Results 191 to 200 of about 232,901 (341)

Beyond nocardioform: Transcriptionally active microbes and host responses in equine mucoid placentitis

open access: yesEquine Veterinary Journal, EarlyView.
Abstract Background Nocardioform placentitis (NP) is an understudied form of equine placentitis historically attributed to nocardioform bacteria, yet it remains uncertain whether these organisms are the sole pathogens involved. Objectives To elucidate the pathophysiology of NP and the host–pathogen interaction. Study Design In vivo clinical multi‐omics
Machteld van Heule   +10 more
wiley   +1 more source

Nonvesicular lipid transfer drives myelin growth in the central nervous system

open access: yesNature Communications
Oligodendrocytes extend numerous cellular processes that wrap multiple times around axons to generate lipid-rich myelin sheaths. Myelin biogenesis requires an enormously productive biosynthetic machinery for generating and delivering these large amounts ...
Jianping Wu   +10 more
doaj   +1 more source

MyD88 Deficiency Protects Mice From Experimental Autoimmune Encephalomyelitis by Influencing Both Dendritic Cells and T Cells

open access: yesImmunology, EarlyView.
This study investigates the role of MyD88 in dendritic cells (DCs) and T cells during experimental autoimmune encephalomyelitis (EAE). We found that MyD88 is highly expressed in DCs and CD4+ T cells in people with multiple sclerosis, and its deficiency impairs DC maturation, reduces pro‐inflammatory cytokine production, weakens DC–T cell interactions ...
Wen Si   +4 more
wiley   +1 more source

MiR‐210‐3p is upregulated in diabetic peripheral neuropathy and may be involved in the progression of the disease by targeting brain‐derived neurotrophic factor

open access: yesJournal of Diabetes Investigation, EarlyView.
Elevated miR‐210‐3p expression was diagnostic for diabetic peripheral neuropathy (DPN) and served as an independent risk factor for DPN. miR‐210‐3p functioned by negatively regulating BDNF, and its inhibitor reversed hyperglycemia‐induced Schwann cell dysfunction, whereas BDNF knockdown eliminated this protective effect.
Yafei Zhao, Liu Wang, Dongcai Feng
wiley   +1 more source

Hair follicle stem cell fate supports distinct clinical endotypes in hidradenitis suppurativa

open access: yesJournal of the European Academy of Dermatology and Venereology, EarlyView.
Hair follicles (HFs) were extracted from skin biopsies. From these, original sequencing data were obtained and integrated with two independent studies to build a HF single‐cell transcriptomic atlas. It enabled delineating the fate of HF stem cells.
Audrey Onfroy   +17 more
wiley   +1 more source

Welfare and Physiological Consequences of Non‐Lethal Blood Sampling From the Caudal Vasculature of Atlantic Salmon (Salmo salar L.)

open access: yesJournal of Fish Diseases, EarlyView.
ABSTRACT The objective of this study was to evaluate welfare and health effects following single and repeated non‐lethal blood sampling from the caudal vasculature of Atlantic salmon. Two experiments were conducted at three different temperatures: a 6‐week freshwater experiment with fish weighing 50–100 g, undergoing up to four blood withdrawals, and a
Harriet Romstad   +9 more
wiley   +1 more source

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