Results 181 to 190 of about 53,137 (327)

Nonvesicular lipid transfer drives myelin growth in the central nervous system

Nature Communications
Oligodendrocytes extend numerous cellular processes that wrap multiple times around axons to generate lipid-rich myelin sheaths. Myelin biogenesis requires an enormously productive biosynthetic machinery for generating and delivering these large amounts ...
Jianping Wu, Georg Kislinger, Jerome Duschek, Ayşe Damla Durmaz, Benedikt Wefers, Ruoqing Feng, Karsten Nalbach, Wolfgang Wurst, Christian Behrends, Martina Schifferer, Mikael Simons   +10 more
doaj   +1 more source

Synaptic ultrastructural alterations in human focal cortical dysplasia: Insights from volume electron microscopy

Epilepsia, EarlyView.
Abstract Objective Focal cortical dysplasia (FCD) is a developmental malformation of the cerebral cortex and a leading cause of drug‐resistant epilepsy in children and young adults. Disruption of the excitation–inhibition (E–I) balance is a hallmark of neuronal hyperexcitability in FCD, yet the underlying synaptic ultrastructural changes remain poorly ...
Gyu Hyun Kim, Na‐Young Seo, Seung‐Ki Kim, Jae‐Kyung Won, Yang Hoon Huh, Ji Yeoun Lee, Kea Joo Lee   +6 more
wiley   +1 more source

Olig2‐specific loss‐of‐function Slc35a2 results in hypomyelination and spontaneous seizures

Epilepsia, EarlyView.
Abstract Objective Malformations of cortical development represent major causes of drug‐resistant epilepsy, with mild malformation of cortical development with oligodendroglial hyperplasia and epilepsy recognized as a distinct pathological entity. Pathogenic X‐linked SLC35A2, encoding the uridine diphosphate–galactose transporter, has been implicated ...
Tiffany M. Bartel, Chaitali Ghosh, Kathryn Bisaha, Jean Khoury, Ashley Nemes‐Baran, Ingmar Blumcke, Imad Najm   +6 more
wiley   +1 more source

Myelin sheaths: glycoproteins involved in their formation, maintenance and degeneration

, 2002
Richard H. Quarles
openalex   +2 more sources

Acute neurologic presentation of a 2‐year‐old standardbred colt with multicentric diffuse large B cell lymphoma

Equine Veterinary Education, EarlyView.
Summary Lymphoma in horses is uncommon and rarely diagnosed as a cause of ataxia. This case report describes a 2‐year‐old Standardbred cryptorchid colt who presented with acute onset of grade 3–4/5 spinal ataxia in all four limbs, with the hindlimbs more severely affected than forelimbs and severe proprioceptive deficits.
K. MacMillan, J. Burns, E. John, M. Buote   +3 more
wiley   +1 more source

Knockdown of G protein-coupled receptor-17 (GPR17) facilitates the regeneration and repair of myelin sheath post-periventricular leukomalacia (PVL). [PDF]

Bioengineered, 2021
He L, Yang H, Feng J, Wei T, Huang Y, Zhang X, Wang Z.   +6 more
europepmc   +1 more source

The impact of early-life stress on the expression of genes associated with the formation of the myelin sheath of neurons in the prefrontal cortex of 15-day-old male mice

, 2020

openalex   +1 more source

Motor pathway evaluation by transcranial magnetic stimulation in Swedish horses with acquired equine polyneuropathy

Equine Veterinary Journal, EarlyView.
Abstract Background Acquired equine polyneuropathy in Nordic horses (AEP) is the most prevalent equine polyneuropathy in Norway, Sweden, and Finland and is characterised by pelvic limb knuckling due to metatarsophalangeal extension dysfunction.
Anna May, Siv Hanche‐Olsen, Lutz S. Goehring, Kaspar Matiasek, Karin Hultin Jäderlund, Yury Zablotski, Gittan Gröndahl   +6 more
wiley   +1 more source

Cone beam computed tomographic myelography in horses with cervical vertebral compressive myelopathy

Equine Veterinary Journal, EarlyView.
Abstract Background While computed tomographic (CT) myelography is increasingly available and has been evaluated in alive horses, objective criteria for diagnosing cervical vertebral compressive myelopathy (CVCM) are lacking. Objectives To establish morphometric dimensions of the cervical vertebral canal and spinal cords from horses with CVCM and ...
Sonia González‐Medina, Myra F. Barrett, Tawfik A. Aboellail, Bradley B. Nelson, Yvette S. Nout‐Lomas   +4 more
wiley   +1 more source

Distinct T Cell Receptor Clonotypes in the Sardinian Population Highlight the Role of Mucosal‐Associated Invariant T Cells and Invariant Natural Killer T Cells in Multiple Sclerosis

Immunology, EarlyView.
Antigen‐specific TCR‐α clonotype frequencies in MS and HC groups. (A) Heatmap of CDR3 TCR‐α clonotype annotations. (B) Comparative analysis of CDR3 TCR‐α clonotypes targeting viral and autoimmune‐related antigens, including VP22, p65, NS4B, MLANA, M1, HA and BST2. NS3‐HCV‐specific CDR3 clonotypes are significantly enriched in MS patients.
Jiaxin Shen, Elena Rita Simula, Yisu Liu, Gustavo Sganzerla Martinez, Xiaofen Wen, David J. Kelvin, Leonardo A. Sechi   +6 more
wiley   +1 more source