RXR Gamma Enables Oligodendrocyte Differentiation by Suppressing Sonic Hedgehog Signaling
Glia, Volume 74, Issue 6, June 2026.Using pharmacogenetic approaches, Baldassarro et al. demonstrate that RXRγ suppresses the SHH signaling pathway in OPCs to ensure their efficient differentiation following T3 stimulation. Accordingly, Rxrg−/− OPCs displayed compromised differentiation which was normalized by the pharmacological inhibition of the hyperactive SHH pathway.
Vito Antonio Baldassarro +4 more
wiley +1 more source
Regeneration of sensory nerve branches in extraction socket and surrounding alveolar bone in rat: immunohistochemical observation of the axon and myelin sheath changes. [PDF]
Odontology, 2023 Kakuta W +6 more
europepmc +1 more source
Developmental Profiling of Structural and Functional Maturation in Mouse Corpus Callosum
Glia, Volume 74, Issue 6, June 2026.Progressive myelin development in mouse corpus callosum is accompanied by gradual decrease in oligodendrocyte precursor cell density and increase in oligodendrocyte density. Pro‐Capase‐3 is transiently upregulated in oligodendrocyte during postnatal development.
Hayes Johnson +4 more
wiley +1 more source
A new diagnostic sampling method in pure neural leprosy: the scraping of the myelin sheath. [PDF]
An Bras Dermatol, 2021 Trave I +3 more
europepmc +1 more source
Glia, Volume 74, Issue 6, June 2026.Distinct microglial subpopulations are depicted, highlighting variations in gene expression and functional roles in response to specific disease conditions and the complexity of microglial activation and differentiation in neurodegeneration. ABSTRACT Microglial cells are key players in maintaining brain homeostasis and responding to pathological ...
Alessandro Palma +6 more
wiley +1 more source
The Akt-mTOR Pathway Drives Myelin Sheath Growth by Regulating Cap-Dependent Translation. [PDF]
J Neurosci, 2021 Fedder-Semmes KN, Appel B.
europepmc +1 more source
Lifespan Trajectories of Asymmetry in White Matter Tracts
Human Brain Mapping, Volume 47, Issue 8, June 1, 2026.(A) Large‐scale lifespan modeling of white matter asymmetry. Diffusion MRI data from 35,000+ individuals (0‐100 years) across 50 cohorts were used to generate normative lifespan trajectories of white matter asymmetry. Thirty bilateral tracts were segmented, and microstructural (FA, MD, AD, RD) and macrostructural (volume, length) features were ...
Sam Bogdanov +72 more
wiley +1 more source
Journal of Extracellular Vesicles, Volume 15, Issue 6, June 2026.Schematic illustration on a therapeutic strategy wherein engineered extracellular vesicles (EVs) are delivered intranasally and specifically target pericytes. In a model of chronic cerebral hypoperfusion (BCAS), this targeted approach preserves cerebral blood flow, reinforces blood‐brain barrier (BBB) integrity, stabilizes the neurovascular unit (NVU),
Weiwei Shen +11 more
wiley +1 more source
Development of the myelin sheath of the hypogastric nerves in a human foetus aged 23 weeks
, 2004 The formation of the myelin sheath of the human hypogastric nerves was studied by electron microscopy in a foetus of 23 weeks of postovulatory age (220 mm C-R length).
Bruska, M; Department of Anatomy, University School of Medical Sciences, Poznań, Poland +1 more
core
Biological Drivers of IMiD‐Induced Peripheral Neuropathy in Multiple Myeloma
eJHaem, Volume 7, Issue 3, June 2026.ABSTRACT The introduction of immunomodulatory drugs (IMiDs), such as thalidomide, lenalidomide and pomalidomide, have led to significant improvements in multiple myeloma (MM) treatment. Many patients now live 10 years or longer with their disease, making treatment‐related side effects increasingly important.
Sina A. Beer +2 more
wiley +1 more source