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Anisotropic properties of the myelin sheath
Acta Histochemica, 1980Form birefringence curves were determined for fixed (and unfixed rat axons before and after lipid extraction. The total detected birefringence was assumed to be due to the macromolecular array of myelin sheath components (phospholipids, cholesterol, and proteins). Unfixed nerves displayed negative form birefringence.
B, de Campos Vidal +3 more
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Science Signaling, 2001
Schwann cells of the peripheral nervous system express periaxin, a cytosolic protein that contains a PDZ domain, a hallmark of adaptor proteins that assemble macromolecular signaling complexes. Mutations in the human periaxin gene cause the demyelinating neuropathy of Charcot-Marie-Tooth disease, and mice that lack functional periaxin ...
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Schwann cells of the peripheral nervous system express periaxin, a cytosolic protein that contains a PDZ domain, a hallmark of adaptor proteins that assemble macromolecular signaling complexes. Mutations in the human periaxin gene cause the demyelinating neuropathy of Charcot-Marie-Tooth disease, and mice that lack functional periaxin ...
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Evidence for Myelin Sheath Remodeling in the CNS Revealed by In Vivo Imaging [PDF]
Current Biology, 2018 The length of myelin sheaths affects conduction speed along axons and information propagation. It has recently become clear that myelin may be adaptively modified to modulate circuit function, implying that length remodeling of myelin sheaths should ...
Franziska Auer +2 more
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Glycoproteins of myelin sheaths
Journal of Molecular Neuroscience, 1997A growing number of glycoproteins have been identified and characterized in myelin and myelin-forming cells. In addition to the major P0 glycoprotein of compact PNS myelin and the myelin-associated glycoprotein (MAG) in the periaxonal membranes of myelin-forming oligodendrocytes and Schwann cells, the list now includes peripheral myelin protein-22 (PMP-
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Renewal of Phospholipids in the Myelin Sheath
1976It is apparent from previous work that the major brain phospholipids are synthesized in the endoplasmic reticulum and in vivo are transferred to ‘myelin’ in both developing and mature animals (l). Nevertheless, no transfer of phospholipids from ‘microsomes’ to ‘myelin’ has been demonstrated in vitro (2), after subcellular fractionation, as it has been ...
R M, Dawson, R M, Gould
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Spermidine: A constituent of the myelin sheath?
Neuroscience Letters, 1978Abstract Spermidine, an aliphatic polyamine present in high concentrations in the white matter, could act as a bivalent ligand stabilizing myelin lamellae. To seek an answer to the title's question, polyamines were extracted from the subcellular fractions of rat brain after intracerebral injection of [14C]putrescine, a precursor of spermidine ...
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Science's STKE, 2006
The myelin sheath electrically insulates axons and makes the conductance of neuronal impulses much more efficient. Chan et al . examined how the Schwann cells begin myelination of an axon. In neuronal cultures, a cell polarity protein, Par-3, localized to where the Schwann cell meets the axon and promoted the ...
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The myelin sheath electrically insulates axons and makes the conductance of neuronal impulses much more efficient. Chan et al . examined how the Schwann cells begin myelination of an axon. In neuronal cultures, a cell polarity protein, Par-3, localized to where the Schwann cell meets the axon and promoted the ...
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Arrangement of Cholesterol Molecules in the Myelin Sheath
Nature, 1962POLARIZED light studies1,2 have indicated that most or all lipid moieties of the myelin sheath are radially arranged. Finean3,4 correlated the X-ray diffraction patterns of fresh and lipid-solvent extracted myelin with known data about the form and size of lipid molecules and suggested that a phospholipid-cholesterol complex forms a part of myelin ...
J J, BUBIS, M, WOLMAN
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Galactolipids in the formation and function of the myelin sheath
Microscopy Research and Technique, 1998Among the most abundant components of myelin are the galactolipids galactocerebroside (GalC) and sulfatide. In spite of this abundance, the roles that these molecules play in the myelin sheath are not well understood. Until recently, our concept of GalC and sulfatide functions had been principally defined by immunological and chemical perturbation ...
J L, Dupree, K, Suzuki, B, Popko
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Morphology of Cryofixed Myelin Sheath
1998The myelin sheath is formed by concentrically apposed membrane pairs and shows a regularly layered pattern of alternating light lines and dense lines. Observation of cryofixed myelin demonstrated that the structures represent aqueous spaces. All lamellae of the myelin sheath show globular aggregates of particles and these particles are corresponding ...
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