Results 151 to 160 of about 53,780 (245)
Nature CommunicationsMyelin, along with the oligodendrocytes (OLs) that produce it, is essential for proper central nervous system (CNS) function in vertebrates. Although the accurate targeting of myelin to axons and its maintenance are critical for CNS performance, the ...
Hannah Y. Collins +8 more
doaj +1 more source
Regeneration of sensory nerve branches in extraction socket and surrounding alveolar bone in rat: immunohistochemical observation of the axon and myelin sheath changes. [PDF]
Odontology, 2023 Kakuta W +6 more
europepmc +1 more source
Glia, Volume 74, Issue 5, May 2026.ZSWIM8, an E3 ubiquitin ligase that broadly targets IDR‐rich proteins, drives MiR‐7‐dependent AGO2 degradation and the turnover of many RBPs. Loss of ZSWIM8 leads to MiR‐7 accumulation in oligodendrocyte progenitor cells and myelination defects in the developing brain. ABSTRACT Proteostasis of proteins with intrinsically disordered regions (IDRs) is of
Jing Lei +13 more
wiley +1 more source
Nonvesicular lipid transfer drives myelin growth in the central nervous system
Nature CommunicationsOligodendrocytes extend numerous cellular processes that wrap multiple times around axons to generate lipid-rich myelin sheaths. Myelin biogenesis requires an enormously productive biosynthetic machinery for generating and delivering these large amounts ...
Jianping Wu +10 more
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A new diagnostic sampling method in pure neural leprosy: the scraping of the myelin sheath. [PDF]
An Bras Dermatol, 2021 Trave I +3 more
europepmc +1 more source
Inflammatory Mediators Both Directly and Indirectly Promote Microglial Proliferation
Glia, Volume 74, Issue 5, May 2026.– CSF2, IL3, and TNFɑ directly promote microglial proliferation. – Neuron‐secreted factors suppress microglial proliferation. – IL1 cytokines promote CSF2 release from astrocytes, which promotes microglial proliferation. ABSTRACT Microglia—the predominant immune cell of the central nervous system (CNS)—possess an astounding capacity for proliferation ...
Brady P. Hammond +4 more
wiley +1 more source
The Akt-mTOR Pathway Drives Myelin Sheath Growth by Regulating Cap-Dependent Translation. [PDF]
J Neurosci, 2021 Fedder-Semmes KN, Appel B.
europepmc +1 more source
Magnetic Resonance in Medicine, Volume 95, Issue 5, Page 2538-2553, May 2026.ABSTRACT Purpose To propose a signal acquisition and modeling framework for multi‐component tissue quantification that encompasses transmit field inhomogeneity, multi‐component relaxation and magnetization transfer (MT) effects. Theory and Methods By applying off‐resonance irradiation between excitation and acquisition within an RF‐spoiled gradient ...
Albert Jang +4 more
wiley +1 more source
Angewandte Chemie, Volume 138, Issue 18, 27 April 2026.Liquid chromatography tandem mass spectrometry and mass spectrometry imaging were used in combination with deuterium oxide administration to quantify and localise newly synthesised myelin lipids in the mouse brain. This methodology, used here to show sites of myelin repair, enables the measurement of dynamic lipid synthesis in living systems and ...
Catherine Zhang +7 more
wiley +2 more sources
Magnetic Resonance in Medicine, Volume 95, Issue 5, Page 2786-2796, May 2026.ABSTRACT Purpose Dorsal rhizotomy, or spinal dorsal nerve root lesioning, is a surgical procedure used to treat intractable nerve pain by selectively severing sensory afferent nerve roots. This study aimed to evaluate whether multiparametric MRI, including diffusion tensor imaging (DTI), quantitative magnetization transfer (qMT), chemical exchange ...
Feng Wang, John C. Gore, Li Min Chen
wiley +1 more source