Results 191 to 200 of about 201,896 (346)

Myelin sheaths: glycoproteins involved in their formation, maintenance and degeneration

, 2002
Richard H. Quarles
openalex   +2 more sources

A review of the putative antiseizure and antiepileptogenic mechanisms of action for soticlestat

Epilepsia, EarlyView.
Abstract Soticlestat (TAK‐935) is a potent and selective inhibitor of cholesterol 24‐hydroxylase (CYP46A1), an enzyme primarily expressed in the brain that catabolizes cholesterol to 24S‐hydroxycholesterol (24HC). In the ELEKTRA phase II clinical trial, soticlestat reduced seizure frequency in patients with developmental and epileptic encephalopathies,
Shinichi Kondo, Venkatesha Murthy, Mahnaz Asgharnejad, Arturo Benitez, Kosuke Nakashima, Nicole Hawkins, H. Steve White   +6 more
wiley   +1 more source

Individual neuronal subtypes control initial myelin sheath growth and stabilization. [PDF]

Neural Dev, 2020
Nelson HN, Treichel AJ, Eggum EN, Martell MR, Kaiser AJ, Trudel AG, Gronseth JR, Maas ST, Bergen S, Hines JH.   +9 more
europepmc   +1 more source

Evidence for Myelin Sheath Remodeling in the CNS Revealed by In Vivo Imaging

Current Biology, 2018
Franziska Auer, Stavros Vagionitis, Tim Czopka   +2 more
semanticscholar   +1 more source

The impact of early-life stress on the expression of genes associated with the formation of the myelin sheath of neurons in the prefrontal cortex of 15-day-old male mice

, 2020

openalex   +1 more source

Progressive sequential development of left and right‐sided idiopathic recurrent laryngeal neuropathy in a Standardbred racehorse

Equine Veterinary Education, EarlyView.
Summary A 4‐year‐old Standardbred racehorse presented to the hospital due to poor performance and abnormal respiratory noises. A high‐speed treadmill videoendoscopic examination including tracheal airway pressure measurements was performed. Grade C left recurrent neuropathy was diagnosed and a prosthetic laryngoplasty was performed.
H. M. B. Olsen, R. Sørby, E. Strand
wiley   +1 more source

A genome‐wide association study for recurrent laryngeal neuropathy in the Thoroughbred horse identifies a candidate gene that regulates myelin structure

Equine Veterinary Journal, EarlyView.
Abstract Background Equine recurrent laryngeal neuropathy (RLN) is an economically important upper respiratory tract (URT) disease with a genetic contribution to risk, but genetic variants independent of height have not been identified for Thoroughbreds.
Charlotte L. McGivney, Beatrice A. McGivney, Gabriella Farries, Katie F. Gough, Haige Han, Amy R. Holtby, David E. MacHugh, Lisa Michelle Katz, Emmeline W. Hill   +8 more
wiley   +1 more source

Motor pathway evaluation by transcranial magnetic stimulation in Swedish horses with acquired equine polyneuropathy

Equine Veterinary Journal, EarlyView.
Abstract Background Acquired equine polyneuropathy in Nordic horses (AEP) is the most prevalent equine polyneuropathy in Norway, Sweden, and Finland and is characterised by pelvic limb knuckling due to metatarsophalangeal extension dysfunction.
Anna May, Siv Hanche‐Olsen, Lutz S. Goehring, Kaspar Matiasek, Karin Hultin Jäderlund, Yury Zablotski, Gittan Gröndahl   +6 more
wiley   +1 more source

Protein succinylome analysis identifies citrate synthase as a central regulator of osteoclast metabolic activity

The FEBS Journal, EarlyView.
RANKL treatment induces expression of the aconitate decarboxylase (ACOD1) in differentiating osteoclasts, which increases succinate levels. The initially high expression of ACOD1 decreases towards the end of differentiation when the levels of the desuccinylase SIRT5 increase. Succinylation of citrate synthase (CS) was detected exclusively in stimulated
Dayoung Yu, Yue Gao, Marcin Luzarowski, Elisabeth Seebach, Thomas Heitkamp, Michael Börsch, Thomas Ruppert, Katharina F. Kubatzky   +7 more
wiley   +1 more source

Mind the GAPS: Glia associated with psychological stress

Journal of Neuroendocrinology, EarlyView.
Abstract Glial cells are an integral component of the nervous system, performing crucial functions that extend beyond structural support, including modulation of the immune system, tissue repair, and maintaining tissue homeostasis. Recent studies have highlighted the importance of glial cells as key mediators of stress responses across different organs.
Niklas Blank, Molly Weiner, Shaan Patel, Sarah Köhler, Christoph A. Thaiss   +4 more
wiley   +1 more source