Results 101 to 110 of about 53,780 (245)

Lysosome Evanescence Mediates Autophagic Flux Impairment in Glucose Imbalanced Environments

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Schwann cells (SCs) support axonal function and promote nerve regeneration. This study investigated how various glucose concentrations influence SC viability, oxidative stress, and autophagy, which contribute to diabetic neuropathy. RSC96 SCs were cultured under five glucose conditions (0, 2.5, 5.5, 50, or 100 mM) for 24, 48, and 72 h.
Yuan‐Chen Cheng, Ling‐Li Chang, Hung‐Chen Wang, Wei‐Chun Hung, Chia‐Hua Hsieh, Yi‐Hsuan Wang, Kuang‐I Cheng   +6 more
wiley   +1 more source

Combination Therapy With Fingolimod and Neural Stem Cells Promotes Functional Myelination [PDF]

, 2019
Myelination, which occurs predominantly postnatally and continues throughout life, is important for proper neurologic function of the mammalian central nervous system (CNS).
Ciric, Bogoljub, Li, Xing, Lu, Xin-Yu, Ma, Cun-Gen, Rostami, A. M., Ye, Ze-Qin, Zhang, Guang-Xian, Zhang, Yuan   +7 more
core   +1 more source

Restoration of SMN in Schwann cells reverses myelination defects and improves neuromuscular function in spinal muscular atrophy [PDF]

, 2016
Spinal muscular atrophy (SMA) is a neuromuscular disease caused by low levels of SMN protein, primarily affecting lower motor neurons. Recent evidence from SMA and related conditions suggests that glial cells can influence disease severity.
Brophy, Peter J., Gillingwater, Thomas H., Groen, Ewout J.N., Hunter, Gillian, Jones, Ross A., Lane, Fiona M., Powis, Rachael A., Sherman, Diane L., Shorrock, Hannah K., Zheng, Yinan   +9 more
core   +3 more sources

Mesna in Otologic Surgery: Efficacy and Safety—A Scoping Review

The Laryngoscope, EarlyView.
PRISMA flow diagram indicating the process of systematic inclusion and exclusion of articles. ABSTRACT Objective Mesna (Sodium 2‐mercaptoethanesulfonate) is widely used as a mucolytic agent and uroprotective agent. Recently, its disulfide bond‐breaking property has been applied in otologic surgery to facilitate safer dissection of cholesteatoma and ...
Kevork H. Atamian, Inabat Yermesheva, Ostap Orishchak, Hady Tall, Sam J. Daniel   +4 more
wiley   +1 more source

Entangled biphoton generation in the myelin sheath

Physical Review E
Consciousness within the brain hinges on the synchronized activities of millions of neurons, but the mechanism responsible for orchestrating such synchronization remains elusive. In this study, we employ cavity quantum electrodynamics (cQED) to explore entangled biphoton generation through cascade emission in the vibration spectrum of C-H bonds within ...
Zefei Liu, Yong-Cong Chen, Ping Ao
openaire   +3 more sources

Diabetic Peripheral Neuropathy: Molecular Staging, Risk Factors, Therapeutics, and Emerging Trends

Med Research, EarlyView.
The heterogeneous landscape of DPN can be unified through a tripartite pathogenic model encompassing progressive stages of metabolic dysregulation, chronic inflammation, and overt neuronal damage. Within this framework, six clinical subtypes were identified, namely, hyperglycemia‐driven, dyslipidemia‐driven, inflammation‐driven, dysvascularity‐driven ...
Xiaofeng Dai, Mingze Tang
wiley   +1 more source

Mesoscale Whole‐Brain T2*‐Weighted and Associated Quantitative MRI in Humans at 10.5 T

Magnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose To demonstrate mesoscale whole‐brain T2*‐weighted (T2*w) MRI at 10.5 T, quantify R2* relaxation rate and magnetic susceptibility (χ), and evaluate T2*w contrast at such high field strength. Methods Multi‐echo GRE (ME‐GRE) data were collected in healthy adults at 0.5 mm isotropic resolution at 10.5 T.
Jiaen Liu, Peter van Gelderen, Jacco A. de Zwart, Jeff H. Duyn, Yujia Huang, Shuxian Qu, Andrea Grant, Edward J. Auerbach, Matt Waks, Russell L. Lagore, Lance Delabarre, Alireza Sadeghi‐Tarakameh, Yigitcan Eryaman, Gregor Adriany, Kamil Uğurbil, Xiaoping Wu   +15 more
wiley   +1 more source

Modeling of Fiber Orientation‐Dependent R1 Relaxation in Human White Matter In Vivo Within The Framework of The Transient Hydrogen Bond Model

Magnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose Axon fiber orientation‐dependent R1 relaxation in human white matter (WM) in vivo at B0 = 1.5 T, 3 T, and 7 T was studied within the framework of the transient hydrogen bond (THB) model, which attributes MR signal relaxation to quantum magnetization interactions of water and motion‐restricted protons in hydrophilic heads of lipid ...
Dmitriy A. Yablonskiy, Risto A. Kauppinen, Ekaterina Paasonen, Jeromy Thotland, Mervi Könönen, Pramod Pisharady, Christophe Lenglet, Juhana M. Hakumäki, Olli H. J. Gröhn, Michael Garwood, Alexander L. Sukstanskii   +10 more
wiley   +1 more source

Studies on cultured Schwann cells: the induction of myelin synthesis, and the control of their proliferation by a new growth factor [PDF]

, 1981
We have recently described the use of immunological methods to identify and purify rat Schwann cells. In dissociated cultures of neonatal sciatic nerve, all of the cells can be identified by antigenic criteria as either Schwann cells or fibroblasts.
Brockes, J. P., Fryxell, K. J., Lemke, G. E.   +2 more
core  

Investigating the Sensitivity of the Diffusion MRI Signal to Magnetization Transfer and Permeability via Monte‐Carlo Simulations

Magnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose Magnetization transfer (MT) and water exchange via permeability operate on a similar spatiotemporal scale to water diffusion. In this study, we use a simulation‐based approach to characterize how MT and permeability impact (1) diffusion‐weighted MRI (dMRI) measurements from cylindrical substrates and (2) parameter estimation using a ...
Zhiyu Zheng, Karla L. Miller, Benjamin C. Tendler, Michiel Cottaar   +3 more
wiley   +1 more source