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Loss of Myelin Basic Protein Function Triggers Myelin Breakdown in Models of Demyelinating Diseases
Cell Reports, 2016 Breakdown of myelin sheaths is a pathological hallmark of several autoimmune diseases of the nervous system. We employed autoantibody-mediated animal models of demyelinating diseases, including a rat model of neuromyelitis optica (NMO), to target myelin ...
Marie-Theres Weil +13 more
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Myelin organization in the nodal, paranodal, and juxtaparanodal regions revealed by scanning x-ray microdiffraction. [PDF]
PLoS ONE, 2014 X-ray diffraction has provided extensive information about the arrangement of lipids and proteins in multilamellar myelin. This information has been limited to the abundant inter-nodal regions of the sheath because these regions dominate the scattering ...
Hideyo Inouye +6 more
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Methods and Protocols, 2022 A co-culture of neurons and Schwann cells has frequently been used to investigate myelin sheath formation. However, this approach is restricted to myelin-related diseases of the peripheral nervous system.
Yun Jeong Mo +3 more
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Neuroinflammation and myelin status in Alzheimer’s disease, Parkinson’s disease, and normal aging brains: A small sample study [PDF]
, 2019 Microglia and astrocytes play important roles in mediating the immune processes and nutritional support in the central nervous system (CNS). Neuroinflammation has been indicated in the progression of neurodegenerative diseases Alzheimer’s disease (AD ...
Benzinger, Tammie L. S. +7 more
core +2 more sources
MAGEA6 Engages a YY1‐Dependent Transcription to Dictate Perineural Invasion in Colorectal Cancer
Advanced Science, EarlyView.This study investigates the role of MAGEA6 in perineural invasion (PNI) in colorectal cancer (CRC). MAGEA6 promotes CRC invasiveness by inhibiting YY1 ubiquitination, enhancing CXCL1 secretion, and recruiting Schwann cells. These findings highlight the potential of targeting the MAGEA6/YY1/CXCL1 axis for therapeutic strategies against PNI and tumor ...
Hao Wang +9 more
wiley +1 more source
C1q is essential for myelination in the central nervous system (CNS)
iScience, 2023 Summary: Myelin sheath in the central nervous system (CNS) is essential for efficient action potential conduction. Microglia, the macrophages in the CNS, are suggested to regulate myelin development.
Qiang Yu +6 more
doaj
Di-san junyi daxue xuebao, 2020 Objective To explore the mechanisms by which Dexras1 promotes inflammation and participates in white matter damage (WMD) after subarachnoid hemorrhage (SAH). Methods Ninety healthy adult male SD rats were randomly divided into control group (sham group),
XIN Yuanjun +7 more
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Neural Regeneration Research, 2023 The extracellular matrix surrounding oligodendrocytes plays an important role during myelination and remyelination in the brain. In many cases, the microenvironment surrounding demyelination lesions contains inhibitory molecules, which lead to repair ...
Ya-Jie Xiong +5 more
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Correlated disorder in myelinated axons orientational geometry and structure
, 2017 While the ultrastructure of the myelin has been considered to be a quasi-crystalline stable system, nowadays its multiscale complex dynamics appears to play a key role for its functionality, degeneration and repair processes following neurological ...
Bianconi, Antonio +3 more
core +1 more source
Fiber orientation-dependent white matter contrast in gradient echo MRI [PDF]
, 2012 Recent studies have shown that there is a direct link between the orientation of the nerve fibers in white matter (WM) and the contrast observed in magnitude and phase images acquired using gradient echo MRI.
Behrens +23 more
core +2 more sources