Results 341 to 350 of about 5,673,942 (403)

Intrinsic myelin proteins are normally synthesized in vitro in the myelin-deficient (mld) mutant mouse.

Developmental Neuroscience, 1983
The synthesis of myelin basic protein is severely reduced in the central and peripheral nervous system of myelin-deficient (mld) mutant mice. Using an in vitro system and immunoprecipitation, we found a normal rate of synthesis in mld mice for two ...
J. Matthieu, G. Almazan, T. Waehneldt
semanticscholar   +1 more source

Myelin‐specific proteolipid protein is expressed in myelinating schwann cells but is not incorporated into myelin sheaths

Journal of Neuroscience Research, 1987
AbstractContrary to widely held beliefs, the gene encoding proteolipid protein (PLP), the major structural protein of central nervous system myelin, is ecpressed in Schwann cells and their tumors. Proteolipid mRNA was identified in human acoustic neuromas and in rat and rabbit sciatic nerves using a human PLP cDNA as probe.
Lynn D. Hudson, Monique Dubois-Dalcq, K Ono, Robert A. Lazzarini, C Puckett, V Friedrich, J Benecke   +6 more
openaire   +3 more sources

Partial deficiencies in the myelin proteins of developing mice heterozygous for the shiverer mutation.

, 1982
The central nervous system of the shiverer mouse is known to be severely deficient in myelin. Animals heterozygous for this autosomal-recessive mutation were crossed, and the myelin proteins were examined in the brains and spinal cords of shiverers and ...
W. Cammer
semanticscholar   +1 more source

Many facets of the peripheral myelin protein PMP22 in myelination and disease

Microscopy Research and Technique, 1998
Peripheral myelin protein 22 (PMP22) is a small, hydrophobic glycoprotein, which is most prominently expressed by Schwann cells as a component of compact myelin of the peripheral nervous system (PNS). Recent progress in molecular genetics revealed that mutations affecting the PMP22 gene including duplications, deletions, and point mutations are ...
Ueli Suter, Roland Naef
openaire   +3 more sources

Myelin Enzymes and Protein Metabolism

1972
Turnover of myelin has attracted interest in relation to clinical and experimental diseases involving demyelination (7, 11). In adult rats, myelin represents about 12 % of total fresh weight, of which some 25 % is protein (14) and earlier concepts for its relative inertness are difficult to reconcile with the known halflife of under 20 days for 90 % of
openaire   +3 more sources

Conformation of Myelin Basic Protein and Its Role in Myelin Formation

1978
High resolution 13C and 1H NMR spectra of myelin basic protein over a range of pH and concentrations indicate that intramolecular folding of the polypeptide chain occurs in aqueous solution in the region of residues 85 to 116. At pH 4 in D2O solution, the 13C resonances due to nonprotonated carbons of phenylalanine and tryptophan are broadened and ...
B. E. Chapman, W. J. Moore, L. T. Littlemore   +2 more
openaire   +3 more sources

From Myelin Basic Protein to Myelin Deficient Mice

1990
In order to control diseases affecting myelination, an understanding of normal myelin structure and its formation is essential. Paradoxically, much information about normal development can be obtained through investigations of hypomyelinated mutants.
J.-M. Matthieu, M. Tosic
openaire   +2 more sources

Multiple sclerosis: Serum-derived exosomes express myelin proteins

Multiple Sclerosis, 2018
G. Galazka, M. Mycko, I. Selmaj, C. Raine, K. Selmaj   +4 more
semanticscholar   +1 more source

Comparison of CNS and PNS myelin proteins in the pathology of myelin disorders

Journal of the Neurological Sciences, 2005
This brief overview summarizes some of the ways that the structure, location and function of proteins in myelin sheaths affect the pathological abnormalities brought on by immunological, viral, genetic or other insults occurring in myelin disorders.
openaire   +3 more sources

Myelin basic protein

Biochemical Society Transactions, 1980
Martin G. Rumsby, Andrew G. Walker
openaire   +3 more sources