Results 161 to 170 of about 331,716 (264)

A new diagnostic sampling method in pure neural leprosy: the scraping of the myelin sheath. [PDF]

An Bras Dermatol, 2021
Trave I, Cavalchini A, Barabino G, Parodi A.   +3 more
europepmc   +1 more source

Oligodendrocyte‐Targeted SGK1.1 Inhibition Alleviates White Matter Injury and Cognitive Impairment in Alzheimer's Disease via Modulation of HDAC2 Phosphorylation

CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.
We found an early Sgk1.1 mRNA upregulation within oligodendrocyte‐lineage cells of 5 × FAD mice, implicating SGK1.1 signaling as an early driver of myelin pathology. Mechanistically, SGK1.1 promotes HDAC2 phosphorylation at S422/S424, thereby impairing oligodendrocyte maturation.
Shiji Deng, Shenghan Gao, Chao Zhou, Zhen Lan, Huiya Li, Jiang Chen, Yuhao Xu, Jiashuo Li, Pinyi Liu, Siyuan Zhang, Xinyu Bao, Tingting Wang, Yun Xu, Xiaolei Zhu   +13 more
wiley   +1 more source

Developmental Deficiency of Oligodendrocytes and Myelination in the Central Nervous System of the Fetal Alcohol Syndrome Mouse Model

CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.
Impaired myelination was observed in the central nervous system (CNS) of the male fetal alcohol spectrum disorder (FASD) offspring associated with hyperactivity‐like behaviors, whereas the female FASD mice exhibit delayed myelin formation and normal behaviors, indicating a gender‐specific manner of FASD pathology.
Xiaoling Liang, Rulan Yi, Zhidan Ke, Yi Zhang, Liang Zhou   +4 more
wiley   +1 more source

Taurine and Metabolic Diseases: Molecular Mechanisms and Therapeutic Implications

Food Frontiers, Volume 7, Issue 5, September 2026.
The dietary sources of taurine, as well as its protective effects and mechanisms in metabolism‐related diseases and metabolic disorder–associated ocular and cerebral injuries. ABSTRACT Taurine (Tau) is a sulfur‐containing amino acid prevalent in animal tissues and primarily acquired through dietary sources.
Xiaojie Ma, Zhijian Rao, Lifang Zheng
wiley   +1 more source

Administration of Schwann Cell‐Like Cells Differentiated From Tonsil‐Derived Mesenchymal Stem Cells Promotes Peripheral Nerve Regeneration by Inducing Macrophage Polarization in a Chronic Constriction Injury Model

Muscle &Nerve, Volume 74, Issue 3, Page 728-739, September 2026.
TMSC‐SCs were mixed with fibrin adhesive and administered into the sciatic nerve of CCI rats, and nerve conduction studies and histopathological observations confirmed the regeneration of the peripheral nerve and gastrocnemius muscle. In addition, the expression of M1 and M2 macrophage markers was observed after the administration of TMSC‐SCs. ABSTRACT
Yu Hwa Nam, Ji‐Sup Kim, Yoonji Yum, Juhee Yoon, Youbeen Cho, Jaeseung Lim, Saeyoung Park, Sung‐Chul Jung   +7 more
wiley   +1 more source

Heparan sulfate and glycomimetics: Advances in synthesis and biological applications for post‐stroke neurorepair

Neuroprotection, Volume 4, Issue 3, Page 213-228, September 2026.
ECM, extracellular matrix; BDNF, brain‐derived neuroptrophic factor; FGF, fibroblast growth factor; VEGF, vascular endothelial growth factor. Abstract Heparan sulfate, a structurally diverse glycosaminoglycan that is abundant in the central nervous system (CNS), orchestrates essential processes fundamental to neural plasticity, neurorepair, and ...
Mozammel H. Bhuiyan, Madeleine J. Smith, Simon F. R. Hinkley, Andrew N. Clarkson   +3 more
wiley   +1 more source

Knockdown of G protein-coupled receptor-17 (GPR17) facilitates the regeneration and repair of myelin sheath post-periventricular leukomalacia (PVL). [PDF]

Bioengineered, 2021
He L, Yang H, Feng J, Wei T, Huang Y, Zhang X, Wang Z.   +6 more
europepmc   +1 more source

Association between breastfeeding and neurodevelopmental outcomes after late preterm birth

Pregnancy, Volume 2, Issue 5, September 2026.
Abstract Objective To test the hypothesis that breastfeeding is associated with improved neurodevelopmental outcomes among children delivered late preterm. Study design Secondary analysis of a prospective, follow‐up study of ≥6‐year‐old children enrolled in the Antenatal Late Preterm Steroid (ALPS) Trial, a multicenter study that assessed betamethasone
Anna Palatnik, Jessica A. de Voest, Alan T. N. Tita, Sean C. Blackwell, Monica Longo, T. Michael O'Shea, Dwight J. Rouse, Torri D. Metz, George R. Saade, Kara M. Rood, Kent D. Heyborne, John M. Thorp Jr, Geeta K. Swamy, Kelly S. Gibson, Yasser Y. El‐Sayed, Cynthia Gyamfi‐Bannerman, for the Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal‐Fetal Medicine Units Network   +16 more
wiley   +1 more source

Cdk7 Regulates Myelin Sheath Morphology and Lipid Homeostasis in Schwann Cells. [PDF]

Glia
Schumacher N, Pieltain A, Tocquin P, Thelen N, Lavergne A, Masar N, Terrasi R, Leloup R, Muccioli G, Gailly P, Arthur-Farraj P, Vandenbosch R, Franzen R.   +12 more
europepmc   +1 more source

The Neurovascular Niche: A Gathering Venue for Neuroinflammation and Remyelination in Multiple Sclerosis

Acta Physiologica, Volume 242, Issue 9, September 2026.
ABSTRACT In the central nervous system (CNS), the tissue microenvironment is continuously monitored and regulated to secure the unobstructed function of neurons and of their networks. This is a key function of the neurovascular niche (NVN), which is the interface between the cells of the nervous tissue and the cells and the content of blood vessels. It
Ilias Kazanis, Maria Elena Silva, Alerie G. de la Fuente, Fernando de Castro, Francisco J. Rivera   +4 more
wiley   +1 more source