2 myelin protein have been grown in polyethylene glycol 4000 by the hanging-drop vapor diffusion method. Crystals belonging to space group P2(1)2(1)2(1) with cell dimensions a = 91.8 A, b = 99.5 A, c = 56.5 A (1 A = 0.1 nm). The diffraction pattern extends to better than 2.3 A resolution.
Torsten Unge +5 more
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Current Medicinal Chemistry, 2005
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS) characterized by demyelination and loss of neurological function, local macrophage infiltrate and neuroantigen-specific CD4(+)T cells.
A. Tzakos +7 more
semanticscholar +1 more source
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS) characterized by demyelination and loss of neurological function, local macrophage infiltrate and neuroantigen-specific CD4(+)T cells.
A. Tzakos +7 more
semanticscholar +1 more source
Turnover of proteins in myelin and myelin-like material of mouse brain
Brain Research, 1974Abstract Mice 14 or 60 days of age were injected intraperitoneally with [3H]leucine and were decapitated 10, 20, 40, and 80 days later. A crude fraction of brain myelin was isolated on a discontinuous sucrose gradient. Myelin was separated from the associated myelin-like material by osmotic shock and the two fractions were purified by differential ...
Carolyn A. Fischer +3 more
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The turnover of myelin proteins in adult rat brain.
International Journal of Neuroscience, 1979The turnover of proteins of myelin of brain was followed after an intracerebral injections of [1-14C] leucine into adult rats and compared with the turnover of proteins of total brain homogenate, microsomal and supernatant fractions.
H. Singh, F. Jungalwala
semanticscholar +1 more source
Myelin basic protein interacts with the myelin-specific ganglioside GM4
Brain Research, 1981Demyelinated plaques in multiple sclerosis have decreased amounts of both myelin basic protein and sialosylgalactosylceramide (GM4), a ganglioside specifically localized in myelin and oligodendroglia of the central nervous system. We have found that myelin basic protein is capable of releasing large quantities of entrapped [14C]glucose from ...
Francis X. Decandis +3 more
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Myelin basic protein: a multifunctional protein
Cellular and Molecular Life Sciences, 2006Myelin basic protein (MBP), the second most abundant protein in central nervous system myelin, is responsible for adhesion of the cytosolic surfaces of multilayered compact myelin. A member of the 'intrinsically disordered' or conformationally adaptable protein family, it also appears to have several other functions.
Joan M. Boggs, Joan M. Boggs
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