Results 181 to 190 of about 48,712 (325)

Improved UNet‐based magnetic resonance imaging segmentation of demyelinating diseases with small lesion regions

Cognitive Computation and Systems, EarlyView.
Abstract Accurate magnetic resonance imaging (MRI) segmentation plays a critical role in the diagnosis and treatment of demyelinating diseases. But the existing automatic segmentation methods are not suitable for the segmentation of demyelinating lesions with small lesion size, highly diffuse edges and complex boundary shapes.
Minhui Liu, Tianlei Wang, Dekang Liu, Feng Gao, Jiuwen Cao   +4 more
wiley   +1 more source

Microglial States Are Susceptible to Senescence and Cholesterol Dysregulation in Alzheimer's Disease

Aging Cell, EarlyView.
Senescent microglia in Alzheimer's disease exhibit dysregulated cholesterol metabolism and express Disease‐Associated Microglia (DAM) signatures, including inflammatory and phagocytic markers. Single‐nucleus RNA‐seq from human brain tissues identified cholesterol‐related senescence gene co‐expression modules linked to microglial senescence.
Boyang Li, Shaowei Wang, Bilal Kerman, Cristelle Hugo, E. Keats Shwab, Chang Shu, Ornit Chiba‐Falek, Zoe Arvanitakis, Hussein N. Yassine   +8 more
wiley   +1 more source

The physiological and pathological effects of sphingolipid metabolism and signaling in the central nervous system

Brain Pathology, EarlyView.
Sphingolipids are vital components of cell membranes. Metabolic disruptions of sphingolipids, including ceramide and sphingosine‐1‐phosphate, are linked to neurological disorders. This article summarizes the classification, structure, and metabolic processes of sphingolipids, and the physiological and pathological effects of sphingolipid metabolism and
Tian Li, Haoying He, Ejuan Zhang, Fengjiao Hu, Zhuo Wang, Jian Xu, Mengliu Zeng, Biwen Peng   +7 more
wiley   +1 more source

Myelin sheaths: glycoproteins involved in their formation, maintenance and degeneration

, 2002
Richard H. Quarles
openalex   +2 more sources

Synthetic microneurotrophins: Neurotrophin receptors for therapeutics of neurodegenerative diseases

British Journal of Pharmacology, EarlyView.
Neurodegenerative disorders are characterised by the chronic progressive degeneration of specific neuronal subtypes, neuroinflammation, myelin damage and synaptic loss. Despite their growing incidence, advancements in effective treatments remain limited, because of lack of knowledge for the aetiology of the diverse pathophysiology to design systematic ...
Ioanna Zota, Theodora Calogeropoulou, Konstantina Chanoumidou, Ioannis Charalampopoulos, Achille Gravanis   +4 more
wiley   +1 more source

The impact of early-life stress on the expression of genes associated with the formation of the myelin sheath of neurons in the prefrontal cortex of 15-day-old male mice

, 2020

openalex   +1 more source

Beyond synapses: cytoplasmic connections in brain function and evolution

Biological Reviews, EarlyView.
ABSTRACT Following Ramón y Cajal's groundbreaking contributions to the identification of synapses, research in neuroscience predominantly focused on their pivotal role in neural communication (the neuron doctrine), overlooking an intriguing possibility suggested by Golgi of non‐synaptic interactions among neural cells.
Malalaniaina Rakotobe, Chiara Zurzolo
wiley   +1 more source

Proteomic Profiling of Cerebrum Mitochondria, Myelin Sheath, and Synaptosome Revealed Mitochondrial Damage and Synaptic Impairments in Association with 3 × Tg-AD Mice Model. [PDF]

Cell Mol Neurobiol, 2022
Shen L, Yang A, Chen X, Xiao S, Liu X, Lin J, Zhao Y, Zhang K, Li C, Ke J, Zhang H, Khan NU.   +11 more
europepmc   +1 more source

Tumor‐related epilepsy in glioma: A multidisciplinary overview

Epilepsia, EarlyView.
Abstract Seizures are a common and challenging symptom in brain tumors, affecting approximately 60% of patients. Tumor‐related epilepsy (TRE) in glioma patients requires personalized and dynamic management in a multidisciplinary environment, especially for its intricate pathophysiology and unpredictable disease evolution. This investigation provides an
Roberto Michelucci, Giada Pauletto, Antonio Silvani, Elena Pasini, Tamara Ius, Matteo Martinoni, Carlo Alberto Castioni, Andrea Salmaggi, Sofia Asioli, Marta Maschio, Giuseppe Minniti, Enrico Franceschi, Flavio Villani, Roberta Rudà, Eleonora Aronica, the Italian Multidisciplinary Group for Tumor Epilepsy, Paolo Vitali, Damiano Balestrini, Elisa D’Angelo, Lorenzo Bello, Marco Rossi, Marta Padovan, Anna Teresa Giallonardo, Carlo di Bonaventura, Francesco Toni, Angela La Neve, Simona Rizzato, Matteo Pugnaghi, Marco Vindigni, Carmelo Sturiale   +29 more
wiley   +1 more source

A myelin sheath protein forming its lattice. [PDF]

J Biol Chem, 2020
Tsuge H.
europepmc   +1 more source