Results 131 to 140 of about 331,716 (264)

Dysregulated TIE‐2 expression is associated with blood‐brain barrier leakiness and Alzheimer's disease‐related neuropathology

Brain Pathology, EarlyView.
Ince et al., have analysed TIE‐1 and ‐2 expression in human brain tissue, including microvessel‐enriched fractions (MVF) and covering a spectrum of AD‐associated pathology, and in CSF from independent cohorts spanning a clinical spectrum from normal cognition to AD.
Selvi Ince, Carol Van Hulle, Gwendlyn Kollmorgen, Clara Quijano‐Rubio, Carey Gleason, Barbara B. Bendlin, Ozioma Okonkwo, Sanjay Asthana, Kaj Blennow, Henrik Zetterberg, Sterling C. Johnson, Seth Love, J. Scott Miners   +12 more
wiley   +1 more source

Olfactory proteomics reveals the capacity of the HDAC1 inhibitor pyroxamide to halt the α‐synuclein preformed fibrils‐induced damage in nasal epithelial, microglial and dopaminergic neuronal cell lines

Brain Pathology, EarlyView.
Omics‐driven drug repositioning reveals pyroxamide as a neuroprotective HDAC1 inhibitor in Parkinson's disease models. Abstract Parkinson's disease (PD) is the second most common neurodegenerative disorder mainly characterized by the degeneration of dopaminergic neurons originating in the substantia nigra (SN) pars compacta and projecting to other ...
Paz Cartas‐Cejudo, Marina De Miguel, Leire Extramiana, Mercedes Lachén‐Montes, Silvia Romero‐Murillo, Djordje Gveric, Joaquín Fernández‐Irigoyen, Enrique Santamaría   +7 more
wiley   +1 more source

Bioinformatics analysis of myelin-microbe interactions suggests multiple types of molecular mimicry in the pathogenesis of multiple sclerosis.

PLoS ONE
Multiple sclerosis (MS) is a devastating autoimmune disease that leads to the destruction of the myelin sheath in the human central nervous system (CNS).
Ali Bigdeli, Mostafa Ghaderi-Zefrehei, Bluma J Lesch, Mehrdad Behmanesh, S Shahriar Arab   +4 more
doaj   +1 more source

Deciphering the conformational dynamics of Myelin Oligodendrocyte glycoprotein in the myelin sheath

Journal of Biomolecular Structure and Dynamics
Myelin Oligodendrocyte Glycoprotein (MOG) is a transmembrane protein in the myelin sheath. It acts as an auto-antigen under certain unknown conditions causing demyelination, thus resulting in Myelin Oligodendrocyte Glycoprotein Antibody-associated Disease (MOGAD).
Y. K. Ananya, L. Ramya
openaire   +2 more sources

Academic Achievement Test for Anatomy of the Neck: Validity and Reliability Analysis

European Journal of Dental Education, EarlyView.
ABSTRACT Objective Anatomy education remains a fundamental component of medical and dental curricula, and mastering neck anatomy is particularly challenging due to its structural complexity and clinical relevance. Despite its importance, there is a limited number of validated instruments specifically designed to assess academic achievement in neck ...
Dilber Polat, Halil Yilmaz
wiley   +1 more source

Myelin sheath survival following axonal degeneration in doubly myelinated nerve fibers

, 1991
Axonal contact plays a critical role in initiating myelin formation by Schwann cells. However, recent studies of “double myelination” have indicated that myelin maintenance continues in Schwann cells completely displaced from physical contact with the ...
JW Heath, GJ Kidd
core   +1 more source

Close relationship between β2‐microglobulin and type 2 diabetes‐associated peripheral neuropathy

Journal of Diabetes Investigation, EarlyView.
ABSTRACT Aims/Introduction This study aimed to elucidate the correlation between β2‐microglobulin (β2‐MG) and peripheral neuropathy in type 2 diabetes mellitus (T2DM). Materials and Methods Diabetic peripheral neuropathy (DPN) was defined on the nerve conduction study (NCS).
Jingfang Shao, Jinpeng Xu, Lili Zhou, Panruo Jiang   +3 more
wiley   +1 more source

Neuroanatomy education through the years: Revisiting the teaching slides used by Sir Wilfrid Edward Le Gros Clark

Journal of Anatomy, EarlyView.
This paper examines the life and legacy of British anatomist Sir Wilfrid Le Gros Clark through his neuroanatomical teaching collection at the University of Oxford. The authors catalogued 103 specimens and analyzed selected slides—including cases of multiple sclerosis, amyotrophic lateral sclerosis, tabes dorsalis, syringomyelia, and the pineal gland's ...
Shiva A. Nischal, Kush M. Kale, Katherine Tourigny, Mohammed Abuelem, Gretchen Greene, Rachel Walsh, Zoltán Molnár   +6 more
wiley   +1 more source

Understanding Exosomes in Hair Regeneration

Periodontology 2000, EarlyView.
Abstract Background Alopecia is a prevalent condition correlated with significant psychosocial challenges, while contemporary treatments exhibit variable efficacy, require extended use, and may cause adverse effects. This review aimed to comprehensively assess exosome‐mediated interventions as a novel cell‐free regenerative approach for hair ...
Paras Ahmad, Catherine Davies, Anton Sculean, Richard J. Miron   +3 more
wiley   +1 more source

Comparative Observation on Electroacupuncture and Manual Acupuncture in Rabbits with Facial Nerve Injury by Electron Microscope

针刺研究, 2017
Objective To observe the effect of manual acupuncture and electroacupuncture(EA)on ultrastructure of facial nerve Schwann cells,myelin sheath and mitochondria in facial nerve injury rabbits,so as to explore its mechanism underlying improving facial palsy.
LIU Li-an, WANG Zhao-qin, FU Jing-jing, DU Qian-qian, ZHANG Yi-yuan, JIAO Cui-cui, DONG Jing-jun   +6 more
doaj