Results 151 to 160 of about 331,716 (264)

Effect of 17β estradiol on hippocampus region of aging female rat brain: Ultrastructural study

American Journal of Experimental and Clinical Research, 2015
Estradiol has direct membrane-mediated effects on neurons and its effects are both neuroprotective and neurotrophic. This hormone modulates brain development and aging and affects neurochemical systems which are affected in age-related cognitive decline,
Rashmi Jha, Ranjeet Kumar, Priyanka Mishra, Abbas Ali Mahdi, Shivani Pandey, Najma Zaheer Baquer, Sudha Mahajan Cowsik   +6 more
doaj  

Axon and Myelin Sheath Segmentation in Electron Microscopy Images using Meta Learning. [PDF]

IEEE Appl Imag Pattern Recognit Workshop, 2022
Nguyen NP, Lopez S, Smith CL, Lever TE, Nichols NL, Bunyak F.   +5 more
europepmc   +1 more source

Elucidating the Molecular Mechanisms of Vitex negundo L. in Polycystic Ovary Syndrome via Metabolomics‐Driven Network Pharmacology

Biomedical Chromatography, Volume 40, Issue 9, September 2026.
ABSTRACT Polycystic ovary syndrome (PCOS) is a hormonal disorder marked by irregular menstrual cycles, elevated androgen levels, ovarian cysts, hirsutism, acne and other symptoms. While conventional medications such as Metformin and Spironolactone are commonly prescribed, they are often associated with undesirable side effects.
Nishmitha R. Poojary, Neeharika Narisepalli Venkatasai, Kannath U. Sanjay, Supraja M. Kodanch, Padmalatha S. Rai   +4 more
wiley   +1 more source

Decalcified and Decellularized Bone Conduits for Peripheral Nerve Regeneration: A Comparative In Vivo Study Using Rat Femur and Chicken Ulna Conduits

Brain and Behavior, Volume 16, Issue 9, September 2026.
ABSTRACT Purpose: Peripheral nerve injuries (PNIs) pose a major clinical challenge, especially when nerve gaps exceed 5 mm and spontaneous regeneration is inadequate. This study aimed to evaluate the regenerative potential of novel bone‐derived nerve guidance conduits (NGCs) fabricated from rat femoral diaphysis and chicken ulna as alternatives to ...
Zahra Sepehri, Ali Moradi, Nasser Mahdavi‐Shahri, Morteza Behnam Rassouli   +3 more
wiley   +1 more source

Broadening horizons: Pathogenesis and therapeutics of renal ciliopathies

Journal of Cell Communication and Signaling, Volume 20, Issue 3, September 2026.
This review elucidates the molecular mechanisms and aberrant signaling pathways in renal ciliopathies, links genetic heterogeneity to clinical phenotypes, and lays a theoretical basis for prenatal diagnosis and novel therapies. Abstract Renal ciliopathies encompass a spectrum of genetic disorders arising from structural or functional impairments of ...
Qiaowei Zhang, Shuwen Xue, Zhi Gao, Panlai Shi, Li Wang, Qi Feng, Xiangdong Kong, Xiaofan Zhu   +7 more
wiley   +1 more source

Myelin sheath and cyanobacterial thylakoids as concentric multilamellar structures with similar bioenergetic properties. [PDF]

Open Biol, 2021
Morelli AM, Chiantore M, Ravera S, Scholkmann F, Panfoli I.   +4 more
europepmc   +1 more source

Recent Advancements in Drug Delivery Across the Blood–Brain Barrier in Amyotrophic Lateral Sclerosis (ALS)

CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.
Progressive BBB/BSCB dysfunction is increasingly recognized as both a pathological feature and a therapeutic barrier in ALS. Novel delivery technologies and barrier‐restoration strategies may enhance CNS drug exposure, improve the efficacy of disease‐modifying therapies, and advance ALS treatment. ABSTRACT Background Amyotrophic lateral sclerosis (ALS)
Nitesh Sanghai, Kaitlyn Pierce, Nidhi Sharma, Sasha Leggett, Tara Chand Yadav, Pegah Masrori, Devi Atukorallaya, Senthilnathan Palaniyandi, Paul C. Marcogliese, Geoffrey K. Tranmer   +9 more
wiley   +1 more source

Regeneration of sensory nerve branches in extraction socket and surrounding alveolar bone in rat: immunohistochemical observation of the axon and myelin sheath changes. [PDF]

Odontology, 2023
Kakuta W, Matsunaga S, Otsu Y, Kitamura K, Abe S, Yajima Y, Sekine H.   +6 more
europepmc   +1 more source

Temporal Mapping of CSVD‐Related White Matter Lesions and Concurrent Neurovascular Dysfunction in Spontaneously Hypertensive Rats

CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.
Hypertension induces early neurovascular dysfunction of CSVD, with white matter lesion onset at 28 weeks of age and progression to behavior deficits at 36 weeks of age in spontaneously hypertensive rats. Pde10a/cAMP signaling dysregulation may be related to this process and represent a potential therapeutic target.
Jing Peng, Jingnian Ni, Fuyao Li, Ting Li, Mingqing Wei, Tianci Ge, Lulu Yao, Jing Shi, Jinzhou Tian   +8 more
wiley   +1 more source

FBXW7 regulates MYRF levels to control myelin capacity and homeostasis in the adult central nervous system

Nature Communications
Myelin, along with the oligodendrocytes (OLs) that produce it, is essential for proper central nervous system (CNS) function in vertebrates. Although the accurate targeting of myelin to axons and its maintenance are critical for CNS performance, the ...
Hannah Y. Collins, Ryan A. Doan, Jiaxing Li, Jason E. Early, Megan E. Madden, Tyrell Simkins, David A. Lyons, Kelly R. Monk, Ben Emery   +8 more
doaj   +1 more source